Guy Lippens UMR8576, CNRS Lille University Biography Publications Institution JoVE Articles Guy Lippens has not added a biography. If you are Guy Lippens and would like to personalize this page please email our Author Liaison for assistance. Publications The Study of Posttranslational Modifications of Tau Protein by Nuclear Magnetic Resonance Spectroscopy: Phosphorylation of Tau Protein by ERK2 Recombinant Kinase and Rat Brain Extract, and Acetylation by Recombinant Creb-Binding Protein Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 27975251 Molecular Dynamics Simulation of Tau Peptides for the Investigation of Conformational Changes Induced by Specific Phosphorylation Patterns Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 27975243 A β-Turn Motif in the Steroid Hormone Receptor's Ligand-Binding Domains Interacts with the Peptidyl-prolyl Isomerase (PPIase) Catalytic Site of the Immunophilin FKBP52 Biochemistry. Sep, 2016 | Pubmed ID: 27641460 NMR Meets Tau: Insights into Its Function and Pathology Biomolecules. Jun, 2016 | Pubmed ID: 27338491 Studying Intrinsically Disordered Proteins Under True In Vivo Conditions by Combined Cross-Polarization and Carbonyl-Detection NMR Spectroscopy Angewandte Chemie (International Ed. in English). Jun, 2016 | Pubmed ID: 27159340 Characterization of Neuronal Tau Protein As a Target of Extracellular Signal-regulated Kinase The Journal of Biological Chemistry. Apr, 2016 | Pubmed ID: 26858248 Tau Phosphorylation Regulates the Interaction Between BIN1's SH3 Domain and Tau's Proline-rich Domain Acta Neuropathologica Communications. Sep, 2015 | Pubmed ID: 26395440 Catalytic Site Inhibition of Insulin-degrading Enzyme by a Small Molecule Induces Glucose Intolerance in Mice Nature Communications. Sep, 2015 | Pubmed ID: 26394692 A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication The Journal of Biological Chemistry. Jul, 2015 | Pubmed ID: 26085105 The FK506-binding Protein FKBP52 in Vitro Induces Aggregation of Truncated Tau Forms with Prion-like Behavior FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2015 | Pubmed ID: 25888602 A Phosphorylation-Induced Turn Defines the Alzheimer's Disease AT8 Antibody Epitope on the Tau Protein Angewandte Chemie (International Ed. in English). Jun, 2015 | Pubmed ID: 25881502 Nuclear Magnetic Resonance Spectroscopy Characterization of Interaction of Tau with DNA and Its Regulation by Phosphorylation Biochemistry. Feb, 2015 | Pubmed ID: 25623359 Tau Monoclonal Antibody Generation Based on Humanized Yeast Models: Impact on Tau Oligomerization and Diagnostics The Journal of Biological Chemistry. Feb, 2015 | Pubmed ID: 25540200 H/D Exchange of a (15)N Labelled Tau Fragment As Measured by a Simple Relax-EXSY Experiment Journal of Magnetic Resonance (San Diego, Calif. : 1997). Oct, 2014 | Pubmed ID: 25462944 Phosphorylation in Intrinsically Disordered Regions Regulates the Activity of Neurogenin2 BMC Biochemistry. Nov, 2014 | Pubmed ID: 25374254 Mechanism of Tau-promoted Microtubule Assembly As Probed by NMR Spectroscopy Journal of the American Chemical Society. Sep, 2014 | Pubmed ID: 25162583 Nuclear Magnetic Resonance Analysis of the Acetylation Pattern of the Neuronal Tau Protein Biochemistry. May, 2014 | Pubmed ID: 24708343 Immunophilin FKBP52 Induces Tau-P301L Filamentous Assembly in Vitro and Modulates Its Activity in a Model of Tauopathy Proceedings of the National Academy of Sciences of the United States of America. Mar, 2014 | Pubmed ID: 24623856 A Functional Fragment of Tau Forms Fibers Without the Need for an Intermolecular Cysteine Bridge Biochemical and