Dean A. Lee Center for Childhood Cancer and Blood Disease Nationwide Children's Hospital Biography Publications Institution JoVE Articles Dean A. Lee has not added a biography. If you are Dean A. Lee and would like to personalize this page please email our Author Liaison for assistance. Publications Aggressive Natural Killer-cell Leukemia mutational Landscape and Drug Profiling Highlight JAK-STAT Signaling As Therapeutic Target Nature Communications. Apr, 2018 | Pubmed ID: 29674644 Inhibiting TGF-beta Signaling Preserves the Function of Highly Activated, in Vitro Expanded Natural Killer Cells in AML and Colon Cancer Models PloS One. 2018 | Pubmed ID: 29342200 Ex Vivo-expanded NK Cells from Blood and Ascites of Ovarian Cancer Patients Are Cytotoxic Against Autologous Primary Ovarian Cancer Cells Cancer Immunology, Immunotherapy : CII. Apr, 2018 | Pubmed ID: 29299659 Ex Vivo-expanded Natural Killer Cells Derived From Long-term Cryopreserved Cord Blood Are Cytotoxic Against Primary Breast Cancer Cells Journal of Immunotherapy (Hagerstown, Md. : 1997). Feb/Mar, 2018 | Pubmed ID: 29189387 Venous Thromboembolism in Pediatric Hematopoietic Cell Transplant: A Multicenter Cohort Study Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Feb, 2018 | Pubmed ID: 29128552 Radiotherapy Enhances Natural Killer Cell Cytotoxicity and Localization in Pre-clinical Canine Sarcomas and First-in-dog Clinical Trial Journal for Immunotherapy of Cancer. Dec, 2017 | Pubmed ID: 29254507 Phase 1 Clinical Trial Using MbIL21 Ex Vivo-expanded Donor-derived NK Cells After Haploidentical Transplantation Blood. 10, 2017 | Pubmed ID: 28835441 Ex Vivo Expanded Natural Killer Cells from Breast Cancer Patients and Healthy Donors Are Highly Cytotoxic Against Breast Cancer Cell Lines and Patient-derived Tumours Breast Cancer Research : BCR. Jul, 2017 | Pubmed ID: 28668076 IL-18/IL-15/IL-12 Synergy Induces Elevated and Prolonged IFN-γ Production by Ex Vivo Expanded NK Cells Which is Not Due to Enhanced STAT4 Activation Molecular Immunology. Aug, 2017 | Pubmed ID: 28644973 Interferon Gamma Induces Changes in Natural Killer (NK) Cell Ligand Expression and Alters NK Cell-Mediated Lysis of Pediatric Cancer Cell Lines Frontiers in Immunology. 2017 | Pubmed ID: 28428785 The Histone Deacetylase Inhibitor Valproic Acid Inhibits NKG2D Expression in Natural Killer Cells Through Suppression of STAT3 and HDAC3 Scientific Reports. Mar, 2017 | Pubmed ID: 28338101 Natural Killer Cells in Malignant Hematology: A Primer for the Non-immunologist Blood Reviews. Mar, 2017 | Pubmed ID: 27665023 NK Cell Therapy: Targeting Disease Relapse After Hematopoietic Stem Cell Transplantation Immunotherapy. Feb, 2012 | Pubmed ID: 22329587 Membrane-Bound IL-21 Promotes Sustained Ex Vivo Proliferation of Human Natural Killer Cells PloS One. 2012 | Pubmed ID: 22279576 Infusing CD19-Directed T Cells to Augment Disease Control in Patients Undergoing Autologous Hematopoietic Stem-Cell Transplantation for Advanced B-Lymphoid Malignancies Human Gene Therapy. Jan, 2012 | Pubmed ID: 22107246 Reprogramming CD19-specific T Cells with IL-21 Signaling Can Improve Adoptive Immunotherapy of B-lineage Malignancies Cancer Research. May, 2011 | Pubmed ID: 21558388 Acquisition, Preparation, and Functional Assessment of Human NK Cells for