Interstitial Positions
Interstitial Positions - Related Videos
03:34
Spatial Measurement of Tumor Interstitial Fluid Pressure: A Method to Measure the Interstitial Fluid Pressure
0 Views •
2023
This video describes a technique of measuring the interstitial fluid pressure within a tumor by perfusion imaging using an image-guided robotic system. Measurements are compared to the intra-tumoral accumulation of liposomes, within a solid tumor.
07:59
The Inverted Heart Model for Interstitial Transudate Collection from the Isolated Rat Heart
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2017
This protocol describes a method to collect cardiac interstitial fluid from the isolated, perfused rat heart. To physically separate interstitial transudate from coronary venous effluent perfusate, the Langendorff perfused heart is inverted, and the transudate (interstitial fluid) formed on the cardiac surface is collected using a soft latex cap.
07:41
Three-dimensional Cell Culture Model for Measuring the Effects of Interstitial Fluid Flow on Tumor Cell Invasion
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Cited by 13 •
2012
Interstitial fluid flow is elevated in solid tumors and can modulate tumor cell invasion. Here we describe a technique to apply interstitial fluid flow to cells embedded in a matrix and then measure its effects on cell invasion. This technique can be easily adapted to study other systems.
09:00
Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors
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Cited by 6 •
2016
The heterogeneous intra-tumoral accumulation of liposomes has been linked to an abnormal tumor microenvironment. Herein methods are presented to measure tumor microcirculation by perfusion imaging and elevated interstitial fluid pressure (IFP) using an image-guided robotic system. Measurements are compared to the intra-tumoral accumulation of liposomes, determined using volumetric micro-CT imaging.
02:29
Microdialysis of Interstitial Fluid from a Mouse Brain to Isolate Extracellular Proteins
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2025
The video demonstrates the process of using a microdialysis probe to collect extracellular proteins from the interstitial fluid (ISF) of a mouse brain. A microdialysis probe, equipped with a high-molecular-weight cut-off semi-permeable membrane, is inserted into the brain of an anesthetized mouse via an implanted guide cannula. The probe, connected to pumps, allows a physiological buffer to perfuse the brain tissue and mix with the ISF. Proteins in the ISF diffuse across the semi-permeable...
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Smaller atoms can enter tetrahedral or octahedral sites, but their presence is not structurally neutral. The surrounding lattice atoms shift away from their ideal positions, producing local strain and changing nearby bonding and symmetry. These distortions explain why interstitial occupancy can modify a solid’s stability and physical behavior rather than merely add particles to an unchanged lattice.
An atom occupying one interstitial site can move to a neighboring site, allowing particles to migrate through the crystal. Repeated site-to-site movement supports atomic diffusion without requiring the entire lattice to reorganize. This mechanism connects the arrangement of available interstitial positions with the movement of atoms through solids and helps explain transport within crystalline materials.
Interstitial occupancy allows a crystal to accommodate additional atoms without matching the exact ratio expected from an ideal chemical formula. Because the added particles occupy available spaces and disturb nearby atoms, the resulting solid can deviate from simple stoichiometry while retaining an organized lattice. This provides a structural basis for understanding nonstoichiometric crystalline compounds.
Occupying interstitial sites can alter hardness, electrical behavior, stability, bonding, symmetry, and local strain. The specific changes arise from the combined effects of added particles and the displacement of surrounding lattice atoms. Consequently, examining site occupancy helps connect microscopic structural changes with measurable differences in the behavior of crystalline materials.
Hydrogen storage is one application in which interstitial positions provide a structural way for a crystal to accommodate additional small atoms. The importance of these sites lies in their ability to host hydrogen while affecting the surrounding lattice and its stability. Studying occupancy and the associated structural changes helps relate crystal structure to storage behavior.
Carbon-containing iron illustrates how a smaller atom can occupy spaces within a metal lattice and influence the host material. The carbon changes local bonding and produces lattice strain, effects that are associated with altered material properties such as hardness. This example connects interstitial chemistry with the behavior of interstitial alloys in materials science.