Lynn W. Enquist Department of Molecular Biology Princeton University Biography Publications Institution JoVE Articles Lynn W. Enquist has not added a biography. If you are Lynn W. Enquist and would like to personalize this page please email our Author Liaison for assistance. Publications Introduction: A New Coronavirus Emerges, This Time Causing a Pandemic Annual Review of Virology. Apr, 2020 | Pubmed ID: 32315256 The Neuropathic Itch Caused by Pseudorabies Virus Pathogens (Basel, Switzerland). Mar, 2020 | Pubmed ID: 32244386 Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A Journal of Virology. Apr, 2020 | Pubmed ID: 32075931 A Kinesin-3 Recruitment Complex Facilitates Axonal Sorting of Enveloped Alpha Herpesvirus Capsids PLoS Pathogens. 01, 2020 | Pubmed ID: 31995633 The Round Trip Model for Severe Herpes Zoster Caused by Live Attenuated Varicella Vaccine Virus Journal of Medical Virology. Jan, 2020 | Pubmed ID: 31943220 Alphaherpesvirus Infection of Mice Primes PNS Neurons to an Inflammatory State Regulated by TLR2 and Type I IFN Signaling PLoS Pathogens. 11, 2019 | Pubmed ID: 31675371 Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity American Journal of Respiratory and Critical Care Medicine. Mar, 2019 | Pubmed ID: 30309268 Reductio Ad Intellectum Annual Review of Virology. 09, 2018 | Pubmed ID: 30265630 Virulent Pseudorabies Virus Infection Induces a Specific and Lethal Systemic Inflammatory Response in Mice Journal of Virology. 12, 2018 | Pubmed ID: 30258005 Characterization of the Neuroinvasive Profile of a Pseudorabies Virus Recombinant Expressing the MTurquoise2 Reporter in Single and Multiple Injection Experiments Journal of Neuroscience Methods. 10, 2018 | Pubmed ID: 30098326 Retrograde Axonal Transport of Rabies Virus is Unaffected by Interferon Treatment but Blocked by Emetine Locally in Axons PLoS Pathogens. 07, 2018 | Pubmed ID: 30028873 Latent Versus Productive Infection: the Alpha Herpesvirus Switch Future Virology. May, 2018 | Pubmed ID: 29967651 Functional Carboxy-Terminal Fluorescent Protein Fusion to Pseudorabies Virus Small Capsid Protein VP26 Journal of Virology. 01, 2018 | Pubmed ID: 29046447 Compartmented Neuronal Cultures Reveal Two Distinct Mechanisms for Alpha Herpesvirus Escape from Genome Silencing PLoS Pathogens. Oct, 2017 | Pubmed ID: 29073268 Gene Expression Profiling with Cre-Conditional Pseudorabies Virus Reveals a Subset of Midbrain Neurons That Participate in Reward Circuitry The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 04, 2017 | Pubmed ID: 28283558 Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses Journal of Virology. Jan, 2017 | Pubmed ID: 27795407 Nerve Guidance by a Decellularized Fibroblast Extracellular Matrix Matrix Biology : Journal of the International Society for Matrix Biology. 07, 2017 | Pubmed ID: 27641621 Dual-Color Herpesvirus Capsids Discriminate Inoculum from Progeny and Reveal Axonal Transport Dynamics Journal of Virology. Nov, 2016 | Pubmed ID: 27581973 Exocytosis of Alphaherpesvirus Virions, Light Particles, and Glycoproteins Uses Constitutive Secretory Mechanisms MBio. 06, 2016 | Pubmed ID: 27273828 HSV-1 ICP27 Targets the TBK1-activated STING Signalsome to Inhibit Virus-induced Type I IFN expression The EMBO Journal. 07, 2016 | Pubmed ID: 27234299 The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions Diabetes. 09, 2016 | Pubmed ID: 27207534 The Diffusive Way Out: Herpesviruses Remodel the Host Nucleus, Enabling Capsids to Access the Inner Nuclear Membrane Nucleus (Austin, Tex.). 