Pulmonary Vasculature
Pulmonary Vasculature - Related Videos
09:58
A Method for Labeling Vasculature in Embryonic Mice
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Cited by 14 •
2011
This article describes a method for labeling embryonic skin and thymus blood vessels.
08:17
Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
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Cited by 8 •
2017
The following protocol describes the methodology for the acquisition and analysis of echocardiographic images used to obtain the Left Atrial Volume (LAV), Aorta (Ao) diameter, and Pulmonary Artery (PA) diameter in mice. This technique is a non-invasive, non-terminal procedure that allows assessment of the cardiopulmonary function.
08:55
In vivo Measurement of the Mouse Pulmonary Endothelial Surface Layer
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Cited by 17 •
2013
The endothelial glycocalyx/endothelial surface layer is ideally studied using intravital microscopy. Intravital microscopy is technically challenging in a moving organ such as the lung. We demonstrate how simultaneous brightfield and fluorescent microscopy may be used to estimate endothelial surface layer thickness in a freely-moving in vivo mouse lung.
09:52
Non-invasive Optical Imaging of the Lymphatic Vasculature of a Mouse
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Cited by 25 •
2013
Recently developed imaging techniques using near-infrared fluorescence (NIRF) may help elucidate the role the lymphatic system plays in cancer metastasis, immune response, wound repair, and other lymphatic-associated diseases.
13:32
Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
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Cited by 29 •
2014
Hypoxic pulmonary vasoconstriction (HPV) is an important physiological phenomenon by which at alveolar hypoxia lung perfusion is matched to ventilation. The major vascular segment contributing to HPV is the intra-acinar artery. Here, we describe our protocol for the analysis of HPV of murine pulmonary vessels with diameters of 20-100 μm.
FAQs
A low-pressure circulation allows blood to pass through the vessels surrounding the alveoli while supporting the exchange of oxygen and carbon dioxide. This design links vascular function directly to respiratory performance: disruption of normal pressure or flow can reduce the effectiveness of gas exchange and impair overall cardiopulmonary circulation.
Pulmonary arteries carry blood away from the right ventricle toward the lung capillaries, while pulmonary veins return oxygenated blood to the left atrium. Their coordinated direction of flow connects the heart’s right and left sides through the lungs, allowing the vascular network to support both gas exchange and effective circulation.
Vascular remodeling is an important clinical concept because structural changes in pulmonary vessels can alter how blood moves through the lungs. Its relevance becomes especially clear when evaluating pulmonary hypertension and other vascular disorders, where changes in circulation may require imaging, oxygenation studies, or hemodynamic measurements for assessment.
These conditions involve different clinical problems that can affect pulmonary vascular function and cardiopulmonary circulation. Pulmonary hypertension, pulmonary embolism, and congenital heart disease are therefore key contexts for studying this network. Evaluating the vessels in relation to each condition helps clinicians identify disease, understand its circulatory effects, and guide treatment.
Clinical assessment can include imaging, oxygenation studies, and hemodynamic measurements. Together, these approaches provide complementary information about the pulmonary vessels, blood oxygenation, and circulatory pressures or flow. Using more than one type of assessment can help identify disease and support decisions about treatment and further evaluation.
Imaging is one method used to examine the pulmonary vasculature in a clinical setting. Within the broader assessment process, it can help identify abnormalities associated with conditions such as pulmonary embolism, pulmonary hypertension, or congenital heart disease. Its findings can be considered alongside oxygenation and hemodynamic measurements when evaluating disease.
Oxygenation studies connect vascular assessment with the functional result of pulmonary circulation: movement of oxygen into the blood and carbon dioxide out of it. They can help clinicians evaluate whether circulation through the lung vessels is supporting effective gas exchange, making them useful alongside imaging and hemodynamic measurements.
Hemodynamic measurements provide information about the circulatory conditions within the cardiopulmonary system. In the pulmonary vasculature, this information is particularly relevant to understanding disorders such as pulmonary hypertension and other abnormalities affecting blood flow. Combined with imaging and oxygenation studies, the measurements help identify disease and guide treatment.