Stephen R. Holdsworth Monash University Biography Publications Institution JoVE Articles Stephen R. Holdsworth has not added a biography. If you are Stephen R. Holdsworth and would like to personalize this page please email our Author Liaison for assistance. Publications Deoxyribonuclease 1 Reduces Pathogenic Effects of Cigarette Smoke Exposure in the Lung Scientific Reports. Sep, 2017 | Pubmed ID: 28935869 ANCA-Associated Vasculitis: Pathogenesis, Models, and Preclinical Testing Seminars in Nephrology. Sep, 2017 | Pubmed ID: 28863790 Dominant Protection from HLA-linked Autoimmunity by Antigen-specific Regulatory T Cells Nature. 05, 2017 | Pubmed ID: 28467828 T Cell Receptor Assessment in Autoimmune Disease Requires Access to the Most Adjacent Immunologically Active Organ Journal of Autoimmunity. Jul, 2017 | Pubmed ID: 28318808 Interleukin-17RA Promotes Humoral Responses and Glomerular Injury in Experimental Rapidly Progressive Glomerulonephritis Nephron. 2017 | Pubmed ID: 27941331 Induced Regulatory T Cells Are Phenotypically Unstable and Do Not Protect Mice from Rapidly Progressive Glomerulonephritis Immunology. Jan, 2017 | Pubmed ID: 27606831 Activated Renal Dendritic Cells Cross Present Intrarenal Antigens After Ischemia-Reperfusion Injury Transplantation. May, 2017 | Pubmed ID: 27495751 CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN Journal of the American Society of Nephrology : JASN. Jan, 2017 | Pubmed ID: 27288012 The NLRP3 Inflammasome in Kidney Disease and Autoimmunity Nephrology (Carlton, Vic.). Sep, 2016 | Pubmed ID: 27011059 Biologics for the Treatment of Autoimmune Renal Diseases Nature Reviews. Nephrology. Apr, 2016 | Pubmed ID: 26949177 Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase Journal of Immunology Research. 2016 | Pubmed ID: 26904693 Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis Journal of the American Society of Nephrology : JASN. May, 2016 | Pubmed ID: 26374606 Regulatory T Cells in Immune-mediated Renal Disease Nephrology (Carlton, Vic.). Feb, 2016 | Pubmed ID: 26206106 Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment Journal of the American Society of Nephrology : JASN. Mar, 2016 | Pubmed ID: 26116356 Myeloperoxidase Peptide-Based Nasal Tolerance in Experimental ANCA-Associated GN Journal of the American Society of Nephrology : JASN. Feb, 2016 | Pubmed ID: 26047792 Targeting IL-17 and IL-23 in Immune Mediated Renal Disease Current Medicinal Chemistry. 2015 | Pubmed ID: 26521930 The Lung Immune Response to Bacteria in Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. Oct, 2015 | Pubmed ID: 26426789 Renal Participation of Myeloperoxidase in Antineutrophil Cytoplasmic Antibody (ANCA)-associated Glomerulonephritis Kidney International. Nov, 2015 | Pubmed ID: 26176828 Programmed Death 1 and Its Ligands Do Not Limit Experimental Foreign Antigen-induced Immune Complex Glomerulonephritis Nephrology (Carlton, Vic.). Dec, 2015 | Pubmed ID: 26043977 Cytokines: Names and Numbers You Should Care About Clinical Journal of the American Society of Nephrology : CJASN. Dec, 2015 | Pubmed ID: 25941193 FMS-like Tyrosine Kinase 3 Ligand Treatment Does Not Ameliorate Experimental Rapidly Progressive Glomerulonephritis PloS One. 2015 | Pubmed ID: 25849330 Nontypeable Haemophilus Influenzae Induces Sustained Lung Oxidative Stress and Protease Expression PloS One. 2015 | Pubmed ID: 25793977 Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase Arthritis & Rheumatology (Hoboken, N.J.). Jul, 2015 | Pubmed ID: 25777776 Mouse Models of Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis Current Pharmaceutical Design. 