Thomas Tuschl Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology Rockefeller University Biography Publications Institution JoVE Articles Thomas Tuschl has not added a biography. If you are Thomas Tuschl and would like to personalize this page please email our Author Liaison for assistance. Publications The Viral and Cellular MicroRNA Targetome in Lymphoblastoid Cell Lines PLoS Pathogens. Jan, 2012 | Pubmed ID: 22291592 Identification of RNA-protein Interaction Networks Using PAR-CLIP Wiley Interdisciplinary Reviews. RNA. Dec, 2011 | Pubmed ID: 22213601 Viral MicroRNA Targetome of KSHV-infected Primary Effusion Lymphoma Cell Lines Cell Host & Microbe. Nov, 2011 | Pubmed ID: 22100165 RNA Targets of Wild-type and Mutant FET Family Proteins Nature Structural & Molecular Biology. Dec, 2011 | Pubmed ID: 22081015 New Insights in the Mechanism of MicroRNA-mediated Target Repression Nature Structural & Molecular Biology. Nov, 2011 | Pubmed ID: 22056803 Genome-wide Identification of MicroRNA Targets in Human ES Cells Reveals a Role for MiR-302 in Modulating BMP Response Genes & Development. Oct, 2011 | Pubmed ID: 22012620 FOXO1 is an Essential Regulator of Pluripotency in Human Embryonic Stem Cells Nature Cell Biology. Sep, 2011 | Pubmed ID: 21804543 MicroRNA-24 Regulates Vascularity After Myocardial Infarction Circulation. Aug, 2011 | Pubmed ID: 21788589 RNA-ligase-dependent Biases in MiRNA Representation in Deep-sequenced Small RNA CDNA Libraries RNA (New York, N.Y.). Sep, 2011 | Pubmed ID: 21775473 Integrative Regulatory Mapping Indicates That the RNA-binding Protein HuR Couples Pre-mRNA Processing and MRNA Stability Molecular Cell. Aug, 2011 | Pubmed ID: 21723170 Small RNA Sequencing and Functional Characterization Reveals MicroRNA-143 Tumor Suppressor Activity in Liposarcoma Cancer Research. Sep, 2011 | Pubmed ID: 21693658 MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing Cancer Research. Jul, 2011 | Pubmed ID: 21586611 Multimeric Assembly and Biochemical Characterization of the Trax-translin Endonuclease Complex Nature Structural & Molecular Biology. Jun, 2011 | Pubmed ID: 21552261 Deep Sequencing of Small RNAs Specifically Associated with Arabidopsis AGO1 and AGO4 Uncovers New AGO Functions The Plant Journal : for Cell and Molecular Biology. Jul, 2011 | Pubmed ID: 21457371 Combined Characterization of MicroRNA and MRNA Profiles Delineates Early Differentiation Pathways of CD133+ and CD34+ Hematopoietic Stem and Progenitor Cells Stem Cells (Dayton, Ohio). May, 2011 | Pubmed ID: 21394831 MicroRNAs MiR-17, MiR-20a, and MiR-106b Act in Concert to Modulate E2F Activity on Cell Cycle Arrest During Neuronal Lineage Differentiation of USSC PloS One. 2011 | Pubmed ID: 21283765 MiRNAs in Human Cancer The Journal of Pathology. Jan, 2011 | Pubmed ID: 21125669 Structural and Functional Insights into 5'-ppp RNA Pattern Recognition by the Innate Immune Receptor RIG-I Nature Structural & Molecular Biology. Jul, 2010 | Pubmed ID: 20581823 Differential Regulation of Mature and Precursor MicroRNA Expression by NMDA and Metabotropic Glutamate Receptor Activation During LTP in the Adult Dentate Gyrus in Vivo The European Journal of Neuroscience. Feb, 2010 | Pubmed ID: 20384810 Transcriptome-wide Identification of RNA-binding Protein and MicroRNA Target Sites by PAR-CLIP Cell. Apr, 2010 | Pubmed ID: 20371350 Absolute Quantification of MicroRNAs by Using a Universal Reference RNA (New York, N.Y.). Dec, 2009 | Pubmed ID: 