2016 | Pubmed ID: 26889771 Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion MBio. Feb, 2016 | Pubmed ID: 26838720 3D Printed Nervous System on a Chip Lab on a Chip. Apr, 2016 | Pubmed ID: 26669842 Defensive Perimeter in the Central Nervous System: Predominance of Astrocytes and Astrogliosis During Recovery from Varicella-Zoster Virus Encephalitis Journal of Virology. 01, 2016 | Pubmed ID: 26491149 3D Printed Anatomical Nerve Regeneration Pathways Advanced Functional Materials. Oct, 2015 | Pubmed ID: 26924958 Structural Basis of Vesicle Formation at the Inner Nuclear Membrane Cell. Dec, 2015 | Pubmed ID: 26687357 Fluorescent Protein Approaches in Alpha Herpesvirus Research Viruses. Nov, 2015 | Pubmed ID: 26610544 Open LED Illuminator: A Simple and Inexpensive LED Illuminator for Fast Multicolor Particle Tracking in Neurons PloS One. 2015 | Pubmed ID: 26600461 The Big ASM Tent: How to Represent the Microbial Sciences? MBio. Oct, 2015 | Pubmed ID: 26463168 Remodeling Nuclear Architecture Allows Efficient Transport of Herpesvirus Capsids by Diffusion Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015 | Pubmed ID: 26438852 The Number of Alphaherpesvirus Particles Infecting Axons and the Axonal Protein Repertoire Determines the Outcome of Neuronal Infection MBio. Mar, 2015 | Pubmed ID: 25805728 Investigating the Biology of Alpha Herpesviruses with MS-based Proteomics Proteomics. Jun, 2015 | Pubmed ID: 25764121 Axonal Spread of Neuroinvasive Viral Infections Trends in Microbiology. May, 2015 | Pubmed ID: 25639651 The Neuroinvasive Profiles of H129 (herpes Simplex Virus Type 1) Recombinants with Putative Anterograde-only Transneuronal Spread Properties Brain Structure & Function. 2015 | Pubmed ID: 24585022 Cellular Mechanisms of Alpha Herpesvirus Egress: Live Cell Fluorescence Microscopy of Pseudorabies Virus Exocytosis PLoS Pathogens. Dec, 2014 | Pubmed ID: 25474634 Characterization of a Replication-incompetent Pseudorabies Virus Mutant Lacking the Sole Immediate Early Gene IE180 MBio. Nov, 2014 | Pubmed ID: 25389174 Nuclear Herpesvirus Capsid Motility is Not Dependent on F-actin MBio. Oct, 2014 | Pubmed ID: 25293761 Long-term Cre-mediated Retrograde Tagging of Neurons Using a Novel Recombinant Pseudorabies Virus Frontiers in Neuroanatomy. 2014 | Pubmed ID: 25232307 Transneuronal Circuit Analysis with Pseudorabies Viruses Current Protocols in Neuroscience. Jul, 2014 | Pubmed ID: 24984685 Evolution and Diversity in Human Herpes Simplex Virus Genomes Journal of Virology. Jan, 2014 | Pubmed ID: 24227835 In Vivo Imaging of Alphaherpesvirus Infection Reveals Synchronized Activity Dependent on Axonal Sorting of Viral Proteins Proceedings of the National Academy of Sciences of the United States of America. Sep, 2013 | Pubmed ID: 23980169 Fast GCaMPs for Improved Tracking of Neuronal Activity Nature Communications. Jul, 2013 | Pubmed ID: 23863808 Glycoproteins GE and GI Are Required for Efficient KIF1A-Dependent Anterograde Axonal Transport of Alphaherpesvirus Particles in Neurons Journal of Virology. Sep, 2013 | Pubmed ID: 23804637 Imaging the Transport Dynamics of Single Alphaherpesvirus Particles in Intact Peripheral Nervous System Explants from Infected Mice MBio. 2013 | Pubmed ID: 23736287 Virus Infections in the Nervous System Cell Host & Microbe. Apr, 2013 | Pubmed ID: 23601101 Role of Us9 Phosphorylation in Axonal Sorting and Anterograde Transport of Pseudorabies Virus PloS One. 2013 | Pubmed ID: 23527020 Directional Spread of Alphaherpesviruses in the Nervous System Viruses. Feb, 2013 | Pubmed ID: 23435239 Efficient Retrograde Transport of Pseudorabies Virus Within Neurons Requires Local Protein Synthesis in Axons