2015 | Pubmed ID: 25777754 T Cell Mediated Autoimmune Glomerular Disease in Mice Current Protocols in Immunology. Nov, 2014 | Pubmed ID: 25367126 Glomerulonephritis Induced by Heterologous Anti-GBM Globulin As a Planted Foreign Antigen Current Protocols in Immunology. Aug, 2014 | Pubmed ID: 25081909 FcγRIIB Regulates T-cell Autoreactivity, ANCA Production, and Neutrophil Activation to Suppress Anti-myeloperoxidase Glomerulonephritis Kidney International. Dec, 2014 | Pubmed ID: 24869670 Endogenous Myeloperoxidase is a Mediator of Joint Inflammation and Damage in Experimental Arthritis Arthritis & Rheumatology (Hoboken, N.J.). Apr, 2014 | Pubmed ID: 24757143 Innate IL-17A-producing Leukocytes Promote Acute Kidney Injury Via Inflammasome and Toll-like Receptor Activation The American Journal of Pathology. May, 2014 | Pubmed ID: 24631024 Histopathologic and Clinical Predictors of Kidney Outcomes in ANCA-associated Vasculitis American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. Feb, 2014 | Pubmed ID: 24183110 MicroRNA-155 a New Therapeutic Target in Crescentic GN Journal of the American Society of Nephrology : JASN. Dec, 2013 | Pubmed ID: 24158984 Myeloperoxidase (MPO)-specific CD4+ T Cells Contribute to MPO-anti-neutrophil Cytoplasmic Antibody (ANCA) Associated Glomerulonephritis Cellular Immunology. Mar, 2013 | Pubmed ID: 23665205 Neutrophil Myeloperoxidase Regulates T-cell-driven Tissue Inflammation in Mice by Inhibiting Dendritic Cell Function Blood. May, 2013 | Pubmed ID: 23509155 Reply: To PMID 23142009 The Journal of Allergy and Clinical Immunology. Apr, 2013 | Pubmed ID: 23453686 The HLA-DRB1*15:01-restricted Goodpasture's T Cell Epitope Induces GN Journal of the American Society of Nephrology : JASN. Feb, 2013 | Pubmed ID: 23411782 Thymic Deletion and Regulatory T Cells Prevent Antimyeloperoxidase GN Journal of the American Society of Nephrology : JASN. Mar, 2013 | Pubmed ID: 23393320 Chest Pain and Exacerbations of Bronchiectasis International Journal of General Medicine. 2012 | Pubmed ID: 23271921 慢性閉塞性肺疾患患者におけるインフルエンザ菌への肺の T 細胞の反応。 The Journal of Allergy and Clinical Immunology. Nov, 2012 | Pubmed ID: 23142009 Mast Cells Contribute to Peripheral Tolerance and Attenuate Autoimmune Vasculitis Journal of the American Society of Nephrology : JASN. Dec, 2012 | Pubmed ID: 23138486 The Immunodominant Myeloperoxidase T-cell Epitope Induces Local Cell-mediated Injury in Antimyeloperoxidase Glomerulonephritis Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012 | Pubmed ID: 22955884 Mast Cell Activation and Degranulation Promotes Renal Fibrosis in Experimental Unilateral Ureteric Obstruction Kidney International. Sep, 2012 | Pubmed ID: 22673890 Endogenous Tim-1 (Kim-1) Promotes T-cell Responses and Cell-mediated Injury in Experimental Crescentic Glomerulonephritis Kidney International. May, 2012 | Pubmed ID: 22205357 Renal Dendritic Cells Adopt a Pro-inflammatory Phenotype in Obstructive Uropathy to Activate T Cells but Do Not Directly Contribute to Fibrosis The American Journal of Pathology. Jan, 2012 | Pubmed