Nasal Silica Exposure
Nasal Silica Exposure - Related Videos
09:50
Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
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Cited by 41 •
2015
The aim of this protocol is to expose human organotypic 3D bronchial and nasal tissue models to mainstream cigarette smoke (CS) at the air-liquid interface. The impact of CS on the tissues is then investigated using a cytochrome P450 activity assay, a cilia beating measurement, and a systems biology approach.
05:03
Establishing a Silicosis Rat Model via Exposure of Whole-Body to Respirable Silica
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Cited by 2 •
2022
This study describes a technique to establish a silicosis rat model with the inhalation of silica through the whole body in an inhalation chamber. The rats with silicosis could closely mimic the pathological process of human silicosis in an easy, cost-effective manner with good repeatability.
07:51
Fabrication of Silica Ultra High Quality Factor Microresonators
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Cited by 22 •
2012
We describe the use of a carbon dioxide laser reflow technique to fabricate silica resonant cavities, including free-standing microspheres and on-chip microtoroids. The reflow method removes surface imperfections, allowing long photon lifetimes within both devices. The resulting devices have ultra high quality factors, enabling applications ranging from telecommunications to biodetection.
09:11
Porosimetry of a Silica Alumina Powder
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2023
Source: Kerry M. Dooley and Michael G. Benton, Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA Surface area and pore size distribution are attributes used by adsorbent and catalyst manufacturers and users to ensure quality control and to determine when products are at the end of their useful lives. The surface area of a porous solid is directly related to its adsorption capacity or catalytic activity. The pore size distribution of an adsorbent or catalyst is...
10:27
The Evolution of Silica Nanoparticle-polyester Coatings on Surfaces Exposed to Sunlight
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Cited by 12 •
2016
Two types of surfaces, polyester-coated steel and polyester coated with a layer of silica nanoparticles, were studied. Both surfaces were exposed to sunlight, which was found to cause substantial changes in the chemistry and nanoscale topography of the surface.
FAQs
Particle size influences where silica deposits and how broadly exposure may affect the respiratory tract. Smaller respirable particles can travel deeper into the airways, while particles contacting the nasal passages may affect the mucosa locally. Considering particle size helps distinguish upper-airway irritation from hazards that may extend toward deeper respiratory tissues.
Dose and duration help determine the intensity and persistence of tissue stress. Greater or repeated exposure can increase the opportunity for epithelial damage, oxidative stress, and inflammatory signaling. These variables are therefore important when interpreting symptoms, comparing occupational or environmental exposures, and estimating whether observed effects may reflect continuing respiratory risk.
Contact with silica particles can damage the nasal epithelium, the cell layer lining the passages, and activate oxidative stress and inflammatory signaling. These responses provide a mechanistic link between particle deposition and local irritation. Studying them helps explain how exposure may produce symptoms and how upper-airway effects fit within broader inhalation-related injury.
Nasal deposition can offer information about the broader inhalation conditions experienced by an exposed person. Although the nasal passages are an accessible site of contact, smaller respirable particles may move farther into the airways, where persistent exposure can promote fibrosis and impaired lung function. Upper-airway observations therefore add context to respiratory risk assessment.
Assessment should account for the particle characteristics described in the exposure, particularly size, along with dose and duration. Clinicians and occupational-health professionals can then relate these factors to local nasal effects, possible deeper airway involvement, and reported symptoms. This structured consideration supports risk assessment rather than relying on symptoms alone.
Occupational-health surveillance can use exposure information and symptom evaluation to monitor people who may encounter silica particles. The purpose is to identify patterns of nasal or respiratory effects, support continuing risk assessment, and recognize when exposure-control strategies need attention. Surveillance also contributes to research linking upper-airway deposition with broader inhalation hazards.
Exposure-control strategies address the conditions that determine contact with silica, including particle burden and the duration of exposure. In medicine and occupational health, evaluating these strategies helps determine whether workers are receiving less exposure and whether associated symptoms or respiratory concerns change over time. The findings guide protective practices and ongoing surveillance.