Cell Host & Microbe. Jan, 2013 | Pubmed ID: 23332155 Kinesin-3 Mediates Axonal Sorting and Directional Transport of Alphaherpesvirus Particles in Neurons Cell Host & Microbe. Dec, 2012 | Pubmed ID: 23245325 Alphaherpesvirus Axon-to-cell Spread Involves Limited Virion Transmission Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23027939 Alphaherpesvirus Infection Disrupts Mitochondrial Transport in Neurons Cell Host & Microbe. May, 2012 | Pubmed ID: 22607803 A Dual Infection Pseudorabies Virus Conditional Reporter Approach to Identify Projections to Collateralized Neurons in Complex Neural Circuits PloS One. 2011 | Pubmed ID: 21698154 Herpes Simplex Virus 1 PUL34 Plays a Critical Role in Cell-to-cell Spread of Virus in Addition to Its Role in Virus Replication Journal of Virology. Jul, 2011 | Pubmed ID: 21561917 Subversion of the Actin Cytoskeleton During Viral Infection Nature Reviews. Microbiology. Jun, 2011 | Pubmed ID: 21522191 Microdissection of Neural Networks by Conditional Reporter Expression from a Brainbow Herpesvirus Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21292985 Herpesviruses Carrying a Brainbow Cassette Reveal Replication and Expression of Limited Numbers of Incoming Genomes Nature Communications. 2010 | Pubmed ID: 21266996 A Common Neuronal Response to Alphaherpesvirus Infection Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Sep, 2010 | Pubmed ID: 20401540 Calcium Imaging of Neuronal Circuits in Vivo Using a Circuit-tracing Pseudorabies Virus Cold Spring Harbor Protocols. Apr, 2010 | Pubmed ID: 20360364 Pseudorabies Virus Infection Alters Neuronal Activity and Connectivity in Vitro PLoS Pathogens. Oct, 2009 | Pubmed ID: 19876391 Fluorescence-based Monitoring of in Vivo Neural Activity Using a Circuit-tracing Pseudorabies Virus PloS One. 2009 | Pubmed ID: 19742327 Virion-incorporated Glycoprotein B Mediates Transneuronal Spread of Pseudorabies Virus Journal of Virology. Aug, 2009 | Pubmed ID: 19494011 Virology in the 21st Century Journal of Virology. Jun, 2009 | Pubmed ID: 19297504 Inputs to Serotonergic Neurons Revealed by Conditional Viral Transneuronal Tracing The Journal of Comparative Neurology. May, 2009 | Pubmed ID: 19274668 Herpesvirus Interactions with the Host Cytoskeleton Journal of Virology. Mar, 2009 | Pubmed ID: 18842724 Targeting of Pseudorabies Virus Structural Proteins to Axons Requires Association of the Viral Us9 Protein with Lipid Rafts PLoS Pathogens. May, 2008 | Pubmed ID: 18483549 Alpha-herpesvirus Infection Induces the Formation of Nuclear Actin Filaments PLoS Pathogens. Aug, 2006 | Pubmed ID: 16933992 Transcriptome Signature of Virulent and Attenuated Pseudorabies Virus-infected Rodent Brain Journal of Virology. Feb, 2006 | Pubmed ID: 16439534 UL54-null Pseudorabies Virus is Attenuated in Mice but Productively Infects Cells in Culture Journal of Virology. Jan, 2006 | Pubmed ID: 16378979 Herpes Simplex Virus Type 1 Glycoprotein E is Required for Axonal Localization of Capsid, Tegument, and Membrane Glycoproteins Journal of Virology. Nov, 2005 | Pubmed ID: 16227258 Complete, Annotated Sequence of the Pseudorabies Virus Genome Journal of Virology. Jan, 2004 | Pubmed ID: 14671123 Recent Advances in the Use of Neurotropic Viruses for Circuit Analysis Current Opinion in Neurobiology. Oct, 2003 | Pubmed ID: 14630225 Brainstem Substrates of Sympatho-motor Circuitry Identified Using Trans-synaptic Tracing with Pseudorabies Virus Recombinants The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2003 | Pubmed ID: 12805305 In Vivo Egress of an Alphaherpesvirus from Axons Journal of Virology. Aug, 