19861428 Nucleation, Propagation and Cleavage of Target RNAs in Ago Silencing Complexes Nature. Oct, 2009 | Pubmed ID: 19812667 Characterization of Small RNAs in Aplysia Reveals a Role for MiR-124 in Constraining Synaptic Plasticity Through CREB Neuron. Sep, 2009 | Pubmed ID: 19778509 The Muscle-specific MicroRNA MiR-206 Blocks Human Rhabdomyosarcoma Growth in Xenotransplanted Mice by Promoting Myogenic Differentiation The Journal of Clinical Investigation. Aug, 2009 | Pubmed ID: 19620785 Recognition of 5' Triphosphate by RIG-I Helicase Requires Short Blunt Double-stranded RNA As Contained in Panhandle of Negative-strand Virus Immunity. Jul, 2009 | Pubmed ID: 19576794 The PTEN-regulating MicroRNA MiR-26a is Amplified in High-grade Glioma and Facilitates Gliomagenesis in Vivo Genes & Development. Jun, 2009 | Pubmed ID: 19487573 MiRNA in Situ Hybridization in Formaldehyde and EDC-fixed Tissues Nature Methods. Feb, 2009 | Pubmed ID: 19137005 DGCR8-dependent MicroRNA Biogenesis is Essential for Skin Development Proceedings of the National Academy of Sciences of the United States of America. Jan, 2009 | Pubmed ID: 19114655 A Drosophila Pasha Mutant Distinguishes the Canonical MicroRNA and Mirtron Pathways Molecular and Cellular Biology. Feb, 2009 | Pubmed ID: 19047376 Structure of an Argonaute Silencing Complex with a Seed-containing Guide DNA and Target RNA Duplex Nature. Dec, 2008 | Pubmed ID: 19092929 MicroRNA-21 Contributes to Myocardial Disease by Stimulating MAP Kinase Signalling in Fibroblasts Nature. Dec, 2008 | Pubmed ID: 19043405 Molecular Characterization of Human Argonaute-containing Ribonucleoprotein Complexes and Their Bound Target MRNAs RNA (New York, N.Y.). Dec, 2008 | Pubmed ID: 18978028 Structure of the Guide-strand-containing Argonaute Silencing Complex Nature. Nov, 2008 | Pubmed ID: 18754009 Elevated Expression of the MiR-17-92 Polycistron and MiR-21 in Hepadnavirus-associated Hepatocellular Carcinoma Contributes to the Malignant Phenotype The American Journal of Pathology. Sep, 2008 | Pubmed ID: 18688024 MicroRNA-mediated Down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg Cells: a Potential Pathogenetic Lesion in Hodgkin Lymphomas The American Journal of Pathology. Jul, 2008 | Pubmed ID: 18583325 MicroRNA-155 is a Negative Regulator of Activation-induced Cytidine Deaminase Immunity. May, 2008 | Pubmed ID: 18450484 The Growing Catalog of Small RNAs and Their Association with Distinct Argonaute/Piwi Family Members Development (Cambridge, England). Apr, 2008 | Pubmed ID: 18287206 Identification of MicroRNAs and Other Small Regulatory RNAs Using CDNA Library Sequencing Methods (San Diego, Calif.). Jan, 2008 | Pubmed ID: 18158127 Strand-specific 5'-O-methylation of SiRNA Duplexes Controls Guide Strand Selection and Targeting Specificity RNA (New York, N.Y.). Feb, 2008 | Pubmed ID: 18094121 Repeat-associated SiRNAs Cause Chromatin Silencing of Retrotransposons in the Drosophila Melanogaster Germline Nucleic Acids Research. 2007 | Pubmed ID: 17702759 Reactions of Phosphate and Phosphorothiolate Diesters with Nucleophiles: Comparison of Transition State Structures Organic & Biomolecular Chemistry. Aug, 2007 | Pubmed ID: 17637971 Cellular Cofactors Affecting Hepatitis C Virus Infection and Replication Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17616579 A Mammalian MicroRNA Expression Atlas Based on Small RNA Library Sequencing Cell. Jun, 2007 | Pubmed ID: 17604727 Specificity, Duplex Degradation and Subcellular Localization of Antagomirs Nucleic Acids Research. 