Ventricular Lead
Ventricular Lead - Related Videos
09:40
Lead Analysis of Soil Using Atomic Absorption Spectroscopy
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2023
Source: Laboratories of Margaret Workman and Kimberly Frye - Depaul University Lead occurs naturally in soil, in levels ranging from 10-50 ppm. However, with the widespread use of lead in paint and gasoline in addition to contamination by industry, urban soils often have concentrations of lead significantly greater than background levels – up to 10,000 ppm in some places. Ongoing problems arise from the fact that lead does not biodegrade, and instead remains in the soil. Serious health risks...
08:49
Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
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Cited by 4 •
2018
Here, we present a protocol using two centrifugal pumps as a total artificial heart replacement.
09:22
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
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Cited by 22 •
2015
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Right Ventricular (RV) dysfunction were induced in piglets by progressive obstruction of the pulmonary arteries. Consequences were remarkably similar to those observed in CTEPH patients. This animal model would be a very useful tool for pathophysiology and therapeutic experiments on CTEPH and RV failure.
11:33
Isolation and Kv Channel Recordings in Murine Atrial and Ventricular Cardiomyocytes
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Cited by 15 •
2013
Kv channel dysfunction is associated with cardiac arrhythmias. In order to study the molecular mechanisms that lead to such arrhythmias we utilize a systematic protocol for isolation of atrial and ventricular cardiomyocytes from Kv channel ancillary subunit knockout mice. Isolated cardiomyocytes can then immediately be used for cellular electrophysiological studies, biochemical or immunofluorescence (IF) assays.
07:51
Murine Short Axis Ventricular Heart Slices for Electrophysiological Studies
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Cited by 3 •
2017
Here, we describe the preparation of viable ventricular slices from adult mice and their use for sharp electrode action potential recordings. These multicellular preparations provide a preserved in vivo like tissue structure, which makes them a valuable model for electrophysiological and pharmacological studies in vitro.
FAQs
The lead’s electrode senses intrinsic ventricular depolarization, the electrical activation associated with the ventricle’s own rhythm. This information allows the implanted device to recognize whether ventricular activity is occurring and determine whether electrical support is needed. Monitoring intrinsic activity helps the system respond to inadequate ventricular timing rather than stimulating without regard to the heart’s current electrical state.
Precisely timed impulses can support ventricular contraction when the intrinsic ventricular rate or conduction is inadequate. Timing allows the device to regulate rhythm in relation to detected cardiac activity, which is important for maintaining appropriate ventricular pacing rather than delivering stimulation indiscriminately. This function supports treatment of bradyarrhythmias and other problems involving insufficient ventricular activation.
In a pacemaker system, the ventricular lead primarily supports rhythm regulation through sensing and electrical stimulation. In an implantable cardioverter-defibrillator system, the lead can also support delivery of therapeutic shocks. Thus, the same general connection to the ventricle may contribute to different device functions, ranging from correcting inadequate pacing support to providing shock-based therapy.
The placement approach depends mainly on the implanted device and the patient’s anatomy. A ventricular lead may be introduced through the venous system or attached during surgery when that approach is appropriate. Considering these factors helps clinicians select a route compatible with the device design and the individual cardiac or vascular anatomy.
Placement connects the lead to the ventricular portion of the heart while establishing its connection with the implanted device. Depending on the clinical situation, this may occur through the venous system or as a surgical attachment. The selected approach reflects both the device involved and anatomical considerations, rather than following one identical route for every patient.
Ventricular leads are relevant when inadequate ventricular rate or conduction creates a need for device-based rhythm support. They can assist in treating bradyarrhythmias, support coordinated pacing, and contribute to monitoring cardiac rhythm. In defibrillator systems, their shock-delivery capability adds another therapeutic role, linking ventricular electrical activity with treatment when the device requires it.