ID: 22079432 Mast Cells Mediate Acute Kidney Injury Through the Production of TNF Journal of the American Society of Nephrology : JASN. Dec, 2011 | Pubmed ID: 22021718 Tim-1 Promotes Cisplatin Nephrotoxicity American Journal of Physiology. Renal Physiology. Nov, 2011 | Pubmed ID: 21835770 Interleukin-17A Promotes Early but Attenuates Established Disease in Crescentic Glomerulonephritis in Mice The American Journal of Pathology. Sep, 2011 | Pubmed ID: 21741931 The Emergence of TH17 Cells As Effectors of Renal Injury Journal of the American Society of Nephrology : JASN. Feb, 2011 | Pubmed ID: 21289213 The IL-27 Receptor Has Biphasic Effects in Crescentic Glomerulonephritis Mediated Through Th1 Responses The American Journal of Pathology. Feb, 2011 | Pubmed ID: 21281790 Endogenous Foxp3(+) T-regulatory Cells Suppress Anti-glomerular Basement Membrane Nephritis Kidney International. May, 2011 | Pubmed ID: 21248715 Toll-like Receptor 2 Induces Th17 Myeloperoxidase Autoimmunity While Toll-like Receptor 9 Drives Th1 Autoimmunity in Murine Vasculitis Arthritis and Rheumatism. Apr, 2011 | Pubmed ID: 21190299 The Th17-defining Transcription Factor RORγt Promotes Glomerulonephritis Journal of the American Society of Nephrology : JASN. Mar, 2011 | Pubmed ID: 21183590 Lung Diffusing Capacity in Adult Bronchiectasis: a Longitudinal Study Respiratory Care. Dec, 2010 | Pubmed ID: 21122177 Toll-like Receptor 9 Enhances Nephritogenic Immunity and Glomerular Leukocyte Recruitment, Exacerbating Experimental Crescentic Glomerulonephritis The American Journal of Pathology. Nov, 2010 | Pubmed ID: 20847283 Intrinsic Renal Cell and Leukocyte-derived TLR4 Aggravate Experimental Anti-MPO Glomerulonephritis Kidney International. Dec, 2010 | Pubmed ID: 20844472 Review: T Helper 17 Cells: Their Role in Glomerulonephritis Nephrology (Carlton, Vic.). Aug, 2010 | Pubmed ID: 20649870 Th17 Cells Promote Autoimmune Anti-myeloperoxidase Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jun, 2010 | Pubmed ID: 20299361 Th1 and Th17 Cells Induce Proliferative Glomerulonephritis Journal of the American Society of Nephrology : JASN. Dec, 2009 | Pubmed ID: 19820122 Atorvastatin Enhances Humoral Immune Responses but Does Not Alter Renal Injury in Experimental Crescentic Glomerulonephritis Nephrology (Carlton, Vic.). Oct, 2009 | Pubmed ID: 19796023 Endogenous CD100 Promotes Glomerular Injury and Macrophage Recruitment in Experimental Crescentic Glomerulonephritis Immunology. Sep, 2009 | Pubmed ID: 19689741 IL-1RI Deficiency Ameliorates Early Experimental Renal Interstitial Fibrosis Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Oct, 2009 | Pubmed ID: 19465557 Phenotypes of Adult Bronchiectasis: Onset of Productive Cough in Childhood and Adulthood COPD. Apr, 2009 | Pubmed ID: 19378226 IL-23, Not IL-12, Directs Autoimmunity to the Goodpasture Antigen Journal of the American Society of Nephrology : JASN. May, 2009 | Pubmed ID: 19357249 Role of Mast Cells in Progressive Renal Diseases Journal of the American Society of Nephrology : JASN. Dec, 2008 | Pubmed ID: 18776124 Advances in the Pathogenesis of Goodpasture's Disease: from Epitopes to Autoantibodies to Effector T Cells Journal of Autoimmunity. Nov, 2008 | Pubmed ID: 18502098 T-bet Deficiency Attenuates Renal Injury in Experimental Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Mar, 