2007 | Pubmed ID: 17439965 Quantitative Technologies Establish a Novel MicroRNA Profile of Chronic Lymphocytic Leukemia Blood. Jun, 2007 | Pubmed ID: 17327404 Cucumber Mosaic Virus-encoded 2b Suppressor Inhibits Arabidopsis Argonaute1 Cleavage Activity to Counter Plant Defense Genes & Development. Dec, 2006 | Pubmed ID: 17158744 Gene Silencing with SiRNA Duplexes Composed of Target-mRNA-complementary and Partially Palindromic or Partially Complementary Single-stranded SiRNAs RNA Biology. Apr, 2006 | Pubmed ID: 17114944 A Potential Protein-RNA Recognition Event Along the RISC-loading Pathway from the Structure of A. Aeolicus Argonaute with Externally Bound SiRNA Structure (London, England : 1993). Oct, 2006 | Pubmed ID: 17027504 On the Art of Identifying Effective and Specific SiRNAs Nature Methods. Sep, 2006 | Pubmed ID: 16929310 A Novel Class of Small RNAs Bind to MILI Protein in Mouse Testes Nature. Jul, 2006 | Pubmed ID: 16751777 Cloning of Small RNA Molecules Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [et Al.]. Nov, 2005 | Pubmed ID: 18265364 Specific RNAi Mediated Gene Knockdown in Zebrafish Cell Lines RNA Biology. Jul-Sep, 2005 | Pubmed ID: 17114924 Identification of Novel Argonaute-associated Proteins Current Biology : CB. Dec, 2005 | Pubmed ID: 16289642 Identification of Clustered MicroRNAs Using an Ab Initio Prediction Method BMC Bioinformatics. 2005 | Pubmed ID: 16274478 Silencing of MicroRNAs in Vivo with 'antagomirs' Nature. Dec, 2005 | Pubmed ID: 16258535 Identification and Characterization of Small RNAs Involved in RNA Silencing FEBS Letters. Oct, 2005 | Pubmed ID: 16153643 Crystal Structure of A. Aeolicus Argonaute, a Site-specific DNA-guided Endoribonuclease, Provides Insights into RISC-mediated MRNA Cleavage Molecular Cell. Aug, 2005 | Pubmed ID: 16061186 Antisense-mediated Depletion Reveals Essential and Specific Functions of MicroRNAs in Drosophila Development Cell. Jul, 2005 | Pubmed ID: 15989958 The Developmental MiRNA Profiles of Zebrafish As Determined by Small RNA Cloning Genes & Development. Jun, 2005 | Pubmed ID: 15937218 Clustering and Conservation Patterns of Human MicroRNAs Nucleic Acids Research. 2005 | Pubmed ID: 15891114 Structural Basis for 5'-end-specific Recognition of Guide RNA by the A. Fulgidus Piwi Protein Nature. Mar, 2005 | Pubmed ID: 15800629 Identification of MicroRNAs of the Herpesvirus Family Nature Methods. Apr, 2005 | Pubmed ID: 15782219 Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy Science (New York, N.Y.). Jan, 2005 | Pubmed ID: 15591165 The Human DiGeorge Syndrome Critical Region Gene 8 and Its D. Melanogaster Homolog Are Required for MiRNA Biogenesis Current Biology : CB. Dec, 2004 | Pubmed ID: 15589161 A Pancreatic Islet-specific MicroRNA Regulates Insulin Secretion Nature. Nov, 2004 | Pubmed ID: 15538371 Human MicroRNA Targets PLoS Biology. Nov, 2004 | Pubmed ID: 15502875 Mechanisms of Gene Silencing by Double-stranded RNA Nature. Sep, 2004 | Pubmed ID: 15372041 RNA Interference by Osmotic Lysis of Pinosomes: Liposome-independent Transfection of SiRNAs into Mammalian Cells BioTechniques. Jul, 2004 | Pubmed ID: 15283206 Human Argonaute2 Mediates RNA Cleavage Targeted by MiRNAs and SiRNAs Molecular Cell. Jul, 2004 | Pubmed ID: 15260970 SiRNA Selection Server: an Automated SiRNA Oligonucleotide Prediction Server Nucleic Acids Research. Jul, 2004 | Pubmed ID: 15215365 The Human 