Biophysical Research Communications. Mar, 2014 | Pubmed ID: 24502945 Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice PloS One. 2013 | Pubmed ID: 24376810 Dissociation Kinetics of a Binary Complex in Solution by Protein Displacement Angewandte Chemie (International Ed. in English). Nov, 2013 | Pubmed ID: 24123878 A New Strategy for Sequential Assignment of Intrinsically Unstructured Proteins Based on 15N Single Isotope Labelling Journal of Magnetic Resonance (San Diego, Calif. : 1997). Nov, 2013 | Pubmed ID: 24018100 Unraveling a Phosphorylation Event in a Folded Protein by NMR Spectroscopy: Phosphorylation of the Pin1 WW Domain by PKA Journal of Biomolecular NMR. Apr, 2013 | Pubmed ID: 23456038 Tau Pathology Modulates Pin1 Post-translational Modifications and May Be Relevant As Biomarker Neurobiology of Aging. Mar, 2013 | Pubmed ID: 22926167 Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A The Journal of Biological Chemistry. Dec, 2012 | Pubmed ID: 23152499 Cell Signaling, Post-translational Protein Modifications and NMR Spectroscopy Journal of Biomolecular NMR. Nov, 2012 | Pubmed ID: 23011410 Post-translational Modification: Nature's Escape from Genetic Imprisonment and the Basis for Dynamic Information Encoding Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Nov-Dec, 2012 | Pubmed ID: 22899623 Towards Understanding the Phosphorylation Code of Tau Biochemical Society Transactions. Aug, 2012 | Pubmed ID: 22817719 Differential Contribution of the Repeats to Heparin Binding of HBHA, a Major Adhesin of Mycobacterium Tuberculosis PloS One. 2012 | Pubmed ID: 22403657 Structural Activation of the Transcriptional Repressor EthR from Mycobacterium Tuberculosis by Single Amino Acid Change Mimicking Natural and Synthetic Ligands Nucleic Acids Research. Apr, 2012 | Pubmed ID: 22156370 Structural Characterization by Nuclear Magnetic Resonance of the Impact of Phosphorylation in the Proline-rich Region of the Disordered Tau Protein Proteins. Feb, 2012 | Pubmed ID: 22072628 Ranking High Affinity Ligands of Low Solubility by NMR Spectroscopy ACS Medicinal Chemistry Letters. Jun, 2011 | Pubmed ID: 24900335 Characterization of the AT180 Epitope of Phosphorylated Tau Protein by a Combined Nuclear Magnetic Resonance and Fluorescence Spectroscopy Approach Biochemical and Biophysical Research Communications. Sep, 2011 | Pubmed ID: 21871442 Glycerol and Glycerol Carbonate As Ultraviscous Solvents for Mixture Analysis by NMR Journal of Magnetic Resonance (San Diego, Calif. : 1997). Sep, 2011 | Pubmed ID: 21802324 Systematic Identification of Tubulin-interacting Fragments of the Microtubule-associated Protein Tau Leads to a Highly Efficient Promoter of Microtubule Assembly The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21757739 Molecular Implication of PP2A and Pin1 in the Alzheimer's Disease Specific Hyperphosphorylation of Tau PloS One. 2011 | Pubmed ID: 21731772 Molecular Basis for an Ancient Partnership Between Prolyl Isomerase Pin1 and Phosphatase Inhibitor-2 Biochemistry. Aug, 2011 | Pubmed ID: 21714498 Substrate Recognition by the POTRA Domains of TpsB Transporter FhaC Molecular Microbiology. Jul, 2011 | Pubmed ID: 21542859 Domain 3 of NS5A Protein from the Hepatitis C Virus Has Intrinsic Alpha-helical Propensity and is a Substrate of Cyclophilin A The Journal of Biological Chemistry. Jun, 2011 | Pubmed ID: 21489988 Comparative Analysis of Erk Phosphorylation Suggests a Mixed Strategy for Measuring Phospho-form Distributions Molecular Systems Biology. Apr, 2011 | Pubmed ID: 21487401 Mice Lacking Phosphatase PP2A Subunit PR61/B'delta (Ppp2r5d) Develop Spatially Restricted Tauopathy by Deregulation of CDK5 and GSK3beta Proceedings of the National Academy of Sciences of the United States of America. Apr, 2011 | Pubmed ID: 21482799 Oleuropein and Derivatives from Olives As Tau Aggregation Inhibitors Neurochemistry International. May, 2011 | Pubmed ID: 21333710 Identification of O-GlcNAc Sites Within Peptides of the Tau Protein and Their Impact on Phosphorylation Molecular BioSystems. May, 2011 | Pubmed ID: 21327254 Intermolecular Interaction Studies Using Small Volumes Magnetic Resonance in Chemistry : MRC. Jan, 2011 | Pubmed ID: 21162136 DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-trans Isomerisation in Domain II of NS5A PloS One. Oct, 2010 | Pubmed ID: 21060866 Spectroscopic Studies of GSK3{beta} Phosphorylation of the Neuronal Tau Protein and Its Interaction with the N-terminal Domain of Apolipoprotein E The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20679343 NMR Spectroscopy of the Neuronal Tau Protein: Normal Function and Implication in Alzheimer's Disease Biochemical Society Transactions. Aug, 2010 | Pubmed ID: 20658994 Microtubule and MAPs: Thermodynamics of Complex Formation by AUC, ITC, Fluorescence, and NMR Methods in Cell Biology. 2010 | Pubmed ID: 20466148 The Domain 2 of the HCV NS5A Protein is Intrinsically Unstructured Protein and Peptide Letters. Aug, 2010 | Pubmed ID: 20450484 Structural Basis for the Non-immunosuppressive Character of the Cyclosporin A Analogue Debio 025 Biochemistry. Jun, 2010 | Pubmed ID: 20423153 Fluorescent BODIPY-based Zn(II) Complex As a Molecular Probe for Selective Detection of Neurofibrillary Tangles in the Brains of Alzheimer's Disease Patients Journal of the American Chemical Society. May, 2009 | Pubmed ID: 19368380 Hepatitis C Virus NS5A Protein is a Substrate for the Peptidyl-prolyl Cis/trans Isomerase Activity of Cyclophilins A and B The Journal of Biological Chemistry. May, 2009 | Pubmed ID: 19297321 Selective Backbone Labelling of ILV Methyl Labelled Proteins Journal of Biomolecular NMR. Apr, 2009 | Pubmed ID: 19288066 Domain 3 of Non-structural Protein 5A from Hepatitis C Virus is Natively Unfolded Biochemical and Biophysical Research Communications. Apr, 2009 | Pubmed ID: 19249289 Alzheimer Disease Specific Phosphoepitopes of Tau Interfere with Assembly of Tubulin but Not Binding to Microtubules FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2009 | Pubmed ID: 19074508 Graphical Interpretation of Boolean Operators for Protein NMR Assignments Journal of Biomolecular NMR. Sep, 2008 | Pubmed ID: 18762868 The Talin Rod IBS2 Alpha-helix Interacts with the Beta3 Integrin Cytoplasmic Tail Membrane-proximal Helix by Establishing Charge Complementary Salt Bridges The Journal of Biological Chemistry. Aug, 2008 | Pubmed ID: 18577523 Sandwich-ELISE NMR: Reducing the Sample Volume of NMR Samples Journal of Magnetic Resonance (San Diego, Calif. : 1997). Jul, 2008 | Pubmed ID: 18455452 NMR Observation of Tau in Xenopus Oocytes Journal of Magnetic Resonance (San Diego, Calif. : 1997). Jun, 2008 | Pubmed ID: 18378475 Measurement of Amyloid Fibril Length Distributions by Inclusion of Rotational Motion in Solution NMR Diffusion Measurements Angewandte Chemie (International Ed. in English). 