2008 | Pubmed ID: 18235099 Distinct in Vivo Roles of CD80 and CD86 in the Effector T-cell Responses Inducing Antigen-induced Arthritis Immunology. Aug, 2008 | Pubmed ID: 18217945 Intrarenal Antigens Activate CD4+ Cells Via Co-stimulatory Signals from Dendritic Cells Journal of the American Society of Nephrology : JASN. Mar, 2008 | Pubmed ID: 18184859 Leukocytes in Glomerular Injury Seminars in Immunopathology. Nov, 2007 | Pubmed ID: 17938927 Cytokines in Glomerulonephritis Seminars in Nephrology. May, 2007 | Pubmed ID: 17533006 Microbiologic Follow-up Study in Adult Bronchiectasis Respiratory Medicine. Aug, 2007 | Pubmed ID: 17467966 Endogenous Myeloperoxidase Promotes Neutrophil-mediated Renal Injury, but Attenuates T Cell Immunity Inducing Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Mar, 2007 | Pubmed ID: 17267745 CD100 Enhances Dendritic Cell and CD4+ Cell Activation Leading to Pathogenetic Humoral Responses and Immune Complex Glomerulonephritis Journal of Immunology (Baltimore, Md. : 1950). Sep, 2006 | Pubmed ID: 16920982 Anti-neutrophil Cytoplasmic Antibodies and Effector CD4+ Cells Play Nonredundant Roles in Anti-myeloperoxidase Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jul, 2006 | Pubmed ID: 16769746 Characterisation of the Onset and Presenting Clinical Features of Adult Bronchiectasis Respiratory Medicine. Dec, 2006 | Pubmed ID: 16650970 T Cells in Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. May, 2006 | Pubmed ID: 16624930 Inducible Co-stimulatory Molecule Ligand is Protective During the Induction and Effector Phases of Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Apr, 2006 | Pubmed ID: 16540559 The Isolation and Purification of Biologically Active Recombinant and Native Autoantigens for the Study of Autoimmune Disease Journal of Immunological Methods. Jan, 2006 | Pubmed ID: 16388818 A Pathogenetic Role for Mast Cells in Experimental Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jan, 2006 | Pubmed ID: 16319187 Outcome in Adult Bronchiectasis COPD. Mar, 2005 | Pubmed ID: 17136958 Granulocyte Macrophage Colony-stimulating Factor Expression by Both Renal Parenchymal and Immune Cells Mediates Murine Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Sep, 2005 | Pubmed ID: 16033860 Leukocyte Phenotype and Function Predicts Infection Risk in Renal Transplant Recipients Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Oct, 2005 | Pubmed ID: 16030032 CD80 and CD86 Costimulatory Molecules Regulate Crescentic Glomerulonephritis by Different Mechanisms Kidney International. Aug, 2005 | Pubmed ID: 16014035 Glomerular Expression of CD80 and CD86 is Required for Leukocyte Accumulation and Injury in Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jul, 2005 | Pubmed ID: 15944341 IL-12p40 and IL-18 in Crescentic Glomerulonephritis: IL-12p40 is the Key Th1-defining Cytokine Chain, Whereas IL-18 Promotes Local Inflammation and Leukocyte Recruitment Journal of the American Society of Nephrology : JASN. Jul, 2005 | Pubmed ID: 15888563 Experimental Autoimmune Goodpasture's Disease: a Pathogenetic Role for Both Effector Cells and Antibody in Injury Kidney International. Feb, 2005 | Pubmed ID: 15673304 Endogenous IL-13 Limits Humoral Responses and Injury in Experimental Glomerulonephritis but Does Not Regulate Th1 Cell-mediated Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Sep, 