Kelly M. McNagny The Biomedical Research Centre University of British Columbia Biography Publications Institution JoVE Articles Kelly M. McNagny has not added a biography. If you are Kelly M. McNagny and would like to personalize this page please email our Author Liaison for assistance. Publications HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression IScience. Mar, 2019 | Pubmed ID: 30818224 Podocalyxin is Required for Maintaining Blood-brain Barrier Function During Acute Inflammation Proceedings of the National Academy of Sciences of the United States of America. Feb, 2019 | Pubmed ID: 30787191 The First Identified Heterozygous Nonsense Mutations in Podocalyxin Offer New Perspectives on the Biology of Podocytopathies Clinical Science (London, England : 1979). Feb, 2019 | Pubmed ID: 30737302 IL-22 Preserves Gut Epithelial Integrity and Promotes Disease Remission During Chronic Infection Journal of Immunology (Baltimore, Md. : 1950). Feb, 2019 | Pubmed ID: 30617224 Mast Cells Promote Small Bowel Cancer in a Tumor Stage-specific and Cytokine-dependent Manner Proceedings of the National Academy of Sciences of the United States of America. 02, 2018 | Pubmed ID: 29429965 The Sialidase (Kdnase) Contributes to Cell Wall Integrity and Virulence in Amphotericin B-Treated Mice Frontiers in Microbiology. Month, 2017 | Pubmed ID: 29403452 Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development Stem Cells (Dayton, Ohio). 12, 2017 | Pubmed ID: 28905451 Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury American Journal of Respiratory Cell and Molecular Biology. 12, 2017 | Pubmed ID: 28683207 Induces a Type IV Hypersensitivity Response in a Mouse Model of Airway Inflammation Physiological Reports. Apr, 2017 | Pubmed ID: 28364028 Protein Interaction Screening Identifies SH3RF1 As a New Regulator of FAT1 Protein Levels FEBS Letters. Feb, 2017 | Pubmed ID: 28129444 The Orphan Nuclear Receptor RORα and Group 3 Innate Lymphoid Cells Drive Fibrosis in a Mouse Model of Crohn's Disease Science Immunology. Sep, 2016 | Pubmed ID: 28783681 The Orphan Nuclear Receptor ROR Alpha and Group 3 Innate Lymphoid Cells Drive Fibrosis in a Mouse Model of Crohn's Disease Science Immunology. Sep, 2016 | Pubmed ID: 28670633 Chronic Trichuris Muris Infection Alters Hematopoiesis and Causes IFN-γ-expressing T-cell Accumulation in the Mouse Bone Marrow European Journal of Immunology. 11, 2016 | Pubmed ID: 27594558 CD34 Promotes Pathological Epi-Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy PloS One. Month, 2016 | Pubmed ID: 27352134 G9a Regulates Group 2 Innate Lymphoid Cell Development by Repressing the Group 3 Innate Lymphoid Cell Program The Journal of Experimental Medicine. 06, 2016 | Pubmed ID: 27298444 SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling Developmental Cell. Apr, 2016 | Pubmed ID: 27046831 DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis PloS One. Month, 2016 | Pubmed ID: 27031833 Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice PloS One. Month, 2016 | Pubmed ID: 26998906 The Cell Surface Mucin Podocalyxin Regulates Collective Breast Tumor Budding Breast Cancer Research : BCR. Jan, 2016 | Pubmed ID: 26796961 Morphometric Analysis of Inflammation in Bronchial Biopsies Following Exposure to Inhaled Diesel Exhaust and Allergen Challenge in Atopic Subjects Particle and Fibre Toxicology. Jan, 2016 | Pubmed ID: 26758251 Dendritic-cell Expression of Ship1 Regulates Th2 Immunity to Helminth Infection in Mice European Journal of Immunology. Jan, 2016 | Pubmed ID: 26518471 Modelling Kidney Disease with CRISPR-mutant Kidney Organoids Derived from Human Pluripotent Epiblast Spheroids Nature Communications. Oct, 2015 | Pubmed ID: 26493500 Early Infancy Microbial and Metabolic Alterations Affect Risk of Childhood Asthma Science Translational Medicine. Sep, 2015 | Pubmed ID: 26424567 Podocalyxin Enhances Breast Tumor Growth and Metastasis and is a Target for Monoclonal Antibody Therapy Breast Cancer Research : BCR. Mar, 