Rick Maizels Institute of Immunology and Infection Research University of Edinburgh Biography Publications Institution JoVE Articles Rick Maizels has not added a biography. If you are Rick Maizels and would like to personalize this page please email our Author Liaison for assistance. Publications Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues Following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection PLoS Pathogens. Mar, 2015 | Pubmed ID: 25816012 Suppression of OVA-alum Induced Allergy by Heligmosomoides Polygyrus Products is MyD88-, TRIF-, Regulatory T- and B Cell-independent, but is Associated with Reduced Innate Lymphoid Cell Activation Experimental Parasitology. Feb, 2015 | Pubmed ID: 25728231 Known Allergen Structures Predict Schistosoma Mansoni IgE-Binding Antigens in Human Infection Frontiers in Immunology. 2015 | Pubmed ID: 25691884 CCR7-dependent Trafficking of RORγ⁺ ILCs Creates a Unique Microenvironment Within Mucosal Draining Lymph Nodes Nature Communications. 2015 | Pubmed ID: 25575242 Exosomes Secreted by Nematode Parasites Transfer Small RNAs to Mammalian Cells and Modulate Innate Immunity Nature Communications. 2014 | Pubmed ID: 25421927 Chitinase-like Proteins Promote IL-17-mediated Neutrophilia in a Tradeoff Between Nematode Killing and Host Damage Nature Immunology. Dec, 2014 | Pubmed ID: 25326751 MHC-II: a Mutual Support System for ILCs and T Cells? Immunity. Aug, 2014 | Pubmed ID: 25148019 Commensal-pathogen Interactions in the Intestinal Tract: Lactobacilli Promote Infection With, and Are Promoted By, Helminth Parasites Gut Microbes. Jul, 2014 | Pubmed ID: 25144609 MyD88 Signaling Inhibits Protective Immunity to the Gastrointestinal Helminth Parasite Heligmosomoides Polygyrus Journal of Immunology (Baltimore, Md. : 1950). Sep, 2014 | Pubmed ID: 25114104 Immunology. How Helminths Go Viral Science (New York, N.Y.). Aug, 2014 | Pubmed ID: 25082688 Secreted Proteomes of Different Developmental Stages of the Gastrointestinal Nematode Nippostrongylus Brasiliensis Molecular & Cellular Proteomics : MCP. Oct, 2014 | Pubmed ID: 24994561 Inflammatory Bowel Disease Evolution, Medicine, and Public Health. Apr, 2014 | Pubmed ID: 24747119 Real-time PCR Detection of the HhaI Tandem DNA Repeat in Pre- and Post-patent Brugia Malayi Infections: a Study in Indonesian Transmigrants Parasites & Vectors. 2014 | Pubmed ID: 24685183 Vaccination Against Helminth Parasite Infections Expert Review of Vaccines. Apr, 2014 | Pubmed ID: 24606541 The Secreted Triose Phosphate Isomerase of Brugia Malayi is Required to Sustain Microfilaria Production in Vivo PLoS Pathogens. Feb, 2014 | Pubmed ID: 24586152 Innate and Adaptive Type 2 Immune Cell Responses in Genetically Controlled Resistance to Intestinal Helminth Infection Immunology and Cell Biology. May-Jun, 2014 | Pubmed ID: 24492801 IL-6 Controls Susceptibility to Helminth Infection by Impeding Th2 Responsiveness and Altering the Treg Phenotype in Vivo European Journal of Immunology. Jan, 2014 | Pubmed ID: 24185641 Helminths and Immunological Tolerance Transplantation. Jan, 2014 | Pubmed ID: 24025322 IL-4 Directly Signals Tissue-resident Macrophages to Proliferate Beyond Homeostatic Levels Controlled by CSF-1 The Journal of Experimental Medicine. Oct, 2013 | Pubmed ID: 24101381 Secretion of Protective Antigens by Tissue-stage Nematode Larvae Revealed by Proteomic Analysis and Vaccination-induced Sterile Immunity PLoS Pathogens. Aug, 2013 | Pubmed ID: 23966853 Into the Wild: Digging at Immunology's Evolutionary Roots Nature Immunology. Sep, 2013 | Pubmed ID: 23959175 Oesophagostomum Dentatum Extract Modulates T Cell-dependent Immune