Adoptive Immunotherapy Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20686960 A High Throughput Microelectroporation Device to Introduce a Chimeric Antigen Receptor to Redirect the Specificity of Human T Cells Biomedical Microdevices. Oct, 2010 | Pubmed ID: 20574820 Combining CD19 Redirection and Alloanergization to Generate Tumor-specific Human T Cells for Allogeneic Cell Therapy of B-cell Malignancies Cancer Research. May, 2010 | Pubmed ID: 20424114 PiggyBac Transposon/transposase System to Generate CD19-specific T Cells for the Treatment of B-lineage Malignancies Human Gene Therapy. Apr, 2010 | Pubmed ID: 19905893 EBV+ Lymphoproliferative Disease Following Prolonged Chemotherapy for Refractory LCH Pediatric Blood & Cancer. Mar, 2008 | Pubmed ID: 17243127 C/EBPbeta Suppression by Interruption of CUGBP1 Resulting from a Complex Rearrangement of MLL Cancer Genetics and Cytogenetics. Sep, 2007 | Pubmed ID: 17854664 Rotavirus Vaccines The New England Journal of Medicine. Apr, 2006 | Pubmed ID: 16625014 Granulocytic Sarcoma Presenting As Pneumonia in a Child with T(8;21) Acute Myelogenous Leukemia: Diagnosis by Fluorescent in Situ Hybridization Journal of Pediatric Hematology/oncology. Jul, 2004 | Pubmed ID: 15218417 Tumor-specific Human CD4+ Regulatory T Cells and Their Ligands: Implications for Immunotherapy Immunity. Jan, 2004 | Pubmed ID: 14738769 Activated Peripheral T Lymphocytes Undergo Apoptosis when Cultured with Monocytes Activated by HLA Class II Ligation Cellular Immunology. Oct, 2003 | Pubmed ID: 14698144 Поколение нокаут-основной и Расширенный человеческого НК-клеток с помощью Cas9 Ribonucleoproteins Meisam Naeimi Kararoudi1, Hamid Dolatshad2, Prashant Trikha1, Syed-Rehan A. Hussain3, Ezgi Elmas1, Jennifer A. Foltz1, Jena E. Moseman1, Aarohi Thakkar1, Robin J. Nakkula1, Margaret Lamb1, Nitin Chakravarti1, K. John McLaughlin3, Dean A. Lee1 1Center for Childhood Cancer and Blood Disease, Nationwide Children's Hospital, 2Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, 3Center for Clinical and Translational Research, Nationwide Children's Hospital Research Institute JoVE 58237 Immunologia e infezioni Расширение, очистки и функциональной оценки периферической крови человека клетки NK Srinivas S. Somanchi1, Vladimir V. Senyukov1, Cecele J. Denman1, Dean A. Lee1 1Division of Pediatrics, MD Anderson Cancer Center - University of Texas JoVE 2540 Immunologia e infezioni
Поколение нокаут-основной и Расширенный человеческого НК-клеток с помощью Cas9 Ribonucleoproteins Meisam Naeimi Kararoudi1, Hamid Dolatshad2, Prashant Trikha1, Syed-Rehan A. Hussain3, Ezgi Elmas1, Jennifer A. Foltz1, Jena E. Moseman1, Aarohi Thakkar1, Robin J. Nakkula1, Margaret Lamb1, Nitin Chakravarti1, K. John McLaughlin3, Dean A. Lee1 1Center for Childhood Cancer and Blood Disease, Nationwide Children's Hospital, 2Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, 3Center for Clinical and Translational Research, Nationwide Children's Hospital Research Institute JoVE 58237 Immunologia e infezioni
Расширение, очистки и функциональной оценки периферической крови человека клетки NK Srinivas S. Somanchi1, Vladimir V. Senyukov1, Cecele J. Denman1, Dean A. Lee1 1Division of Pediatrics, MD Anderson Cancer Center - University of Texas JoVE 2540 Immunologia e infezioni