2015 | Pubmed ID: 25887862 Lineage-specific Regulation of Allergic Airway Inflammation by the Lipid Phosphatase Src Homology 2 Domain-containing Inositol 5-phosphatase (SHIP-1) The Journal of Allergy and Clinical Immunology. Sep, 2015 | Pubmed ID: 25746967 Pulmonary CD103 Expression Regulates Airway Inflammation in Asthma American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2015 | Pubmed ID: 25681437 Mast Cells in Human Health and Disease Methods in Molecular Biology (Clifton, N.J.). Month, 2015 | Pubmed ID: 25388247 Perinatal Antibiotic-induced Shifts in Gut Microbiota Have Differential Effects on Inflammatory Lung Diseases The Journal of Allergy and Clinical Immunology. Jan, 2015 | Pubmed ID: 25145536 Podocalyxin Regulates Murine Lung Vascular Permeability by Altering Endothelial Cell Adhesion PloS One. Month, 2014 | Pubmed ID: 25303643 Perinatal Immunization With Vaccine-Grade Listeria Monocytogenes Provides Protection Against Murine Th2 Airway Inflammation Allergy, Asthma & Immunology Research. Jul, 2014 | Pubmed ID: 24991458 Group 2 Innate Lymphoid Cells Facilitate Sensitization to Local, but Not Systemic, TH2-inducing Allergen Exposures The Journal of Allergy and Clinical Immunology. Apr, 2014 | Pubmed ID: 24679471 Methyltransferase G9A Regulates T Cell Differentiation During Murine Intestinal Inflammation The Journal of Clinical Investigation. May, 2014 | Pubmed ID: 24667637 Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-mediated Allergic Lung Inflammation Immunity. Mar, 2014 | Pubmed ID: 24613091 Enu Mutagenesis Identifies a Novel Platelet Phenotype in a Loss-of-function Jak2 Allele PloS One. Month, 2013 | Pubmed ID: 24086539 SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens PLoS Pathogens. Month, 2013 | Pubmed ID: 23950714 Requirement for Core 2 O-glycans for Optimal Resistance to Helminth Infection PloS One. Month, 2013 | Pubmed ID: 23555902 A Familiar Stranger: CD34 Expression and Putative Functions in SVF Cells of Adipose Tissue World Journal of Stem Cells. Jan, 2013 | Pubmed ID: 23362435 Perinatal Antibiotic Treatment Affects Murine Microbiota, Immune Responses and Allergic Asthma Gut Microbes. Mar-Apr, 2013 | Pubmed ID: 23333861 IL-7Rα and L-selectin, but Not CD103 or CD34, Are Required for Murine Peanut-induced Anaphylaxis Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology. Aug, 2012 | Pubmed ID: 22935073 Early Life Antibiotic-driven Changes in Microbiota Enhance Susceptibility to Allergic Asthma EMBO Reports. May, 2012 | Pubmed ID: 22422004 The Anti-adhesive Mucin Podocalyxin May Help Initiate the Transperitoneal Metastasis of High Grade Serous Ovarian Carcinoma Clinical & Experimental Metastasis. Mar, 2012 | Pubmed ID: 22262060 Analysis of the Mobilities of Band 3 Populations Associated with Ankyrin Protein and Junctional Complexes in Intact Murine Erythrocytes The Journal of Biological Chemistry. Feb, 2012 | Pubmed ID: 22147703 Cytopenia Induction by 5-fluorouracil Identifies Thrombopoietic Mutants in Sensitized ENU Mutagenesis Screens Experimental Hematology. Jan, 2012 | Pubmed ID: 21924221 CD34 Promotes Satellite Cell Motility and Entry into Proliferation to Facilitate Efficient Skeletal Muscle Regeneration Stem Cells (Dayton, Ohio). Dec, 2011 | Pubmed ID: 21997891 Infiltrating Monocytes Trigger EAE Progression, but Do Not Contribute to the Resident Microglia Pool Nature Neuroscience. Sep, 2011 | Pubmed ID: 21804537 CD34 is Required for Dendritic Cell Trafficking and Pathology in Murine Hypersensitivity Pneumonitis American Journal of Respiratory and Critical Care Medicine. Sep, 2011 | Pubmed ID: 21642249 Opposing Roles for CD34 in B16 Melanoma Tumor Growth Alter Early Stage Vasculature and Late Stage Immune Cell Infiltration PloS One. Apr, 2011 | Pubmed ID: 21494591 A Novel ENU-generated Truncation Mutation Lacking the Spectrin-binding and C-terminal Regulatory Domains of Ank1 Models Severe Hemolytic Hereditary Spherocytosis Experimental Hematology. Mar, 2011 | Pubmed ID: 21193012 CD34 