2004 | Pubmed ID: 15339986 Fibrin Independent Proinflammatory Effects of Tissue Factor in Experimental Crescentic Glomerulonephritis Kidney International. Aug, 2004 | Pubmed ID: 15253718 Experimental Autoimmune Anti-glomerular Basement Membrane Glomerulonephritis: a Protective Role for IFN-gamma Journal of the American Society of Nephrology : JASN. Jul, 2004 | Pubmed ID: 15213264 An IL-12-independent Role for CD40-CD154 in Mediating Effector Responses: Studies in Cell-mediated Glomerulonephritis and Dermal Delayed-type Hypersensitivity Journal of Immunology (Baltimore, Md. : 1950). Jul, 2004 | Pubmed ID: 15210767 Ex Vivo Lymphocyte Proliferative Function is Severely Inhibited in Renal Transplant Patients on Mycophenolate Mofetil Treatment Transplant Immunology. Jun-Jul, 2004 | Pubmed ID: 15203129 Leukocyte-derived Interleukin-1beta Interacts with Renal Interleukin-1 Receptor I to Promote Renal Tumor Necrosis Factor and Glomerular Injury in Murine Crescentic Glomerulonephritis The American Journal of Pathology. Jun, 2004 | Pubmed ID: 15161633 Contributions of IL-1beta and IL-1alpha to Crescentic Glomerulonephritis in Mice Journal of the American Society of Nephrology : JASN. Apr, 2004 | Pubmed ID: 15034093 The Role of Flow Cytometric ANCA Detection in Screening for Acute Pauci-immune Crescentic Glomerulonephritis Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Feb, 2004 | Pubmed ID: 14736960 Intrinsic Renal Cell Expression of CD40 Directs Th1 Effectors Inducing Experimental Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Nov, 2003 | Pubmed ID: 14569091 Intrinsic Renal Cells Are the Major Source of Tumor Necrosis Factor Contributing to Renal Injury in Murine Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jul, 2003 | Pubmed ID: 12819238 T Cells in Glomerulonephritis Springer Seminars in Immunopathology. May, 2003 | Pubmed ID: 12778334 Plasminogen Activator Inhibitor-1 is a Significant Determinant of Renal Injury in Experimental Crescentic Glomerulonephritis Journal of the American Society of Nephrology : JASN. Jun, 2003 | Pubmed ID: 12761249 Laboratory Assessment of Immune Function in Renal Transplant Patients Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. May, 2003 | Pubmed ID: 12686675 Adaptive Immunity to Nontypeable Haemophilus Influenzae American Journal of Respiratory and Critical Care Medicine. Feb, 2003 | Pubmed ID: 12433671 IFN-gamma Production by Intrinsic Renal Cells and Bone Marrow-derived Cells is Required for Full Expression of Crescentic Glomerulonephritis in Mice Journal of Immunology (Baltimore, Md. : 1950). Apr, 2002 | Pubmed ID: 11937574 The Requirement for Granulocyte-macrophage Colony-stimulating Factor and Granulocyte Colony-stimulating Factor in Leukocyte-mediated Immune Glomerular Injury Journal of the American Society of Nephrology : JASN. Feb, 2002 | Pubmed ID: 11805162 共焦点顕微鏡を用いた可視化マクロファージ細胞外トラップ Roleen Sharma1,2, Kim M. O'Sullivan2, Stephen R. Holdsworth2, Philip G. Bardin1,2, Paul T. King1,2 1Monash Lung and Sleep, Monash Medical Centre, 2Monash University JoVE 56459 Immunologia e infezioni
共焦点顕微鏡を用いた可視化マクロファージ細胞外トラップ Roleen Sharma1,2, Kim M. O'Sullivan2, Stephen R. Holdsworth2, Philip G. Bardin1,2, Paul T. King1,2 1Monash Lung and Sleep, Monash Medical Centre, 2Monash University JoVE 56459 Immunologia e infezioni