2008 | Pubmed ID: 18350531 Microinjection of Recombinant O-GlcNAc Transferase Potentiates Xenopus Oocytes M-phase Entry Biochemical and Biophysical Research Communications. May, 2008 | Pubmed ID: 18298951 Tau Aggregation in Alzheimer's Disease: What Role for Phosphorylation? Prion. Jan-Mar, 2007 | Pubmed ID: 19164903 Contribution of Rotational Diffusion to Pulsed Field Gradient Diffusion Measurements The Journal of Chemical Physics. Sep, 2007 | Pubmed ID: 17887855 Structural and Functional Characterization of the Interaction Between Cyclophilin B and a Heparin-derived Oligosaccharide The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17855358 NMR Investigation of the Interaction Between the Neuronal Protein Tau and the Microtubules Biochemistry. Mar, 2007 | Pubmed ID: 17311412 Structural Impact of Heparin Binding to Full-length Tau As Studied by NMR Spectroscopy Biochemistry. Oct, 2006 | Pubmed ID: 17029411 Selective Intracellular Accumulation of the Major Metabolite Issued from the Activation of the Prodrug Ethionamide in Mycobacteria The Journal of Antimicrobial Chemotherapy. Oct, 2006 | Pubmed ID: 16895935 New DEFT Sequences for the Acquisition of One-dimensional Carbon NMR Spectra of Small Unlabelled Molecules Magnetic Resonance in Chemistry : MRC. Oct, 2006 | Pubmed ID: 16883554 ELISE NMR: Experimental Liquid Sealing of NMR Samples Journal of Magnetic Resonance (San Diego, Calif. : 1997). Aug, 2006 | Pubmed ID: 16709462 Arabidopsis PASTICCINO2 is an Antiphosphatase Involved in Regulation of Cyclin-dependent Kinase A The Plant Cell. Jun, 2006 | Pubmed ID: 16698944 Pin1 Allows for Differential Tau Dephosphorylation in Neuronal Cells Molecular and Cellular Neurosciences. May-Jun, 2006 | Pubmed ID: 16697218 NMR Analysis of a Tau Phosphorylation Pattern Journal of the American Chemical Society. Mar, 2006 | Pubmed ID: 16536530 Studying the Natively Unfolded Neuronal Tau Protein by Solution NMR Spectroscopy Protein and Peptide Letters. 2006 | Pubmed ID: 16515451 Regions of Tau Implicated in the Paired Helical Fragment Core As Defined by NMR Chembiochem : a European Journal of Chemical Biology. Oct, 2005 | Pubmed ID: 16196016 Control of Protein-protein Interactions: Structure-based Discovery of Low Molecular Weight Inhibitors of the Interactions Between Pin1 WW Domain and Phosphopeptides Journal of Medicinal Chemistry. Jul, 2005 | Pubmed ID: 16033261 High-resolution Magic Angle Spinning NMR of the Neuronal Tau Protein Integrated in Alzheimer's-like Paired Helical Fragments Journal of the American Chemical Society. Jul, 2005 | Pubmed ID: 16028903 Regulation of Pin1 Peptidyl-prolyl Cis/trans Isomerase Activity by Its WW Binding Module on a Multi-phosphorylated Peptide of Tau Protein FEBS Letters. Aug, 2005 | Pubmed ID: 16024016 Monitoring of the Ethionamide Pro-drug Activation in Mycobacteria by (1)H High Resolution Magic Angle Spinning NMR Biochemical and Biophysical Research Communications. Jun, 2005 | Pubmed ID: 15850780 Development of a High-resolution Magic-angle Spinning Nuclear Magnetic Resonance Identity Assay of the Capsular Polysaccharide from Haemophilus Influenzae Type B Present in Cetavlon Precipitate Analytical Biochemistry. Mar, 2005 | Pubmed ID: 15707931 Practical Aspects of Shimming a High Resolution Magic Angle Spinning Probe Journal of Magnetic Resonance (San Diego, Calif. : 1997). Mar, 2005 | Pubmed ID: 15705516 Accepting Its Random Coil Nature Allows a Partial NMR Assignment of the Neuronal Tau Protein Chembiochem : a European Journal of Chemical Biology. Dec, 2004 | Pubmed ID: 15532033 Characterization of the Arabidopsis Thaliana Arath;CDC25 Dual-specificity Tyrosine Phosphatase Biochemical and Biophysical Research Communications. Sep, 2004 | Pubmed ID: 15336525 A Small CDC25 Dual-specificity Tyrosine-phosphatase Isoform in Arabidopsis Thaliana Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004 | Pubmed ID: 15329414 Structural Analysis of Escherichia Coli OpgG, a