Fetal Mouse Physiology
Fetal Mouse Physiology - Related Videos
09:20
A Mouse Fetal Skin Model of Scarless Wound Repair
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Cited by 24 •
2015
During mammalian development, early gestational skin wounds heal without a scar. Here we detail a reliable and reproducible model of fetal scarless wound healing in the cutaneous dorsum of E16.5 (scarless) and E18.5 (scarring) mouse embryos.
10:12
A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model
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Cited by 8 •
2012
We developed a novel surgical approach for intratracheal administration of bioactive agents into the mouse fetus. The delivery route is more efficient in targeting the fetal mouse lungs than the commonly used intra-amniotic injection. This procedure has to date not been described in a mouse model.
03:56
Modeling Transuterine Fetal Tracheal Occlusion in Murine Model: A Surgical Procedure for Ligation of the Fetal Trachea Within a Pregnant Mouse
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2025
This video demonstrates the transuterine tracheal occlusion procedure of a mouse fetus in a pregnant mouse. This model can be used to study the impact of occluded trachea on lung development.
08:04
Murine Fetal Echocardiography
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Cited by 7 •
2013
Fetal and perinatal death is a common feature when studying genetic alterations affecting cardiac development. High-frequency ultrasound imaging has improved 2-D resolution and can provide excellent information on early cardiac development and is an ideal method to detect the impact on cardiac structure and function prior to death.
09:47
Using Ex Vivo Upright Droplet Cultures of Whole Fetal Organs to Study Developmental Processes during Mouse Organogenesis
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Cited by 13 •
2015
The ex vivo upright droplet culture is an alternative to current in vitro and in vivo experimental techniques. This protocol is easy to perform and requires smaller amounts of reagent, while permitting the ability to manipulate and study fetal vascularization, morphogenesis, and organogenesis.
FAQs
Maternal–placental exchange supplies the developing fetus with oxygen and nutrients while supporting removal of fetal waste. These transfers create the conditions required for continued growth and organ maturation before birth. Changes affecting exchange can therefore influence physiological development, making this interface important when investigating prenatal exposures, developmental disorders, or abnormal fetal outcomes.
Fetal circulation distributes oxygen and nutrients obtained through the placenta and helps direct waste products toward maternal elimination. Its function must remain coordinated with progressive organ development, particularly as the heart and other systems mature. Studying these relationships allows researchers to connect altered circulation with broader physiological consequences during prenatal development.
Physiological stability depends on several systems developing together rather than maturing independently. Progressive changes in the heart, lungs, nervous system, and other organs can alter how the fetus handles oxygen, nutrients, signaling, and waste. Measuring these linked changes helps investigators relate cellular or molecular disturbances to recognizable developmental and physiological outcomes.
Researchers examine fetal mouse physiology to connect developmental disturbances with functional consequences before birth. The model supports studies of developmental disorders and congenital abnormalities by allowing investigators to relate changes in organ maturation, fetal circulation, or maternal–placental exchange to physiological outcomes. This approach can help identify how cellular and molecular mechanisms contribute to disease-relevant development.
Prenatal exposure studies can evaluate how conditions encountered before birth affect fetal development and physiological function. Investigators may examine resulting changes in organ maturation, circulation, or the exchange of oxygen and nutrients across the placenta. Such findings help clarify how an exposure becomes linked to developmental abnormalities or altered outcomes relevant to medicine.
Fetal mouse studies provide a setting for examining responses to experimental treatments during development. Researchers can compare treatment-associated physiological outcomes with changes in fetal organ maturation, circulation, or maternal–placental exchange. Because many developmental pathways are conserved across mammals, these observations can help connect experimental findings with mechanisms and disease questions relevant to human medicine.