Hamster Model
Hamster Model - Related Videos
11:36
Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
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Cited by 40 •
2012
Optimization of the experimental hamster model for cutaneous leishmaniasis by intradermal injection of Leishmania promastigotes at the dorsal skin. This approach is useful during inoculation, follow-up, characterization of lesions, application of treatments and obtaining of clinical samples. Locomotion, search for food and water, play and social activities are preserved.
06:12
Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex
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Cited by 24 •
2018
Pronuclear (PN) injection of the clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein-9 nuclease (CRISPR/Cas9) system is a highly efficient method for producing genetically engineered golden Syrian hamsters. Herein, we describe the detailed PN injection protocol for the production of gene knockout hamsters with the CRISPR/Cas9 system.
13:36
Collection and Cryopreservation of Hamster Oocytes and Mouse Embryos
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Cited by 9 •
2009
In this video-article we present a step-by-step demonstration on how to collect and cryopreserve hamster oocytes with high post-thaw survival rates. The same procedure can also be applied to successfully freeze and thaw mouse embryos at different stages of preimplantation development.
02:28
A Technique to Purify Monoclonal Antibodies Produced by Chinese Hamster Ovary Cells
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2025
This video demonstrates an assay for purifying monoclonal antibodies from cell culture fluid harvested from Chinese Hamster Ovarian cells. It employs a porous glass resin with immobilized protein A, which binds to the Fc region of the antibodies in the sample, effectively separating them from contaminants. The use of a low-pH elution buffer weakens the interaction, facilitating the retrieval of purified antibodies.
10:23
Measuring In Vivo Changes in Extracellular Neurotransmitters During Naturally Rewarding Behaviors in Female Syrian Hamsters
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Cited by 3 •
2017
This paper details the use of fixed-potential amperometric recordings using carbon fiber electrodes and enzymatic biosensor technology to measure the release of dopamine and glutamate with high temporal resolution during natural rewarding behavior in the female hamster.
FAQs
Researchers follow pathogen replication and tissue damage over time rather than examining immune activity in isolation. Comparing these changes with clinical signs can show whether increasing replication, stronger tissue injury, or both coincide with more severe disease. This time-based view helps relate cellular and molecular events to outcomes observed across the whole organism.
Innate defenses provide an early view of how the organism responds to infection, while adaptive responses reveal later antibody production and other targeted immune activity. Monitoring both phases helps researchers distinguish immediate protection from responses that develop over time. Their combined patterns can clarify how immune activity relates to pathogen control, tissue damage, and recovery.
Antibody production provides evidence of an adaptive immune response and helps researchers assess whether exposure produces protective immunity. When antibody findings are considered alongside pathogen replication, tissue damage, and clinical signs, they offer a broader interpretation of immune effectiveness. This relationship is especially relevant when evaluating whether an intervention changes disease outcomes rather than only immune measurements.
A hamster study can examine transmission alongside disease development and immune responses, allowing researchers to consider whether protective immunity affects the spread of infection. Tracking these outcomes together is more informative than measuring disease severity alone. The resulting evidence can support assessment of infection-control strategies and help connect individual immune responses with broader transmission-related outcomes.
A typical study introduces either a pathogen or an experimental antigen, then monitors relevant changes over time. Researchers may assess pathogen replication, tissue damage, innate defenses, antibody production, adaptive immune responses, clinical signs, transmission, or protective immunity, depending on the research question. Comparing these measurements helps determine how infection or immune intervention affects disease-related outcomes.
These models are useful when researchers need to evaluate an intervention in the context of an intact organism. Vaccine studies can focus on protective immunity, while therapeutic studies can examine changes in pathogen replication, tissue damage, immune responses, or clinical signs. The approach also supports investigation of infection-control strategies by linking intervention effects with transmission and disease severity.