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Single-Cell Mechanobiology Using Fluorescence Micropipette Aspiration

January 12th, 2024
1, 1,2,3, 1, 1, 1,2,3,4, 1, 1,2,3,4
1School of Biomedical Engineering, The University of Sydney, 2Charles Perkins Centre, The University of Sydney, 3Heart Research Institute, 4The University of Sydney Nano Institute (Sydney Nano), The University of Sydney

Summary

The exploration of cellular behavior under mechanical stress is pivotal for advances in cellular mechanics and mechanobiology. We introduce the Fluorescence Micropipette Aspiration (fMPA) technique, a novel method combining controlled mechanical stimulation with comprehensive analysis of intracellular signaling in single cells. This technique investigates new in-depth studies of live-cell mechanobiology.

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