William L. Dewey Pharmacology and Toxicology Virginia Commonwealth University Biography Publications Institution JoVE Articles William L. Dewey has not added a biography. If you are William L. Dewey and would like to personalize this page please email our Author Liaison for assistance. Publications Ethanol Reversal of Cellular Tolerance to Morphine in Rat Locus Coeruleus Neurons Molecular Pharmacology. Aug, 2013 | Pubmed ID: 23716621 Electrophysiological Characteristics of Enteric Neurons Isolated from the Immortomouse Digestive Diseases and Sciences. Jun, 2013 | Pubmed ID: 23371009 Design, Synthesis, and Biological Evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan Derivatives As Peripheral Selective μ Opioid Receptor Agents Journal of Medicinal Chemistry. Nov, 2012 | Pubmed ID: 23116124 Morphine Decreases Enteric Neuron Excitability Via Inhibition of Sodium Channels PloS One. 2012 | Pubmed ID: 23028881 Contribution of Acid Sphingomyelinase in the Periaqueductal Gray Region to Morphine-induced Analgesia in Mice Neuroreport. Sep, 2012 | Pubmed ID: 22825003 Evidence for the Putative Cannabinoid Receptor (GPR55)-mediated Inhibitory Effects on Intestinal Contractility in Mice Pharmacology. 2012 | Pubmed ID: 22759743 Production and Actions of the Anandamide Metabolite Prostamide E2 in the Renal Medulla The Journal of Pharmacology and Experimental Therapeutics. Sep, 2012 | Pubmed ID: 22685343 6β-N-heterocyclic Substituted Naltrexamine Derivative NAP As a Potential Lead to Develop Peripheral Mu Opioid Receptor Selective Antagonists Bioorganic & Medicinal Chemistry Letters. Jul, 2012 | Pubmed ID: 22683223 Morphine Efficacy is Altered in Conditional HIV-1 Tat Transgenic Mice European Journal of Pharmacology. Aug, 2012 | Pubmed ID: 22659585 Differences in the Characteristics of Tolerance to μ-opioid Receptor Agonists in the Colon from Wild Type and β-arrestin2 Knockout Mice European Journal of Pharmacology. Jun, 2012 | Pubmed ID: 22521552 Opioid-induced Hypernociception is Associated with Hyperexcitability and Altered Tetrodotoxin-resistant Na+ Channel Function of Dorsal Root Ganglia American Journal of Physiology. Cell Physiology. Apr, 2012 | Pubmed ID: 22189556 The Role of β-arrestin2 in the Mechanism of Morphine Tolerance in the Mouse and Guinea Pig Gastrointestinal Tract The Journal of Pharmacology and Experimental Therapeutics. Mar, 2012 | Pubmed ID: 22129596 Characterization of 6α- and 6β-N-heterocyclic Substituted Naltrexamine Derivatives As Novel Leads to Development of Mu Opioid Receptor Selective Antagonists ACS Chemical Neuroscience. Jul, 2011 | Pubmed ID: 22816021 Chronic Neuropathic Pain in Mice Reduces μ-opioid Receptor-mediated G-protein Activity in the Thalamus Brain Research. Aug, 2011 | Pubmed ID: 21762883 μ-opioid Receptors: Correlation of Agonist Efficacy for Signalling with Ability to Activate Internalization Molecular Pharmacology. Oct, 2010 | Pubmed ID: 20647394 Role of CD38, a Cyclic ADP-ribosylcyclase, in Morphine Antinociception and Tolerance The Journal of Pharmacology and Experimental Therapeutics. Sep, 2010 | Pubmed ID: 20551293 Chronic Constriction Injury Reduces Cannabinoid Receptor 1 Activity in the Rostral Anterior Cingulate Cortex of Mice Brain Research. Jun, 2010 | Pubmed ID: 20380816 Design, Synthesis, and Biological Evaluation of 6alpha- and 6beta-N-heterocyclic Substituted Naltrexamine Derivatives As Mu Opioid Receptor Selective Antagonists Journal of Medicinal Chemistry. Mar, 2009 | Pubmed ID: 19199782 Formation and Function of Ceramide-enriched Membrane Platforms with CD38 During M1-receptor Stimulation in Bovine Coronary Arterial Myocytes American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2008 | Pubmed ID: 18723763 Morphine Tolerance in the Mouse Ileum and Colon The Journal of Pharmacology and Experimental Therapeutics. Nov, 2008 | Pubmed ID: 18682567 Pre-treatment with a PKC or PKA Inhibitor Prevents the