One-pot Synthesis
One-pot Synthesis - Related Videos
![Microwave-assisted One-pot Synthesis of <em>N</em>-succinimidyl-4-[<sup>18</sup>F]fluorobenzoate ([<sup>18</sup>F]SFB)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F2755.jpg%3Fv%3D2026-09-01%252004%253A39%253A14&w=750&q=75)
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Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)
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Cited by 15 •
2011
A facile, one-pot synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) was developed based on a non-aqueous, three-step radiochemical process. Using microwave heating, the entire procedure can be completed in less than 30 min, or 60 min with further purification by preparative HPLC. The decay-corrected radiochemical yields (RCYs) were 35-5% (n > 30).
09:56
Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
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2019
This protocol demonstrates how to use the Auto-CHO software for hierarchical and programmable one-pot synthesis of oligosaccharides. It also describes the general procedure for RRV determination experiments and one-pot glycosylation of SSEA-4.
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Hydrogel Synthesis
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2023
Source: Amber N. Barron, Ashlea Patterson, and Taylor D. Sparks, Department of Materials Science and Engineering, The University of Utah, Salt Lake City, UT Hydrogels are a versatile class of cross-linked polymers produced through relatively simple procedures and with generally inexpensive materials. They can be formed from solution and involve a polymer backbone formed from monomer reagents, an initiator which makes the polymer reactive and a crosslinking species which binds the polymer chains...
09:42
Solid Phase Synthesis
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2023
Source: Vy M. Dong and Diane Le, Department of Chemistry, University of California, Irvine, CA Merrifield's solid-phase synthesis is a Nobel Prize winning invention where a reactant molecule is bound on a solid support and undergoes successive chemical reactions to form a desired compound. When the molecules are bound to a solid support, excess reagents and byproducts can be removed by washing away the impurities, while the target compound remains bound to the resin. Specifically, we will...
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Synthesis and Decomposition Reactions
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2020
Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes. Synthesis Reactions Synthesis reactions are also called combination reactions. It is a reaction in which two or more substances combine to form a complex substance. Synthesis reactions are generally represented as: A + B → AB or A + B → C. The formation of nitrogen dioxide is a synthesis...
FAQs
One-pot synthesis succeeds when the product of one reaction can proceed directly into the next transformation under compatible conditions. Chemists coordinate sequential reagent additions or adjust temperature, solvent, pH, or atmosphere to guide each stage. This compatibility determines whether a multistep sequence can remain in one vessel without disrupting later reactions.
Sequential reagent addition controls which transformation occurs at each stage. Rather than introducing all reactants at once, the chemist adds a new reagent after an earlier step has progressed, then changes conditions when needed. This staged control helps connect several reactions while avoiding intermediate isolation and purification.
Compared with a workflow that isolates each intermediate, one-pot synthesis removes handling and purification stages between reactions. That reduction can shorten the sequence, lower solvent and energy consumption, and limit material use associated with processing intermediates. The approach therefore targets improved overall efficiency while retaining a multistep route to a complex molecule.
A typical workflow starts with simpler starting materials in a single vessel, followed by sequential reagent additions for the planned transformations. The chemist may then change temperature, solvent, pH, or atmosphere before the next step. Because intermediates remain in place, the sequence proceeds without their isolation or purification.
Key operating variables are reagent timing and the reaction environment. Temperature, solvent, pH, and atmosphere can each be controlled or changed to make conditions suitable for the next transformation. Managing these variables is important because the same vessel must support successive steps instead of isolating an intermediate between reactions.
Chemists apply one-pot synthesis to routes that build complex molecules from simpler starting materials with fewer processing steps. Relevant targets include pharmaceuticals, natural products, polymers, and other complex molecules. In these settings, reduced intermediate handling can support shorter workflows, lower resource use, and potentially better overall yield and safety.