Payload Delivery
Payload Delivery - Related Videos
09:02
Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model
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Cited by 3 •
2024
The blood-brain barrier is a significant hurdle in the delivery of therapies for glioblastoma, a disease for which there is no cure. Here, we report an in vivo image-guided iron oxide therapeutic nano platform that can bypass this physiological barrier by virtue of size and accumulate in the tumor.
13:34
Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish
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Cited by 13 •
2019
Drug targeting to central nervous system tumors is a major challenge. Here we describe a protocol to produce an in vitro mimic of the blood-brain tumor-barrier using murine and/or human cells and discuss their relevance for the predictability of central nervous system tumor targeting in vivo.
14:10
Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
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Cited by 15 •
2010
Insonation of microbubbles is a promising strategy for tumor ablation at reduced time-averaged acoustic powers, as well as for the targeted delivery of therapeutics. The purpose of the present study is to develop low duty cycle ultrasound pulsing strategies and nanocarriers to maximize non-thermal microvascular ablation and payload delivery to subcutaneous C6 gliomas.
09:23
Surgical Technique for Spinal Cord Delivery of Therapies: Demonstration of Procedure in Gottingen Minipigs
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Cited by 24 •
2012
Short visual description of the surgical technique and device used for the delivery of (gene and cell) therapies into the spinal cord. The technique is demonstrated in the animal but is entirely translatable and currently being used for human application.
06:30
Intraductal Delivery to the Rabbit Mammary Gland
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Cited by 9 •
2017
Here, we describe a technique for the localized delivery of reagents to the rabbit mammary gland via an intraductal injection. In addition, we describe a protocol for visualization and the confirmation of delivery by high-resolution ultrasound imaging of contrast agents.
FAQs
Encapsulation places the cargo within a carrier, whereas chemical linkage attaches it to that carrier. These designs can protect a drug, nucleic acid, protein, or imaging agent from conditions that may reduce activity and can determine how the cargo becomes available at its destination. Selecting between them connects payload properties with the intended stability and release behavior.
Release can be governed by local pH, enzymes, or an externally applied stimulus. A carrier designed to respond to one of these conditions can keep the payload associated with the system until the relevant trigger appears, then promote cargo availability. This matters when delivery must be concentrated at a desired location rather than released indiscriminately.
Effective performance depends on more than carrying capacity. The system must preserve payload activity, support appropriate tissue or cellular uptake, and release the cargo under suitable conditions. Improving one feature may not ensure success if another is inadequate, so bioengineered carriers are evaluated as coordinated systems linking stability, localization, uptake, and controlled release.
Directing a payload toward a desired tissue or cell can increase the amount of useful cargo where it is needed while limiting exposure elsewhere. This balance is important because delivery performance is not measured only by whether cargo reaches a biological system. It also depends on localization, retained activity, and release control, which together influence therapeutic or diagnostic value.
A practical design workflow begins by identifying the cargo and its intended location, then selecting a carrier strategy that can encapsulate or chemically link the payload. Researchers next consider whether the design preserves activity, supports tissue or cellular uptake, and responds to the chosen release condition. These criteria guide refinement before applying the system to a bioengineering problem.
Payload delivery supports drug development, gene therapy, diagnostics, and regenerative medicine. The cargo may be a drug, nucleic acid, protein, or imaging agent, and carrier design helps determine whether it remains active, reaches the desired location, and releases appropriately. Across these areas, the intended outcome is greater precision, improved local efficacy, reduced unintended exposure, or better therapeutic results.