Development of Morphine Tolerance but Not Physical Dependence in Mice Brain Research. Jun, 2008 | Pubmed ID: 18501877 Local Production of O2- by NAD(P)H Oxidase in the Sarcoplasmic Reticulum of Coronary Arterial Myocytes: CADPR-mediated Ca2+ Regulation Cellular Signalling. Apr, 2008 | Pubmed ID: 18207366 MGluR5 Antagonists That Block Calcium Mobilization in Vitro Also Reverse (S)-3,5-DHPG-induced Hyperalgesia and Morphine Antinociceptive Tolerance in Vivo Brain Research. Jan, 2008 | Pubmed ID: 18022146 Evidence for an Important Role of Protein Phosphatases in the Mechanism of Morphine Tolerance Brain Research. Jul, 2007 | Pubmed ID: 17582387 Synthesis and Pharmacological Evaluation of Phenylethynyl[1,2,4]methyltriazines As Analogues of 3-methyl-6-(phenylethynyl)pyridine Journal of Medicinal Chemistry. Jul, 2007 | Pubmed ID: 17569516 Decrease in N-methyl-D-aspartic Acid Receptor-NR2B Subunit Levels by Intrathecal Short-hairpin RNA Blocks Group I Metabotropic Glutamate Receptor-mediated Hyperalgesia The Journal of Pharmacology and Experimental Therapeutics. Jul, 2007 | Pubmed ID: 17405869 Determination of the Role of Conventional, Novel and Atypical PKC Isoforms in the Expression of Morphine Tolerance in Mice Pain. Jan, 2007 | Pubmed ID: 16965856 PKC and PKA Inhibitors Reinstate Morphine-induced Behaviors in Morphine Tolerant Mice Pharmacological Research : the Official Journal of the Italian Pharmacological Society. Dec, 2006 | Pubmed ID: 17056270 How Important is Protein Kinase C in Mu-opioid Receptor Desensitization and Morphine Tolerance? Trends in Pharmacological Sciences. Nov, 2006 | Pubmed ID: 17000011 Pharmacological Characterization of Novel Water-soluble Cannabinoids The Journal of Pharmacology and Experimental Therapeutics. Sep, 2006 | Pubmed ID: 16757541 Protein Kinase Inhibitor Peptide (PKI): a Family of Endogenous Neuropeptides That Modulate Neuronal CAMP-dependent Protein Kinase Function Neuropeptides. Feb, 2006 | Pubmed ID: 16442618 Protein Kinase A Activity is Increased in Mouse Lumbar Spinal Cord but Not Brain Following Morphine Antinociceptive Tolerance for 15 Days Pharmacological Research : the Official Journal of the Italian Pharmacological Society. Sep, 2005 | Pubmed ID: 16026714 Chronic Delta9-tetrahydrocannabinol Treatment Produces Antinociceptive Tolerance in Mice Without Altering Protein Kinase A Activity in Mouse Brain and Spinal Cord Biochemical Pharmacology. Jul, 2005 | Pubmed ID: 15913565 Alterations in Brain Protein Kinase A Activity and Reversal of Morphine Tolerance by Two Fragments of Native Protein Kinase A Inhibitor Peptide (PKI) Neuropharmacology. Apr, 2005 | Pubmed ID: 15814100 Task Specificity of Cross-tolerance Between Delta9-tetrahydrocannabinol and Anandamide Analogs in Mice European Journal of Pharmacology. Mar, 2005 | Pubmed ID: 15740725 PKC and PKA Inhibitors Reverse Tolerance to Morphine-induced Hypothermia and Supraspinal Analgesia in Mice European Journal of Pharmacology. May, 2004 | Pubmed ID: 15178359 Effects of MGlu1 and MGlu5 Metabotropic Glutamate Antagonists to Reverse Morphine Tolerance in Mice European Journal of Pharmacology. May, 2004 | Pubmed ID: 15178357 The Expression of a High Level of Morphine Antinociceptive Tolerance in Mice Involves Both PKC and PKA Brain Research. Sep, 2003 | Pubmed ID: 12957370 Prolonged Reversal of Morphine Tolerance with No Reversal of Dependence by Protein Kinase C Inhibitors Brain Research. Dec, 2002 | Pubmed ID: 12468027 En Tricia H. Smith1, Joy Ngwainmbi1, John R. Grider2, William L. Dewey1, Hamid I. Akbarali1 1Pharmacology and Toxicology, Virginia Commonwealth University, 2Physiology and Biophyics, Virginia Commonwealth University Neuroscienze
En Tricia H. Smith1, Joy Ngwainmbi1, John R. Grider2, William L. Dewey1, Hamid I. Akbarali1 1Pharmacology and Toxicology, Virginia Commonwealth University, 2Physiology and Biophyics, Virginia Commonwealth University Neuroscienze