Responses to Bystander Antigens and Prevents the Development of Allergy in Mice PloS One. 2013 | Pubmed ID: 23844022 Gain of Function in the Immune System Caused by a Ryanodine Receptor 1 Mutation Journal of Cell Science. Aug, 2013 | Pubmed ID: 23704352 Toxocara Canis: Molecular Basis of Immune Recognition and Evasion Veterinary Parasitology. Apr, 2013 | Pubmed ID: 23351972 ICOS Controls Foxp3(+) Regulatory T-cell Expansion, Maintenance and IL-10 Production During Helminth Infection European Journal of Immunology. Mar, 2013 | Pubmed ID: 23319295 Immunomodulation by Helminth Parasites: Defining Mechanisms and Mediators International Journal for Parasitology. Mar, 2013 | Pubmed ID: 23291463 A Transcriptomic Analysis of Echinococcus Granulosus Larval Stages: Implications for Parasite Biology and Host Adaptation PLoS Neglected Tropical Diseases. 2012 | Pubmed ID: 23209850 モデルの腸内寄生虫寄生虫 Heligmosomoides Polygyrus への耐性。 Seminars in Immunopathology. Nov, 2012 | Pubmed ID: 23053394 Helminth Infections and Host Immune Regulation Clinical Microbiology Reviews. Oct, 2012 | Pubmed ID: 23034321 Antibodies and IL-3 Support Helminth-induced Basophil Expansion Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012 | Pubmed ID: 22930820 Type 2 Innate Immunity in Helminth Infection is Induced Redundantly and Acts Autonomously Following CD11c(+) Cell Depletion Infection and Immunity. Oct, 2012 | Pubmed ID: 22851746 Susceptibility and Immunity to Helminth Parasites Current Opinion in Immunology. Aug, 2012 | Pubmed ID: 22795966 Prevention of Birch Pollen-related Food Allergy by Mucosal Treatment with Multi-allergen-chimers in Mice PloS One. 2012 | Pubmed ID: 22768077 Cutting Edge: in the Absence of TGF-β Signaling in T Cells, Fewer CD103+ Regulatory T Cells Develop, but Exuberant IFN-γ Production Renders Mice More Susceptible to Helminth Infection Journal of Immunology (Baltimore, Md. : 1950). Aug, 2012 | Pubmed ID: 22753928 Suppression of Type 2 Immunity and Allergic Airway Inflammation by Secreted Products of the Helminth Heligmosomoides Polygyrus European Journal of Immunology. Oct, 2012 | Pubmed ID: 22706967 Regulatory T Cells in Human Lymphatic Filariasis: Stronger Functional Activity in Microfilaremics PLoS Neglected Tropical Diseases. 2012 | Pubmed ID: 22666510 Forum: Immunology: Allergy Challenged Nature. Apr, 2012 | Pubmed ID: 22538601 T Cells in Helminth Infection: the Regulators and the Regulated Trends in Immunology. Apr, 2012 | Pubmed ID: 22398370 Immune Modulation and Modulators in Heligmosomoides Polygyrus Infection Experimental Parasitology. Sep, 2012 | Pubmed ID: 21875581 Regulatory T Cells in Infection Advances in Immunology. 2011 | Pubmed ID: 22118407 Wild Immunology: Converging on the Real World Annals of the New York Academy of Sciences. Oct, 2011 | Pubmed ID: 22032399 Heligmosomoides Polygyrus Elicits a Dominant Nonprotective Antibody Response Directed Against Restricted Glycan and Peptide Epitopes Journal of Immunology (Baltimore, Md. : 1950). Nov, 2011 | Pubmed ID: 21964031 Addendum: Defeating Sepsis by Misleading MyD88 Nature Immunology. Aug, 2011 | Pubmed ID: 21772287 Proteomic Analysis of Secretory Products from the Model Gastrointestinal Nematode Heligmosomoides Polygyrus Reveals Dominance of Venom Allergen-like (VAL) Proteins Journal of Proteomics. Aug, 2011 | Pubmed ID: 21722761 Th2 Responses to Helminth Parasites Can Be Therapeutically Enhanced By, but Are Not Dependent Upon, GITR-GITR Ligand Costimulation in Vivo Journal of Immunology (Baltimore, Md. : 1950). Aug, 2011 | Pubmed ID: 21705620 Diversity and Dialogue in Immunity to Helminths Nature Reviews. Immunology. Jun, 2011 | Pubmed ID: 21610741 Analyzing Airway Inflammation with Chemical Biology: Dissection of Acidic Mammalian Chitinase Function with a Selective Drug-like Inhibitor Chemistry & Biology. May, 2011 | Pubmed ID: 21609838 Chronic Helminth Infection Promotes Immune Regulation in Vivo Through Dominance of CD11cloCD103- Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Jun, 2011 | Pubmed ID: 21576507 Schistosome Infection Intensity is Inversely Related to Auto-reactive Antibody Levels PloS One. 2011 | Pubmed ID: 21573157 Immunology. Eosinophils Forestall Obesity Science (New York, N.Y.). Apr, 2011 | Pubmed ID: 21474746 Defeating Sepsis by Misleading MyD88 Nature Immunology. Apr, 2011 | Pubmed ID: 21423223 Regulatory and Activated T Cells in Human Schistosoma Haematobium Infections PloS One. 2011 | Pubmed ID: 21347311 Heligmosomoides Polygyrus: One Species Still Trends in Parasitology. Mar, 2011 | Pubmed ID: 21159557 Helminth Secretions Induce De Novo T Cell Foxp3 Expression and Regulatory Function Through the TGF-β Pathway The Journal of Experimental Medicine. Oct, 2010 | Pubmed ID: 20876311 Developmental Regulation and Extracellular Release of a VSG Expression-site-associated Gene Product from Trypanosoma Brucei Bloodstream Forms Journal of Cell Science. Oct, 2010 | Pubmed ID: 20826456 CD11c Depletion Severely Disrupts Th2 Induction and Development in Vivo The Journal of Experimental Medicine. Sep, 2010 | Pubmed ID: 20819926 Helminth-induced CD19+CD23hi B Cells Modulate Experimental Allergic and Autoimmune Inflammation European Journal of Immunology. Jun, 2010 | Pubmed ID: 20306466 Regulatory T Cells in Human Geohelminth Infection Suppress Immune Responses to BCG and Plasmodium Falciparum European Journal of Immunology. Feb, 2010 | Pubmed ID: 20063313 Regulation of Pathogenesis and Immunity in Helminth Infections The Journal of Experimental Medicine. Sep, 2009 | Pubmed ID: 19770272 Dynamics of CD11c(+) Dendritic Cell Subsets in Lymph Nodes Draining the Site of Intestinal Nematode Infection Immunology Letters. Dec, 2009 | Pubmed ID: 19766674 A Family of Diverse Kunitz Inhibitors from Echinococcus Granulosus Potentially Involved in Host-parasite Cross-talk PloS One. 2009 | Pubmed ID: 19759914 C-type Lectins from the Nematode Parasites Heligmosomoides Polygyrus and Nippostrongylus Brasiliensis Parasitology International. Dec, 2009 | Pubmed ID: 19751847 Parasite Immunomodulation and Polymorphisms of the Immune System Journal of Biology. 2009 | Pubmed ID: 19664200 Helminth Immunoregulation: the Role of Parasite Secreted Proteins in Modulating Host Immunity Molecular and Biochemical Parasitology. Sep, 2009 | Pubmed ID: 19406170 Generating EST Libraries: Trans-spliced CDNAs Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19277559 How Common is Human Toxocariasis? Towards Standardizing Our Knowledge Trends in Parasitology. Apr, 2009 | Pubmed ID: 19269251 A Pivotal Role for CD40-mediated IL-6 Production by Dendritic Cells During IL-17 Induction in Vivo Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009 | Pubmed ID: 19234175 MIF Homologues from a Filarial Nematode Parasite Synergize with IL-4 to Induce Alternative Activation of Host Macrophages Journal of Leukocyte Biology. May, 2009 | Pubmed ID: 19179453 Early Recruitment of Natural CD4+ Foxp3+ Treg Cells by Infective Larvae Determines the Outcome of Filarial Infection European Journal of Immunology. Jan, 2009 | Pubmed ID: 19089814 Expansion of Foxp3+ Regulatory T Cells in Mice Infected with the Filarial Parasite Brugia Malayi Journal of Immunology (Baltimore, Md. : 1950). Nov, 2008 | Pubmed ID: 18941236 T-cell Regulation in Helminth Parasite Infections: Implications for Inflammatory Diseases Chemical Immunology and Allergy. 