Gwenn A. Garden Department of Neurology University of Washington Biography Publications Institution JoVE Articles Gwenn A. Garden has not added a biography. If you are Gwenn A. Garden and would like to personalize this page please email our Author Liaison for assistance. Publications Emerging Roles of P53 in Glial Cell Function in Health and Disease Glia. Apr, 2012 | Pubmed ID: 22105777 Spinocerebellar Ataxia Type 7 Cerebellar Disease Requires the Coordinated Action of Mutant Ataxin-7 in Neurons and Glia, and Displays Non-cell-autonomous Bergmann Glia Degeneration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2011 | Pubmed ID: 22072678 Transcription Factor P53 Influences Microglial Activation Phenotype Glia. Oct, 2011 | Pubmed ID: 21598312 Presenilin 2 is the Predominant γ-secretase in Microglia and Modulates Cytokine Release PloS One. 2010 | Pubmed ID: 21206757 Autophagy Activation and Enhanced Mitophagy Characterize the Purkinje Cells of Pcd Mice Prior to Neuronal Death Molecular Brain. 2009 | Pubmed ID: 19640278 Host and Viral Factors Influencing the Pathogenesis of HIV-associated Neurocognitive Disorders Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Jun, 2009 | Pubmed ID: 19373562 Polyglutamine-expanded Androgen Receptor Truncation Fragments Activate a Bax-dependent Apoptotic Cascade Mediated by DP5/Hrk The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2009 | Pubmed ID: 19228953 Molecular Pathogenesis and Cellular Pathology of Spinocerebellar Ataxia Type 7 Neurodegeneration Cerebellum (London, England). 2008 | Pubmed ID: 18418675 The Glial Response to CNS HIV Infection Includes P53 Activation and Increased Expression of P53 Target Genes Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Dec, 2007 | Pubmed ID: 18040854 Activation of the Extrinsic Caspase Pathway in Cultured Cortical Neurons Requires P53-mediated Down-regulation of the X-linked Inhibitor of Apoptosis Protein to Induce Apoptosis Journal of Neurochemistry. Aug, 2007 | Pubmed ID: 17488272 Predictors of Carotid Atherosclerotic Plaque Progression As Measured by Noninvasive Magnetic Resonance Imaging Atherosclerosis. Oct, 2007 | Pubmed ID: 16978632 Microglia Biology in Health and Disease Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Jun, 2006 | Pubmed ID: 18040779 Potential Applications and Limitations of Proteomics in the Study of Neurological Disease Archives of Neurology. Dec, 2006 | Pubmed ID: 17172608 Bergmann Glia Expression of Polyglutamine-expanded Ataxin-7 Produces Neurodegeneration by Impairing Glutamate Transport Nature Neuroscience. Oct, 2006 | Pubmed ID: 16936724 Association Between Carotid Plaque Characteristics and Subsequent Ischemic Cerebrovascular Events: a Prospective Assessment with MRI--initial Results Stroke; a Journal of Cerebral Circulation. Mar, 2006 | Pubmed ID: 16469957 The Multiple Roles of P53 in the Pathogenesis of HIV Associated Dementia Biochemical and Biophysical Research Communications. Jun, 2005 | Pubmed ID: 15865935 HIV Associated Neurodegeneration Requires P53 in Neurons and Microglia FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2004 | Pubmed ID: 15155568 Acyclovir Responsive Brain Stem Disease After the Ramsay Hunt Syndrome Journal of the Neurological Sciences. Jan, 2004 | Pubmed ID: 14675618 P53-dependent Cell Death Signaling in Neurons Neurochemical Research. Jan, 2003 | Pubmed ID: 12587660 Microglia in Human Immunodeficiency Virus-associated Neurodegeneration Glia. Nov, 2002 | Pubmed ID: 12379911 Polyglutamine-expanded Ataxin-7 Promotes Non-cell-autonomous Purkinje Cell Degeneration and Displays Proteolytic Cleavage in Ataxic Transgenic Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2002 | Pubmed ID: 12077187 Caspase Cascades in Human Immunodeficiency Virus-associated Neurodegeneration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2002 | Pubmed ID: 12019321 A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia Stephan J. Guyenet1, Stephanie A. Furrer2, Vincent M. Damian1, Travis D. Baughan2, Albert R. La Spada*3, Gwenn A. Garden*2 1Department of Biochemistry, University of Washington, 2Department of Neurology, University of Washington, 3Division of Genetics, Departments of Pediatrics and Cellular and Molecular Medicine, and the Institute for Genomic Medicine, University of California, San Diego - Rady Children’s Hospital JoVE 1787 Neuroscienze
A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia Stephan J. Guyenet1, Stephanie A. Furrer2, Vincent M. Damian1, Travis D. Baughan2, Albert R. La Spada*3, Gwenn A. Garden*2 1Department of Biochemistry, University of Washington, 2Department of Neurology, University of Washington, 3Division of Genetics, Departments of Pediatrics and Cellular and Molecular Medicine, and the Institute for Genomic Medicine, University of California, San Diego - Rady Children’s Hospital JoVE 1787 Neuroscienze