2002 | Pubmed ID: 12134036 Physical Interaction Between Envelope Glycoproteins E and M of Pseudorabies Virus and the Major Tegument Protein UL49 Journal of Virology. Aug, 2002 | Pubmed ID: 12134026 A Tyrosine-based Motif in the Cytoplasmic Tail of Pseudorabies Virus Glycoprotein B is Important for Both Antibody-induced Internalization of Viral Glycoproteins and Efficient Cell-to-cell Spread Journal of Virology. Jul, 2002 | Pubmed ID: 12050399 Intravitreal Injection of the Attenuated Pseudorabies Virus PRV Bartha Results in Infection of the Hamster Suprachiasmatic Nucleus Only by Retrograde Transsynaptic Transport Via Autonomic Circuits The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2002 | Pubmed ID: 11923435 Construction of a Self-excisable Bacterial Artificial Chromosome Containing the Human Cytomegalovirus Genome and Mutagenesis of the Diploid TRL/IRL13 Gene Journal of Virology. Mar, 2002 | Pubmed ID: 11836410 Herpesviruses Use Bidirectional Fast-axonal Transport to Spread in Sensory Neurons Proceedings of the National Academy of Sciences of the United States of America. Mar, 2001 | Pubmed ID: 11248101 Pseudorabies Virus Expressing Enhanced Green Fluorescent Protein: A Tool for in Vitro Electrophysiological Analysis of Transsynaptically Labeled Neurons in Identified Central Nervous System Circuits Proceedings of the National Academy of Sciences of the United States of America. Aug, 2000 | Pubmed ID: 10922076 A Self-recombining Bacterial Artificial Chromosome and Its Application for Analysis of Herpesvirus Pathogenesis Proceedings of the National Academy of Sciences of the United States of America. Apr, 2000 | Pubmed ID: 10781094 Directional Transneuronal Infection by Pseudorabies Virus is Dependent on an Acidic Internalization Motif in the Us9 Cytoplasmic Tail Journal of Virology. May, 2000 | Pubmed ID: 10775591 Role of the Cytoplasmic Tail of Pseudorabies Virus Glycoprotein E in Virion Formation Journal of Virology. May, 2000 | Pubmed ID: 10756012 Circuit-specific Coinfection of Neurons in the Rat Central Nervous System with Two Pseudorabies Virus Recombinants Journal of Virology. Nov, 1999 | Pubmed ID: 10516061 Construction and Transposon Mutagenesis in Escherichia Coli of a Full-length Infectious Clone of Pseudorabies Virus, an Alphaherpesvirus Journal of Virology. Aug, 1999 | Pubmed ID: 10400733 Pseudorabies Virus-induced Leukocyte Trafficking into the Rat Central Nervous System Journal of Virology. Nov, 1998 | Pubmed ID: 9765465 Different Patterns of Neuronal Infection After Intracerebral Injection of Two Strains of Pseudorabies Virus Journal of Virology. May, 1998 | Pubmed ID: 9557737 Interconnected Parallel Circuits Between Rat Nucleus Accumbens and Thalamus Revealed by Retrograde Transynaptic Transport of Pseudorabies Virus The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 1997 | Pubmed ID: 9045740 Small Alphaherpesvirus Latency-Associated Promoters Drive Efficient and Long-Term Transgene Expression in the CNS Molecular Therapy. Methods & Clinical Development. | Pubmed ID: 32368565 نموذج تلقيح لوحة الماوس للقدم لدراسة الاستجابات العصبية المستحثة بالفيروسات Kathlyn Laval1, Carola J. Maturana2, Lynn W. Enquist1 1Department of Molecular Biology, Princeton University, 2Princeton Neuroscience Institute, Princeton University JoVE 61121 Immunologia e infezioni
نموذج تلقيح لوحة الماوس للقدم لدراسة الاستجابات العصبية المستحثة بالفيروسات Kathlyn Laval1, Carola J. Maturana2, Lynn W. Enquist1 1Department of Molecular Biology, Princeton University, 2Princeton Neuroscience Institute, Princeton University JoVE 61121 Immunologia e infezioni