Hand-drawing Silk

Hand-drawing silk is a manual method for separating and combining continuous silk filaments from silkworm cocoons, linking a traditional craft to the biochemistry of silk proteins. In warm water, cocoon fibers soften as sericin, the water-soluble protein that cements fibroin filaments together, becomes hydrated; the loosened filaments can then be gathered and pulled into a cohesive thread. This process provides a direct way to observe how protein composition, hydration, and mechanical alignment influence fiber formation. In biochemistry, hand-drawn silk supports practical study of fibroin structure, sericin removal, biomaterial processing, and the relationship between molecular properties and the strength of natural fibers.

Hand-drawing Silk - Related Videos

Education

JoVE Science Education - Engineering

Electrospinning of Silk Biomaterials

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2023

Silk fibers have been processed and used to create fabrics and threads for centuries. However, the solubilizing of silk fibers, thereby turning it into a versatile pre-polymer solution is a much newer technology. Solubilized silk can be processed in many different ways to create a biocompatible material with controllable mechanical properties. This video introduces the processing of silk from silk worm cocoons, and shows how the silk solution can be used to create a fiber mat via...

Research

JoVE Journal - Bioengineering

Designing Silk-silk Protein Alloy Materials for Biomedical Applications

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Cited by 2 •

2014

Blending is an efficient approach to generate biomaterials with a broad range of properties and combined features. By predicting the molecular interactions between different natural silk proteins, new silk-silk protein alloy platforms with tunable mechanical resiliency, electrical response, optical transparency, chemical processability, biodegradability, or thermal stability can be designed.

Research

JoVE Journal - Bioengineering
Free Sample

Silk Film Culture System for in vitro Analysis and Biomaterial Design

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Cited by 22 •

2012

Silk films are a novel class of biomaterials readily customizable for an array of biomedical applications. The presented silk film culture system is highly adaptable to a variety of in vitro analyses. This system represents a biomaterial design platform offering in vitro optimization before direct translation to in vivo models.

Synthetic Spider Silk Production on a Laboratory Scale

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Cited by 16 •

2012

Despite the outstanding mechanical and biochemical properties of spider silks, this material cannot be harvested in large quantities by conventional means. Here we describe an efficient strategy to spin artificial spider silk fibers, which is an important process for investigators studying spider silk production and their use as next-generation biomaterials.

Manufacture and Drug Delivery Applications of Silk Nanoparticles

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Cited by 49 •

2016

Nanoparticles are emerging as promising drug delivery systems for a broad range of indications. Here, we describe a simple yet powerful method to manufacture silk nanoparticles using reverse engineered Bombyx mori silk. These silk nanoparticles can be readily loaded with a therapeutic payload and subsequently explored for drug delivery applications.

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