Intracranial Vessels
Intracranial Vessels - Related Videos
01:55
Intracranial Injection of Gut-Derived Microbial Metabolites in a Mouse Model
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2025
Source: Liou, C. et al. Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice. J. Vis. Exp. (2022).This video demonstrates the intracranial injection of short-chain fatty acids (SCFAs) in a freely moving mouse to study their effects on brain-mediated behavior. An injector cannula is inserted into a guide cannula implanted in the mouse brain. After recovery, the mouse acclimates in a novel cage. SCFAs are then administered, and locomotor behavior is recorded.
08:47
Intracranial Injection of Adeno-associated Viral Vectors
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Cited by 56 •
2010
Here we present the intracranial injection of AAV vectors for fluorescent labeling of neurons and glia in the visual cortex.
13:10
Stability of Floating Vessels
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2023
Source: Alexander S Rattner and Kevin Rao Li Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA The objective of this experiment is to demonstrate the phenomenon of stability of floating vessels - the ability to self-right when rolled over to the side by some external force. Careful design of hull shapes and internal mass distribution enables seagoing vessels to be stable with low drafts (submerged depth of hull), improving vessel...
09:04
Epidural Intracranial Pressure Measurement in Rats Using a Fiber-optic Pressure Transducer
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Cited by 30 •
2012
A novel technique to record the pressures within the skull is described. The minimally invasive method uses a fibre-optic pressure sensing system to accurately measure intracranial pressure (ICP) in anaesthetized rats without causing significant brain trauma. The technique may be used in a wide range of experimental models.
12:09
A Novel High-resolution In vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics
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Cited by 14 •
2013
We describe a novel in vivo imaging technique that couples fluorescent chimeric mice with intracranial windows and high-resolution 2-photon microscopy. This imaging platform aids studies of dynamic changes in brain tissue and microvasculature, at a single-cell level, following pathological insults and is adaptable to assess intracranial drug delivery and distribution.
FAQs
Branching vascular networks adjust cerebral blood flow by changing vascular resistance. These changes control how readily blood moves through different parts of the circulation, helping match delivery with the brain’s metabolic requirements. Studying this regulation is important because disrupted resistance control can alter oxygen and nutrient supply, contributing to neurological dysfunction.
Neurovascular coupling links neural activity to local changes in blood flow. When neuronal demand changes, associated vascular responses help modify circulation in the relevant brain region. This relationship allows physiological measurements of blood flow to provide indirect information about brain function and helps researchers investigate how vascular responses become altered in neurological disease.
Specialized capillary walls help form the blood-brain barrier, a selective interface between circulating blood and brain tissue. This barrier is a key functional property of the cerebral microvasculature rather than simply a feature of large vessels. Examining it helps neuroscience researchers study how vascular changes may affect the brain’s protected environment in disease.
The branching arrangement distributes blood across the brain through progressively smaller vascular segments, including arteries, arterioles, capillaries, venules, and veins. This organization supports both delivery and removal functions while providing multiple points at which blood flow can be regulated. Its structure is therefore relevant when interpreting regional vascular measurements or disease-related alterations.
Researchers can combine vascular imaging with physiological measurements to examine vessel structure and blood-flow behavior. Imaging helps assess the vascular network, while physiological measurements characterize circulation and its responses. Together, these approaches can reveal altered blood flow, support investigations of neurovascular coupling, and help evaluate whether an experimental therapy changes vascular function.
Vascular studies provide context for conditions such as stroke, aneurysms, tumors, and neurodegenerative disease. Researchers examine whether changes in vessel structure, blood flow, or barrier-related function accompany neurological dysfunction. The resulting measurements can clarify vascular contributions to disease mechanisms and support evaluation of potential therapies aimed at improving or preserving brain function.