Bronchial Neovascularization
Bronchial Neovascularization - Related Videos
10:52
An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse
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Cited by 75 •
2014
Neovascularization (NV) of the cornea can complicate multiple visual pathologies. Utilizing a controlled, alkali-burn injury model, a quantifiable level of corneal NV can be produced for mechanistic study of corneal NV and evaluation of potential therapies for neovascular disorders.
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Cited by 4 •
2010
Bronchial thermoplasty is a non-drug procedure for severe persistent asthma that delivers thermal energy to the airway wall in a precisely controlled manner to reduce excessive airway smooth muscle. Reducing airway smooth muscle decreases the ability of the airways to constrict, thereby reducing the frequency of asthma attacks.
07:08
A Mouse Model for Laser-induced Choroidal Neovascularization
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Cited by 87 •
2015
Here, we present the mouse laser-induced choroidal neovascularization (CNV) protocol, an experimental model that re-creates the vascular hallmarks of neovascular age-related macular degeneration (AMD). Once mastered, it can reliably and effectively induce CNV as a model system to test various experimental measures.
14:32
Primary Human Bronchial Epithelial Cells Grown from Explants
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Cited by 19 •
2010
Here we describe a detailed method for growing primary human bronchial epithelial cells from explants of human bronchial airway tissue including differentiated growth on an air-liquid interface. This method provides an abundant source of primary cells for investigating the role of the airway epithelium in human lung health and disease.
09:56
In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
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Cited by 7 •
2018
Here, we present the usefulness of longitudinal in vivo imaging in the follow-up of morphological changes of laser-induced choroidal neovascularization in mice.
FAQs
Chronic inflammation, infection, and low oxygen levels can increase signals such as vascular endothelial growth factor. These signals stimulate endothelial cells, the cells lining blood vessels, to proliferate and migrate. The cells then organize into new vascular structures, allowing the bronchial circulation to remodel in response to persistent airway stress.
Excessive vascular growth may produce enlarged, fragile vessels rather than stable, well-adapted channels. Their connections with bronchial or systemic circulation can increase blood flow and vulnerability within diseased airways. If these abnormal vessels rupture, bleeding into the airways may occur, making vascular remodeling clinically important in patients with hemoptysis.
Asthma, chronic obstructive pulmonary disease, and bronchiectasis are important medical contexts for studying this remodeling. In each setting, ongoing airway inflammation or tissue injury can provide conditions that promote angiogenic signaling. The resulting vascular changes may contribute to airway structural alterations, influence inflammation, and increase concern about bleeding.
The remodeled vascular network can influence how diseased airway tissue responds to persistent injury. Increased vascular growth may support tissue repair processes, but excessive remodeling can also accompany continuing inflammation and worsen airway changes. This dual relationship helps explain why vascular responses are studied not only as a complication, but also as part of pulmonary disease biology.
Imaging can help evaluate vascular changes associated with pulmonary disorders and support clinical risk assessment. Its relevance is greatest when clinicians need to consider abnormal or enlarged vessels in the setting of airway disease or bleeding. Imaging findings can contribute to decisions about whether a vascular intervention, such as bronchial artery embolization, should be considered.
Bronchial artery embolization is relevant when abnormal bronchial vascularity contributes to clinically significant bleeding, particularly hemoptysis. The procedure is used as a treatment approach to address the involved arterial supply. In the broader management of pulmonary disease, understanding the vascular remodeling pattern helps connect the mechanism of bleeding with an appropriate interventional strategy.