Intra-arterial Administration
Intra-arterial Administration - Related Videos
07:00
Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis
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Cited by 43 •
2016
This manuscript provides the detailed procedure of intra-iliac artery (IIA) injection, a technique to deliver cancer cells specifically to hind limb tissues including bones to establish experimental bone metastases. Although initially established with breast tumor models, this protocol can be easily extended to other cancer types.
13:32
Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices
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Cited by 29 •
2014
Hypoxic pulmonary vasoconstriction (HPV) is an important physiological phenomenon by which at alveolar hypoxia lung perfusion is matched to ventilation. The major vascular segment contributing to HPV is the intra-acinar artery. Here, we describe our protocol for the analysis of HPV of murine pulmonary vessels with diameters of 20-100 μm.
05:10
Intrarenal Drug Delivery in Rats: A Method to Deliver Therapeutic Drugs in Rat Kidney via Intra-arterial Injection
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2023
In this video, we demonstrate intra-renal drug administration in rats via the renal artery. This method is beneficial in improving drug targeting, drug potency, and minimizing systemic toxicity.
15:05
Compound Administration I
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2015
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN As many research protocols require that a substance be injected into an animal, the route of delivery and the amount of the substance must be accurately determined. There are several routes of administration available in the mouse and rat. Which route to use is determined by several factors of the substance to be injected: the pH of the solution, the volume required for the desired dosage, and...
09:38
Femoral Arterial and Venous Catheterization for Blood Sampling, Drug Administration and Conscious Blood Pressure and Heart Rate Measurements
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Cited by 53 •
2012
Chronic catheterization of blood vessels in the rat is often required for administration of substances, obtain blood sample over a period of time or for direct conscious blood pressure measurements. Femoral arterial catheterization of the rat and corresponding measurements of blood pressure in the conscious animal will be demonstrated.
FAQs
Accurate catheter placement determines whether the agent reaches the intended vessel and tissue. Blood flow then affects how the substance distributes after controlled injection, while the dosage influences the amount delivered locally. Because these factors interact, clinicians must monitor the procedure carefully to support the desired effect and reduce vascular or procedural risks.
Direct injection into a selected artery releases the agent near its intended tissue instead of distributing it initially throughout the body. This approach can create higher exposure in the regional circulation, which supports localized treatment. The resulting benefit depends on catheter position, blood flow, and dosage rather than on the injection route alone.
The same vascular access principle can support different objectives. Contrast agents help perform vascular imaging, whereas medications may provide regional chemotherapy or thrombolysis. Embolization uses an administered substance to address a vessel-based treatment goal. Thus, the agent and clinical purpose determine the intended outcome, while catheter accuracy and monitoring remain important across uses.
A clinician first guides a catheter through the arterial system toward a selected vessel. After positioning it near the intended tissue, the agent is injected in a controlled manner. The procedure then requires monitoring of the administration and its effects, because accurate placement, dosage, blood flow, and vascular conditions influence both effectiveness and safety.
Clinicians may choose this technique when treatment or imaging should focus on a particular vascular region. Supported applications include angiography with contrast agents, regional chemotherapy, thrombolysis, and embolization. Its value is greatest when localized delivery offers a meaningful procedural or therapeutic purpose, while the potential for vascular and other procedural risks requires careful management.
With contrast agents, the technique can support angiography and vascular imaging by placing the agent within the relevant arterial circulation. With therapeutic substances, it can deliver treatment near selected tissue, including regional chemotherapy or thrombolysis. The outcome depends on how well catheter placement, injection control, dosage, and blood flow match the clinical objective.