Journal
/
Medicine
/
Surgical Technique for Spinal Cord Delivery of Therapies: Demonstration of Procedure in Gottingen Minipigs
JoVE Journal
Medicine
A subscription to JoVE is required to view this content.  Sign in or start your free trial.
JoVE Journal Medicine
Surgical Technique for Spinal Cord Delivery of Therapies: Demonstration of Procedure in Gottingen Minipigs

Surgical Technique for Spinal Cord Delivery of Therapies: Demonstration of Procedure in Gottingen Minipigs

DOI:
10.3791/4371-v

•

09:23 min

•

December 07, 2012

•

, , , , , , , , , ,
1Department of Neurosurgery,Emory University, 2Department of Neuroscience,Medical University of South Carolina, 3Division of Neurosurgery,University of Alabama, Birmingham, 4Department of Biomedical Engineering,Georgia Institute of Technology , 5Department of Biomedical Engineering,Emory University

Chapters

  • 00:05Title
  • 01:55Animal Use, Anesthesia, and Positioning
  • 03:26Laminectomy, Placement of Spinal Derrick, and Assembling a Floating Cannula
  • 05:17Opening the Dura and Spinal Cord Injections, and Closure
  • 08:16Representative Spinal Cord Delivery Results
  • 09:00Conclusion

Summary

Automatic Translation

Automatic Translation

Short visual description of the surgical technique and device used for the delivery of (gene and cell) therapies into the spinal cord. The technique is demonstrated in the animal but is entirely translatable and currently being used for human application.

Tags

Surgical TechniqueSpinal Cord DeliveryTherapiesDemonstration Of ProcedureGottingen MinipigsGene TherapiesCell TherapiesStem Cell TransplantationFDA-approvedALS PatientsProof-of-principle DataRodent ModelsLarge AnimalsSurgical ProcedureDevice SafetyHuman UseSwine ModelProcedural Safety

Article

Embed

ADD TO PLAYLIST

Usage Statistics

Related Videos

check_url/4371?article_type=v

Acute and Chronic Tactile Sensory Testing after Spinal Cord Injury in Rats
check_url/4371?article_type=v

A Contusion Model of Severe Spinal Cord Injury in Rats
check_url/4371?article_type=v

Controlled Cortical Impact Model for Traumatic Brain Injury
check_url/4371?article_type=v

A Radio-telemetric System to Monitor Cardiovascular Function in Rats with Spinal Cord Transection and Embryonic Neural Stem Cell Grafts
check_url/4371?article_type=v

Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice
check_url/4371?article_type=v

Calibrated Forceps Model of Spinal Cord Compression Injury
check_url/4371?article_type=v

Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury
check_url/4371?article_type=v

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
check_url/4371?article_type=v

A Neonatal Mouse Spinal Cord Compression Injury Model
check_url/4371?article_type=v

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Read Article