2008 | Pubmed ID: 18802342 Four Abundant Novel Transcript Genes from Toxocara Canis with Unrelated Coding Sequences Share Untranslated Region Tracts Implicated in the Control of Gene Expression Molecular and Biochemical Parasitology. Nov, 2008 | Pubmed ID: 18703093 Age-related and Infection Intensity-related Shifts in Antibody Recognition of Defined Protein Antigens in a Schistosome-exposed Population The Journal of Infectious Diseases. Jul, 2008 | Pubmed ID: 18549316 The Secretome of the Filarial Parasite, Brugia Malayi: Proteomic Profile of Adult Excretory-secretory Products Molecular and Biochemical Parasitology. Jul, 2008 | Pubmed ID: 18439691 Cystatins from Filarial Parasites: Evolution, Adaptation and Function in the Host-parasite Relationship The International Journal of Biochemistry & Cell Biology. 2008 | Pubmed ID: 18249028 Alarming Dendritic Cells for Th2 Induction The Journal of Experimental Medicine. Jan, 2008 | Pubmed ID: 18195077 Cytokine Responses to Schistosoma Haematobium in a Zimbabwean Population: Contrasting Profiles for IFN-gamma, IL-4, IL-5 and IL-10 with Age BMC Infectious Diseases. 2007 | Pubmed ID: 18045464 CTLA-4 and CD4+ CD25+ Regulatory T Cells Inhibit Protective Immunity to Filarial Parasites in Vivo Journal of Immunology (Baltimore, Md. : 1950). Oct, 2007 | Pubmed ID: 17878360 Expansion and Activation of CD4(+)CD25(+) Regulatory T Cells in Heligmosomoides Polygyrus Infection European Journal of Immunology. Jul, 2007 | Pubmed ID: 17563918 Regulation of the Immune System in Metazoan Parasite Infections Novartis Foundation Symposium. 2007 | Pubmed ID: 17534075 O-methylated Glycans from Toxocara Are Specific Targets for Antibody Binding in Human and Animal Infections International Journal for Parasitology. Jan, 2007 | Pubmed ID: 17087964 IL-4R Signaling is Required to Induce IL-10 for the Establishment of T(h)2 Dominance International Immunology. Oct, 2006 | Pubmed ID: 16940042 Immuno-epidemiology of Human Schistosoma Haematobium Infection: Preferential IgG3 Antibody Responsiveness to a Recombinant Antigen Dependent on Age and Parasite Burden BMC Infectious Diseases. 2006 | Pubmed ID: 16764709 F4/80+ Alternatively Activated Macrophages Control CD4+ T Cell Hyporesponsiveness at Sites Peripheral to Filarial Infection Journal of Immunology (Baltimore, Md. : 1950). Jun, 2006 | Pubmed ID: 16709852 Molecular and Cellular Biology of Helminth Parasites IV International Journal for Parasitology. May, 2006 | Pubmed ID: 16620824 A New C-type Lectin Similar to the Human Immunoreceptor DC-SIGN Mediates Symbiont Acquisition by a Marine Nematode Applied and Environmental Microbiology. Apr, 2006 | Pubmed ID: 16598002 Regulatory T Cells Induced by Parasites and the Modulation of Allergic Responses Chemical Immunology and Allergy. 2006 | Pubmed ID: 16210910 Suppression of Allergic Airway Inflammation by Helminth-induced Regulatory T Cells The Journal of Experimental Medicine. Nov, 2005 | Pubmed ID: 16275759 Infections and Allergy - Helminths, Hygiene and Host Immune Regulation Current Opinion in Immunology. Dec, 2005 | Pubmed ID: 16202576 Praziquantel Treatment of Individuals Exposed to Schistosoma Haematobium Enhances Serological Recognition of Defined Parasite Antigens The Journal of Infectious Diseases. Sep, 2005 | Pubmed ID: 16107967 Removal of Regulatory T Cell Activity Reverses Hyporesponsiveness and Leads to Filarial Parasite Clearance in Vivo Journal of Immunology (Baltimore, Md. : 1950). Apr, 2005 | Pubmed ID: 15814720 Heterologous Expression of the Filarial Nematode Alt Gene Products Reveals Their Potential to Inhibit Immune Function BMC Biology. 