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Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
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Bioengineering
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JoVE Journal Bioengineering
Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

DOI:
10.3791/2145-v

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14:10 min

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December 15, 2010

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,
1Department of Biomedical Engineering,University of Virginia , 2Neurological Surgery ,University of Virginia

Chapters

  • 00:05Title
  • 02:02Introduction
  • 02:37Preparation of the Animal Model
  • 02:59Nanoparticle Fabrication
  • 06:07In Vivo Ultrasound to Perform Targeted Drug Delivery
  • 07:12Nanoparticle Biodistribution
  • 10:44Tumor Growth Rate
  • 11:22Tumor Processing and Analysis
  • 12:21Representative Results
  • 13:24Conclusion

Summary

Automatic Translation

Automatic Translation

Insonation of microbubbles is a promising strategy for tumor ablation at reduced time-averaged acoustic powers, as well as for the targeted delivery of therapeutics. The purpose of the present study is to develop low duty cycle ultrasound pulsing strategies and nanocarriers to maximize non-thermal microvascular ablation and payload delivery to subcutaneous C6 gliomas.

Tags

Contrast UltrasoundTargeted TreatmentGliomasMiceDrug-bearing NanoparticlesMicrovascular AblationMinimally-invasiveContrast Agent MicrobubbleUltrasound Pulsing ParametersMalignant Brain TumorsDrug DeliveryComposite Delivery AgentsPoly(lactide-co-glycolide) NanoparticlesAlbumin Shelled MicrobubblesSubcutaneous C6 GliomasNanoparticle DeliveryMicrobubble-nanoparticle Composite Agents (MNCAs)Cancer ApplicationsTumor MicrocirculationTumor HypoxiaApoptosisNon-thermal Cavitation-induced Microvascular Ablation

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