18S U11/U12 SnRNP Contains a Set of Novel Proteins Not Found in the U2-dependent Spliceosome RNA (New York, N.Y.). Jun, 2004 | Pubmed ID: 15146077 Identification of Virus-encoded MicroRNAs Science (New York, N.Y.). Apr, 2004 | Pubmed ID: 15118162 RISC is a 5' Phosphomonoester-producing RNA Endonuclease Genes & Development. May, 2004 | Pubmed ID: 15105377 SiRNAs: Applications in Functional Genomics and Potential As Therapeutics Nature Reviews. Drug Discovery. Apr, 2004 | Pubmed ID: 15060527 Sequence-specific Inhibition of MicroRNA- and SiRNA-induced RNA Silencing RNA (New York, N.Y.). Mar, 2004 | Pubmed ID: 14970398 MicroRNA Targets in Drosophila Genome Biology. 2003 | Pubmed ID: 14709173 Analysis of Mammalian Gene Function Using Small Interfering RNAs Nucleic Acids Research. Supplement (2001). 2003 | Pubmed ID: 14510516 The Small RNA Profile During Drosophila Melanogaster Development Developmental Cell. Aug, 2003 | Pubmed ID: 12919683 Sequence, Chemical, and Structural Variation of Small Interfering RNAs and Short Hairpin RNAs and the Effect on Mammalian Gene Silencing Antisense & Nucleic Acid Drug Development. Apr, 2003 | Pubmed ID: 12804036 A Uniform System for MicroRNA Annotation RNA (New York, N.Y.). Mar, 2003 | Pubmed ID: 12592000 New MicroRNAs from Mouse and Human RNA (New York, N.Y.). Feb, 2003 | Pubmed ID: 12554859 Functional Genomics: RNA Sets the Standard Nature. Jan, 2003 | Pubmed ID: 12529623 Small Interfering RNAs: a Revolutionary Tool for the Analysis of Gene Function and Gene Therapy Molecular Interventions. Jun, 2002 | Pubmed ID: 14993376 Single-stranded Antisense SiRNAs Guide Target RNA Cleavage in RNAi Cell. Sep, 2002 | Pubmed ID: 12230974 Analysis of Gene Function in Somatic Mammalian Cells Using Small Interfering RNAs Methods (San Diego, Calif.). Feb, 2002 | Pubmed ID: 12054897 Identification of Tissue-specific MicroRNAs from Mouse Current Biology : CB. Apr, 2002 | Pubmed ID: 12007417 Expanding Small RNA Interference Nature Biotechnology. May, 2002 | Pubmed ID: 11981553 PAR-Clip - En metod för att identifiera transkriptom hela bindningar på RNA-proteiner Markus Hafner1, Markus Landthaler2, Lukas Burger3, Mohsen Khorshid3, Jean Hausser4, Philipp Berninger4, Andrea Rothballer1, Manuel Ascano1, Anna-Carina Jungkamp2, Mathias Munschauer2, Alexander Ulrich1, Greg S. Wardle1, Scott Dewell5, Mihaela Zavolan3, Thomas Tuschl1 1Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, Rockefeller University, 2Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine, 3Biozentrum der Universität Basel and Swiss Institute of Bioinformatics (SIB), 4Biozentrum der Universität Basel and Swiss Institute of Bioinformatics (SIB), 5Genomics Resource Center, Rockefeller University JoVE 2034 Biologia
PAR-Clip - En metod för att identifiera transkriptom hela bindningar på RNA-proteiner Markus Hafner1, Markus Landthaler2, Lukas Burger3, Mohsen Khorshid3, Jean Hausser4, Philipp Berninger4, Andrea Rothballer1, Manuel Ascano1, Anna-Carina Jungkamp2, Mathias Munschauer2, Alexander Ulrich1, Greg S. Wardle1, Scott Dewell5, Mihaela Zavolan3, Thomas Tuschl1 1Howard Hughes Medical Institute, Laboratory of RNA Molecular Biology, Rockefeller University, 2Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine, 3Biozentrum der Universität Basel and Swiss Institute of Bioinformatics (SIB), 4Biozentrum der Universität Basel and Swiss Institute of Bioinformatics (SIB), 5Genomics Resource Center, Rockefeller University JoVE 2034 Biologia