2005 | Pubmed ID: 15788098 Bm-CPI-2, a Cystatin from Brugia Malayi Nematode Parasites, Differs from Caenorhabditis Elegans Cystatins in a Specific Site Mediating Inhibition of the Antigen-processing Enzyme AEP Molecular and Biochemical Parasitology. Feb, 2005 | Pubmed ID: 15664654 Chitinase and Fizz Family Members Are a Generalized Feature of Nematode Infection with Selective Upregulation of Ym1 and Fizz1 by Antigen-presenting Cells Infection and Immunity. Jan, 2005 | Pubmed ID: 15618176 Comparison of IgG-ELISA and IgG4-ELISA for Toxocara Serodiagnosis Acta Tropica. Jan, 2005 | Pubmed ID: 15589798 Th2 Induction by Nippostrongylus Secreted Antigens in Mice Deficient in B Cells, Eosinophils or MHC Class I-related Receptors Immunology Letters. Jan, 2005 | Pubmed ID: 15585312 Selective Maturation of Dendritic Cells by Nippostrongylus Brasiliensis-secreted Proteins Drives Th2 Immune Responses European Journal of Immunology. Nov, 2004 | Pubmed ID: 15468056 Helminth Parasites--masters of Regulation Immunological Reviews. Oct, 2004 | Pubmed ID: 15361235 Lymphatic Filariasis and Brugia Timori: Prospects for Elimination Trends in Parasitology. Aug, 2004 | Pubmed ID: 15246315 Resistance to Helminth Infection: the Case for Interleukin-5-dependent Mechanisms The Journal of Infectious Diseases. Aug, 2004 | Pubmed ID: 15243913 Linked Thioredoxin-glutathione Systems in Platyhelminths Trends in Parasitology. Jul, 2004 | Pubmed ID: 15193566 Signal Sequence Analysis of Expressed Sequence Tags from the Nematode Nippostrongylus Brasiliensis and the Evolution of Secreted Proteins in Parasites Genome Biology. 2004 | Pubmed ID: 15186490 Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an Unusual Lectin Domain from the Platyhelminth Parasite Echinococcus Granulosus The Biochemical Journal. Sep, 2004 | Pubmed ID: 15142032 Regulation of Allergy and Autoimmunity in Helminth Infection Clinical Reviews in Allergy & Immunology. Feb, 2004 | Pubmed ID: 14755074 Immune Regulation by Helminth Parasites: Cellular and Molecular Mechanisms Nature Reviews. Immunology. Sep, 2003 | Pubmed ID: 12949497 Abundant Larval Transcript-1 and -2 Genes from Brugia Malayi: Diversity of Genomic Environments but Conservation of 5' Promoter Sequences Functional in Caenorhabditis Elegans Molecular and Biochemical Parasitology. Nov-Dec, 2002 | Pubmed ID: 12467974 Homologues of Human Macrophage Migration Inhibitory Factor from a Parasitic Nematode. Gene Cloning, Protein Activity, and Crystal Structure The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12221083 Molecular Helminthology: an Integrated Approach The American Journal of Tropical Medicine and Hygiene. Apr, 2002 | Pubmed ID: 12164287 Full-length-enriched CDNA Libraries from Echinococcus Granulosus Contain Separate Populations of Oligo-capped and Trans-spliced Transcripts and a High Level of Predicted Signal Peptide Sequences Molecular and Biochemical Parasitology. Jul, 2002 | Pubmed ID: 12106871 の栽培 Chris J. C. Johnston1, Elaine Robertson1, Yvonne Harcus1, John R. Grainger2, Gillian Coakley1, Danielle J. Smyth1, Henry J. McSorley1, Rick Maizels1 1Institute of Immunology and Infection Research, University of Edinburgh, 2Manchester Collaborative Centre for Inflammation Research JoVE 52412 Immunologia e infezioni
の栽培 Chris J. C. Johnston1, Elaine Robertson1, Yvonne Harcus1, John R. Grainger2, Gillian Coakley1, Danielle J. Smyth1, Henry J. McSorley1, Rick Maizels1 1Institute of Immunology and Infection Research, University of Edinburgh, 2Manchester Collaborative Centre for Inflammation Research JoVE 52412 Immunologia e infezioni