is Required for Infiltration of Eosinophils into the Colon and Pathology Associated with DSS-induced Ulcerative Colitis The American Journal of Pathology. Sep, 2010 | Pubmed ID: 20696776 Interleukin-11 Reduces TLR4-induced Colitis in TLR2-deficient Mice and Restores Intestinal STAT3 Signaling Gastroenterology. Oct, 2010 | Pubmed ID: 20600022 CD34 Mediates Intestinal Inflammation in Salmonella-infected Mice Cellular Microbiology. Nov, 2010 | Pubmed ID: 20497179 The Metalloprotease-disintegrin ADAM8 is Essential for the Development of Experimental Asthma American Journal of Respiratory and Critical Care Medicine. Jun, 2010 | Pubmed ID: 20194813 Loss of CD34 Leads to Exacerbated Autoimmune Arthritis Through Increased Vascular Permeability Journal of Immunology (Baltimore, Md. : 1950). Feb, 2010 | Pubmed ID: 20038636 Stem Cells, Inflammation and Allergy Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology. Dec, 2009 | Pubmed ID: 20066174 Prion Protein Expression and Release by Mast Cells After Activation The Journal of Infectious Diseases. Sep, 2009 | Pubmed ID: 19642931 SHIP1 is a Repressor of Mast Cell Hyperplasia, Cytokine Production, and Allergic Inflammation in Vivo Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009 | Pubmed ID: 19542434 Bone Marrow-derived Mast Cells Accumulate in the Central Nervous System During Inflammation but Are Dispensable for Experimental Autoimmune Encephalomyelitis Pathogenesis Journal of Immunology (Baltimore, Md. : 1950). May, 2009 | Pubmed ID: 19380799 Mast Cells in Tumor Growth: Angiogenesis, Tissue Remodelling and Immune-modulation Biochimica Et Biophysica Acta. Aug, 2009 | Pubmed ID: 19233249 Podocalyxin Selectively Marks Erythroid-committed Progenitors During Anemic Stress but is Dispensable for Efficient Recovery Experimental Hematology. Jan, 2009 | Pubmed ID: 19004540 Mast Cells Are an Essential Hematopoietic Component for Polyp Development Proceedings of the National Academy of Sciences of the United States of America. Dec, 2007 | Pubmed ID: 18077429 CD34 Facilitates the Development of Allergic Asthma Blood. Sep, 2007 | Pubmed ID: 17557898 The CD34-related Molecule Podocalyxin is a Potent Inducer of Microvillus Formation PloS One. Feb, 2007 | Pubmed ID: 17311105 Na+/H+ Exchanger Regulatory Factor-1 is a Hematopoietic Ligand for a Subset of the CD34 Family of Stem Cell Surface Proteins Stem Cells (Dayton, Ohio). May, 2006 | Pubmed ID: 16410385 Hematopoietic Stem Cells Do Not Engraft with Absolute Efficiencies Blood. Jan, 2006 | Pubmed ID: 16204316 Podocalyxin is a CD34-related Marker of Murine Hematopoietic Stem Cells and Embryonic Erythroid Cells Blood. Jun, 2005 | Pubmed ID: 15701716 CD34 and CD43 Inhibit Mast Cell Adhesion and Are Required for Optimal Mast Cell Reconstitution Immunity. Jan, 2005 | Pubmed ID: 15664158 Overexpression of the Anti-adhesin Podocalyxin is an Independent Predictor of Breast Cancer Progression Cancer Research. Aug, 2004 | Pubmed ID: 15289306 E26 Leukemia Virus Converts Primitive Erythroid Cells into Cycling Multilineage Progenitors Blood. Feb, 2003 | Pubmed ID: 12393697 CD34 is a Specific Marker of Mature Murine Mast Cells Experimental Hematology. Oct, 2002 | Pubmed ID: 12384153 Avian Models to Study the Transcriptional Control of Hematopoietic Lineage Commitment and to Identify Lineage-specific Genes Cells, Tissues, Organs. Month, 2002 | Pubmed ID: 12021491 Anuria, Omphalocele, and Perinatal Lethality in Mice Lacking the CD34-related Protein Podocalyxin The Journal of Experimental Medicine. Jul, 2001 | Pubmed ID: 11435469 Chronic Salmonella Infection Induced Intestinal Fibrosis Bernard C. Lo1, Samuel B. Shin1, Melina Messing1, Kelly M. McNagny1 1The Biomedical Research Centre, University of British Columbia JoVE 60068 Immunologia e infezioni
Chronic Salmonella Infection Induced Intestinal Fibrosis Bernard C. Lo1, Samuel B. Shin1, Melina Messing1, Kelly M. McNagny1 1The Biomedical Research Centre, University of British Columbia JoVE 60068 Immunologia e infezioni