Gastric Bypass Rat Model
Gastric Bypass Rat Model - Related Videos
07:37
Roux-en-Y Gastric Bypass Operation in Rats
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Cited by 45 •
2012
Numerous studies using gastric bypass rat models have been recently conducted to uncover the underlying physiological mechanisms of Roux-en-Y gastric bypass operations. This article aims to demonstrate and discuss the technical and experimental details of our published gastric bypass rat model to understand advantages and limitations of this experimental tool.
05:18
Roux-en-Y Gastric Bypass Procedure: A Bariatric Surgical Procedure for Gastric Resectioning in Murine Model
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2025
This video describes a bariatric surgery-Roux-en-Y procedure. This involves the cutting of the jejunum- the middle portion of the intestine- to generate two intestinal limbs. The biliary limb is attached to the existing intestinal loop and the alimentary limb is attached to the stomach, creating a gastric bypass. The gastric bypass created here helps to decrease the nutrient uptake and efficiently reduces body weight.
08:16
One-anastomosis Gastric Bypass (OAGB) in Rats
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Cited by 5 •
2018
This protocol is for the performance of one-anastomosis gastric bypass (OAGB) on rat. The operator performs a long and tubular-stapled gastric pouch followed by hand-sewn anastomosis. For this model, the operator reproduces the same ratio between biliopancreatic and common limb in humans; therefore, the biliopancreatic limb measures 35 cm.
11:58
A Protocol for Roux-en-Y Gastric Bypass in Rats using Linear Staplers
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Cited by 1 •
2021
Roux-en-Y gastric bypass (RYGB) is performed to treat obesity and diabetes. However, the mechanisms underlying RYGB's efficacy are not fully understood, and studies are limited by technical difficulty leading to high mortality in animal models. This article provides instructions on how to perform RYGB in rats with high success rates.
08:08
Cardiopulmonary Bypass in a Mouse Model: A Novel Approach
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Cited by 9 •
2017
This paper describes how to perform cardiopulmonary bypass in mice. This novel model will facilitate the investigation of the molecular mechanisms involved in organ damage.
FAQs
The model changes several linked variables: functional stomach volume, nutrient delivery, nutrient absorption, and gut hormone signaling. Investigators consider these factors together because altered gastrointestinal physiology may influence appetite, glucose regulation, insulin sensitivity, and body weight. Tracking the full set helps distinguish effects associated with changed gut anatomy from outcomes explained only by reduced food intake.
Body-weight change alone cannot capture the full metabolic response to gastric bypass. Measurements of glucose regulation and insulin sensitivity indicate whether the intervention affects metabolic control, while appetite and nutrient absorption provide additional physiological context. This broader assessment helps researchers investigate why gastric bypass can produce benefits that extend beyond limiting food intake.
Redirecting nutrients through a changed gastrointestinal route modifies when and where nutrients reach the digestive system. The overview identifies this altered delivery as a factor that changes gut hormone signaling, appetite, glucose regulation, and insulin sensitivity. Studying these connected responses allows researchers to examine how gastrointestinal signals may accompany the metabolic effects of bypass surgery.
Interpretation must account for both reduced functional stomach volume and the bypassed portion of the stomach and small intestine. These changes affect the route of food, nutrient delivery, and nutrient absorption. Consequently, an observed metabolic outcome may reflect several coordinated gastrointestinal alterations rather than a single isolated mechanism.
Studies can use the model to examine changes in weight loss, glucose regulation, insulin sensitivity, appetite, nutrient absorption, and gastrointestinal physiology. Evaluating these outcomes together provides a wider picture of how altered gut anatomy affects metabolic function. The resulting data can help clarify relationships among food intake, digestive processes, and metabolic improvement.
In medicine, the model supports investigation of mechanisms relevant to obesity, type 2 diabetes, and related metabolic disorders. Its value lies in connecting surgical changes in gastrointestinal anatomy with changes in appetite, glucose control, insulin sensitivity, and body weight. This research context can help explain the metabolic effects associated with bariatric surgery.