Estrogen Feedback Mechanism
Estrogen Feedback Mechanism - Related Videos
03:52
Estrogen Receptor-Reporter Activity Assay to Screen Phytoestrogen Estrogenic Activity
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2025
This video describes a cell-based reporter assay to determine the estrogenic activity of plant-derived compounds. A compound with estrogen-like activity mimics its binding to estrogen receptors and drives downstream reporter enzyme gene transcription. The reporter enzyme generates bioluminescence in a reaction, indicating the estrogenic activity of the compound.
14:13
Detecting Estrogenic Ligands in Personal Care Products using a Yeast Estrogen Screen Optimized for the Undergraduate Teaching Laboratory
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Cited by 1 •
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This article presents an optimized yeast estrogen screen for quantifying ligands in Personal Care Products (PCPs) that bind estrogen receptors alpha (ERα) and/or beta (ERβ). The method incorporates two colorimetric substrate options, a six-day refrigerated incubation for use in undergraduate courses, and statistical tools for data analysis.
08:48
An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
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Cited by 11 •
2015
We developed an in vitro model of dormancy in the bone marrow for estrogen-sensitive breast cancer cells. The goal of this protocol is to demonstrate use of the model for the study of the molecular and cellular biology of dormancy and for generation of hypotheses for subsequent testing in vivo.
00:46
Feedback Inhibition
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2019
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell! Since enzymes help control the rate of reactions, their activity is regulated so that appropriate amounts of starting materials, intermediate metabolites, and products are maintained in the cell. Excessive build-up or depletion of...
16:24
Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
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Cited by 9 •
2014
Molecular signaling through both estrogen and microRNAs are critical in breast cancer development and growth. Estrogen activates the estrogen receptors, which are transcription factors. Many transcription factors can regulate the expression of microRNAs, and estrogen-regulated microRNAs can be profiled using different large-scale techniques.
FAQs
The response depends on both estrogen concentration and its persistence. At low to moderate concentrations, estrogen generally suppresses hypothalamic GnRH secretion, which limits pituitary release of FSH and LH. When estrogen remains high, the relationship reverses and produces positive feedback associated with the mid-cycle LH surge, linking endocrine conditions to changing reproductive events.
The hypothalamus and pituitary form the central signaling pathway affected by estrogen. Estrogen modifies GnRH activity in the hypothalamus, while changes in GnRH influence pituitary secretion of FSH and LH. This arrangement connects ovarian hormonal conditions with gonadotropin output, allowing endocrine signals to coordinate follicle development and the events leading toward ovulation.
Negative feedback helps limit FSH and LH release during periods of low to moderate estrogen, supporting controlled reproductive-cycle regulation. Sustained high estrogen instead generates positive feedback and the mid-cycle LH surge. That shift is important because it connects a change in ovarian hormone signaling with ovulation and the timing of other cycle events.
Cycle timing reflects changing interactions among estrogen, the hypothalamus, and the pituitary rather than estrogen acting in isolation. Earlier low to moderate concentrations generally restrain GnRH, FSH, and LH output, whereas sustained high concentrations support the mid-cycle LH surge. This changing feedback pattern helps coordinate follicle development, ovulation, and menstrual-cycle progression.
The mechanism provides a framework for relating estrogen-dependent signaling to follicle development, ovulation, and menstrual-cycle timing. Because these processes are central to reproductive function, researchers can use the framework when studying fertility and reproductive disorders. It also supplies biological context for examining hormonal therapies that affect reproductive regulation.
Studying this signaling system helps explain how endocrine communication integrates ovarian activity with control centers in the brain and pituitary gland. It can clarify how feedback changes influence gonadotropin release and reproductive events, while also connecting basic biology with fertility, reproductive disorders, hormonal therapies, and the regulation of menstrual-cycle timing.