Protein Required for the Biosynthesis of Osmoregulated Periplasmic Glucans Journal of Molecular Biology. Sep, 2004 | Pubmed ID: 15313617 The Peptidyl Prolyl Cis/trans-isomerase Pin1 Recognizes the Phospho-Thr212-Pro213 Site on Tau Biochemistry. Feb, 2004 | Pubmed ID: 14967043 Proline-directed Random-coil Chemical Shift Values As a Tool for the NMR Assignment of the Tau Phosphorylation Sites Chembiochem : a European Journal of Chemical Biology. Jan, 2004 | Pubmed ID: 14695515 Cobatoxin 1 from Centruroides Noxius Scorpion Venom: Chemical Synthesis, Three-dimensional Structure in Solution, Pharmacology and Docking on K+ Channels The Biochemical Journal. Jan, 2004 | Pubmed ID: 14498829 Neurofibrillary Degeneration of the Alzheimer-type: an Alternate Pathway to Neuronal Apoptosis? Biochemical Pharmacology. Oct, 2003 | Pubmed ID: 14555242 Restricted Linear Least Square Treatment Processing of Heteronuclear Spectra of Biomolecules Using the ANAFOR Strategy Journal of Magnetic Resonance (San Diego, Calif. : 1997). Apr, 2003 | Pubmed ID: 12713967 HRMAS NMR Observation of Beta-sheet Secondary Structure on a Water Swollen Solid Support Journal of Peptide Science : an Official Publication of the European Peptide Society. Jan, 2003 | Pubmed ID: 12587882 Pin1: a Therapeutic Target in Alzheimer Neurodegeneration Journal of Molecular Neuroscience : MN. Dec, 2002 | Pubmed ID: 12540053 Fine-tuned Characterization at the Solid/solution Interface of Organotin Compounds Grafted Onto Cross-linked Polystyrene by Using High-resolution MAS NMR Spectroscopy Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2002 | Pubmed ID: 12203323 Resin Dynamics Contributes to the NMR Line Broadening of Organic Molecules Grafted Onto a Polystyrene Resin Journal of Magnetic Resonance (San Diego, Calif. : 1997). Jun, 2002 | Pubmed ID: 12165259 Assignment of the 1H, 13C and 15N Resonances and Secondary Structure of the Monomeric P13suc1 Protein of Saccharomyces Pombe Journal of Biomolecular NMR. Jun, 2002 | Pubmed ID: 12153042 Solution Structure of the Single-domain Prolyl Cis/trans Isomerase PIN1At from Arabidopsis Thaliana Journal of Molecular Biology. Jul, 2002 | Pubmed ID: 12079389 Osmoregulated Periplasmic Glucans of the Free-living Photosynthetic Bacterium Rhodobacter Sphaeroides European Journal of Biochemistry. May, 2002 | Pubmed ID: 12027884 Solution NMR Study of the Monomeric Form of P13suc1 Protein Sheds Light on the Hinge Region Determining the Affinity for a Phosphorylated Substrate The Journal of Biological Chemistry. Apr, 2002 | Pubmed ID: 11812792 Solid-phase Enolate Chemistry Investigated Using HR-MAS NMR Spectroscopy The Journal of Organic Chemistry. Jan, 2002 | Pubmed ID: 11798327 Спектроскопии ядерного магнитного резонанса для идентификации нескольких фосфорилирований искробезопасных неупорядоченных белков Clément Danis*1,2, Clément Despres*1, Luiza M. Bessa1, Idir Malki1, Hamida Merzougui1, Isabelle Huvent1, Haoling Qi1, Guy Lippens1, François-Xavier Cantrelle1, Robert Schneider1, Xavier Hanoulle1, Caroline Smet-Nocca1, Isabelle Landrieu1 1UMR8576, CNRS, Lille University, 2UMR-S1172, INSERM CNRS, Lille University Biochimica
Спектроскопии ядерного магнитного резонанса для идентификации нескольких фосфорилирований искробезопасных неупорядоченных белков Clément Danis*1,2, Clément Despres*1, Luiza M. Bessa1, Idir Malki1, Hamida Merzougui1, Isabelle Huvent1, Haoling Qi1, Guy Lippens1, François-Xavier Cantrelle1, Robert Schneider1, Xavier Hanoulle1, Caroline Smet-Nocca1, Isabelle Landrieu1 1UMR8576, CNRS, Lille University, 2UMR-S1172, INSERM CNRS, Lille University Biochimica