Naoto Hirano Department of Immunology University of Toronto Biography Publications Institution JoVE Articles Naoto Hirano has not added a biography. If you are Naoto Hirano and would like to personalize this page please email our Author Liaison for assistance. Publications BET Bromodomain Inhibition Enhances T Cell Persistence and Function in Adoptive Immunotherapy Models The Journal of Clinical Investigation. Sep, 2016 | Pubmed ID: 27548527 Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors PloS One. 2016 | Pubmed ID: 27213277 CD4(+) and CD8(+) TCRβ Repertoires Possess Different Potentials to Generate Extraordinarily High-avidity T Cells Scientific Reports. Mar, 2016 | Pubmed ID: 27030642 CDR3β Sequence Motifs Regulate Autoreactivity of Human Invariant NKT Cell Receptors Journal of Autoimmunity. Apr, 2016 | Pubmed ID: 26748722 Adoptive T Cell Therapy Targeting CD1 and MR1 Frontiers in Immunology. 2015 | Pubmed ID: 26052329 Optimization of T-cell Reactivity by Exploiting TCR Chain Centricity for the Purpose of Safe and Effective Antitumor TCR Gene Therapy Cancer Immunology Research. Sep, 2015 | Pubmed ID: 25943533 Specific Roles of Each TCR Hemichain in Generating Functional Chain-centric TCR Journal of Immunology (Baltimore, Md. : 1950). Apr, 2015 | Pubmed ID: 25710913 Human Cell-based Artificial Antigen-presenting Cells for Cancer Immunotherapy Immunological Reviews. Jan, 2014 | Pubmed ID: 24329798 Ex Vivo Expansion of Human CD8 T Cells Using Autologous CD4 T Cell Help PloS One. 2012 | Pubmed ID: 22279573 IL-21 Can Supplement Suboptimal Lck-Independent MAPK Activation in a STAT-3-Dependent Manner in Human CD8+ T Cells Journal of Immunology (Baltimore, Md. : 1950). Feb, 2012 | Pubmed ID: 22238455 [The Cutting Edge of Antitumor Adoptive Cell Therapy] [Rinsho Ketsueki] The Japanese Journal of Clinical Hematology. Oct, 2011 | Pubmed ID: 21971251 Induction of HLA-DP4-restricted Anti-survivin Th1 and Th2 Responses Using an Artificial Antigen-presenting Cell Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2011 | Pubmed ID: 21705450 The Third Consensus Conference on the Treatment of Aplastic Anemia International Journal of Hematology. Jun, 2011 | Pubmed ID: 21617886 Establishment of Antitumor Memory in Humans Using in Vitro-educated CD8+ T Cells Science Translational Medicine. Apr, 2011 | Pubmed ID: 21525398 A Panel of Human Cell-based Artificial APC Enables the Expansion of Long-lived Antigen-specific CD4+ T Cells Restricted by Prevalent HLA-DR Alleles International Immunology. Nov, 2010 | Pubmed ID: 21059769 Juvenile Myelomonocytic Leukemia: Epidemiology, Etiopathogenesis, Diagnosis, and Management Considerations Paediatric Drugs. 2010 | Pubmed ID: 20034338 Dissociation of Its Opposing Immunologic Effects is Critical for the Optimization of Antitumor CD8+ T-cell Responses Induced by Interleukin 21 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2008 | Pubmed ID: 18829491 Clinical Impact of HLA-DR15, a Minor Population of Paroxysmal Nocturnal Haemoglobinuria-type Cells, and an Aplastic Anaemia-associated Autoantibody in Children with Acquired Aplastic Anaemia British Journal of Haematology. Jul, 2008 | Pubmed ID: 18537977 Long-lived Antitumor CD8+ Lymphocytes for Adoptive Therapy Generated Using an Artificial Antigen-presenting Cell Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2007 | Pubmed ID: 17363542 Volcanism in Response to Plate Flexure Science (New York, N.Y.). Sep, 2006 | Pubmed ID: 16873612 Identification of an Immunogenic CD8+ T-cell Epitope Derived from Gamma-globin, a Putative Tumor-associated Antigen for Juvenile Myelomonocytic Leukemia Blood. Oct, 2006 | Pubmed ID: 16778141 Efficient Presentation of Naturally Processed HLA Class I Peptides by Artificial Antigen-presenting Cells for the Generation of Effective Antitumor Responses Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2006 | Pubmed ID: 16707591 Engagement of CD83 Ligand Induces Prolonged Expansion of CD8+ T Cells and Preferential Enrichment for Antigen Specificity Blood. Feb, 2006 | Pubmed ID: 16239433 The Chemical Structure of the Hawaiian Mantle Plume Nature. Aug, 2005 | Pubmed ID: 16100780 Presence of Anti-kinectin and Anti-PMS1 Antibodies in Japanese Aplastic Anaemia Patients British Journal of Haematology. Jan, 2005 | Pubmed ID: 15638857 Autoantibodies Frequently Detected in Patients with Aplastic Anemia Blood. Dec, 2003 | Pubmed ID: 12947009 The Shared Tumor-associated Antigen Cytochrome P450 1B1 is Recognized by Specific Cytotoxic T Cells Blood. Nov, 2003 | Pubmed ID: 12869499 Human Primary and Memory Cytotoxic T Lymphocyte Responses Are Efficiently Induced by Means of CD40-activated B Cells As Antigen-presenting Cells: Potential for Clinical Application Blood. May, 2002 | Pubmed ID: 11964299 Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain Tingxi Guo1,2, Toshiki Ochi*2, Munehide Nakatsugawa*2, Yuki Kagoya2, Mark Anczurowski1,2, Chung-Hsi Wang1,2, Muhammed A. Rahman2, Kayoko Saso2, Marcus O. Butler1,2, Naoto Hirano1,2 1Department of Immunology, University of Toronto, 2Princess Margaret Cancer Centre, University Health Network JoVE 54697 Immunologia e infezioni
Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain Tingxi Guo1,2, Toshiki Ochi*2, Munehide Nakatsugawa*2, Yuki Kagoya2, Mark Anczurowski1,2, Chung-Hsi Wang1,2, Muhammed A. Rahman2, Kayoko Saso2, Marcus O. Butler1,2, Naoto Hirano1,2 1Department of Immunology, University of Toronto, 2Princess Margaret Cancer Centre, University Health Network JoVE 54697 Immunologia e infezioni