Murine Muscle Training
Murine Muscle Training - Related Videos
08:24
A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation
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Cited by 18 •
2012
A murine model of neuromuscular electrical stimulation (NMES), a safe and inexpensive clinical modality, to the anterior compartment muscles is described. This model has the advantage of modifying a readily available clinical device for the purpose of eliciting targeted and specific muscle contractions in mice.
08:24
Isolation of Murine Coronary Vascular Smooth Muscle Cells
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Cited by 11 •
2016
The purpose of this protocol is to demonstrate the isolation and culture techniques of murine primary vascular smooth muscle cells (VSMCs) from the coronary circulation. Once VSMCs have been isolated, they can be used for many standard culture techniques.
04:16
Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide
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2026
Respiratory muscle weakness is highly prevalent in patients weaning from mechanical ventilation. Resistive inspiratory muscle training (IMT) can improve inspiratory strength and potentially weaning outcomes. This protocol provides a structured approach to offer IMT to selected patients based on the best available knowledge, facilitating its wider application in critical care.
03:40
Hindlimb Skeletal Muscle Extraction: A Procedure to Excise Hindlimb Skeletal Muscles from Murine Model
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2023
In this video, we describe the procedure to excise hindlimb skeletal muscles from a mouse model. The excised muscles can be stored at lower temperatures until further downstream...
12:59
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
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Cited by 6 •
2017
The effect of short-term resistance training on elderly people was investigated through the simultaneous use of several methods. Compared to a control group, many improvements were seen, including on muscle aerobic capacity, glucose tolerance, strength, power, and muscle quality (i.e., protein involved in cell signaling and muscle fiber type composition).
FAQs
These variables determine the pattern of repeated contractile activity imposed on skeletal muscle. Standardizing them allows researchers to distinguish adaptations associated with different training conditions and to compare results across experiments. Defined progression is especially useful when studying changes in performance, energy use, tissue remodeling, or responses to muscle disease and recovery.
Mechanical and metabolic signals provide the main links between contractile activity and muscle remodeling. They can regulate muscle fiber function, energy use, vascular responses, and broader tissue changes. Examining these responses helps researchers connect cellular mechanisms with measurable functional outcomes, creating a mechanistic basis for studying muscle health and disease.
Both approaches provide repeated contractile activity, but they represent different ways of applying the exercise stimulus. Voluntary protocols allow activity to occur through the animal’s own exercise behavior, whereas externally imposed protocols deliver a defined training challenge. This distinction helps investigators select conditions suited to questions about adaptation, performance, or disease-related muscle changes.
Studies can assess how training relates to muscle adaptation, performance, energy use, vascular responses, and tissue remodeling. These outcomes help show whether changes occur mainly at the level of muscle function or reflect broader biological processes. Linking such measurements provides a way to relate cellular responses to functional consequences relevant to medicine.
A study begins by selecting a voluntary or externally imposed exercise approach and defining the duration, intensity, and progression of training. Researchers then apply repeated contractile activity under those controlled conditions and evaluate relevant muscle or functional outcomes. This structured workflow supports comparisons between training responses, disease states, recovery patterns, and potential interventions.
The approach is useful for examining muscle wasting, injury recovery, aging, obesity, and neuromuscular disorders. It also supports evaluation of potential therapies and rehabilitation strategies. Because training conditions can be standardized and measured, researchers can investigate how disease or treatment influences muscle adaptation and connect biological mechanisms with outcomes related to human health.