Neuronal Firing
Neuronal Firing - Related Videos
12:47
Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
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Cited by 8 •
2014
Here we describe an adaptation of protocols used to induce homeostatic plasticity in neurons for the study of plasticity of astrocytic G protein-coupled receptors. Recently used to examine changes in astrocytic group I mGluRs in juvenile mice, the method can be applied to measure scaling of various astrocytic GPCRs, in tissue from adult mice in situ and in vivo, and to gain a better appreciation of the sensitivity of astrocytic receptors to changes in neuronal activity.
09:27
Wind Tunnel Experiments to Study Chaparral Crown Fires
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Cited by 7 •
2017
This protocol describes wind tunnel experiments designed to study the transition of a fire from the ground to the canopy of chaparral shrubs.
04:25
Simultaneous Eye Tracking and Single-Neuron Recording to Identify Target-Selective Neurons
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2025
The video demonstrates an assay to identify target-selective neurons via simultaneous eye-tracking and single-neuron recordings. A human participant is tasked with identifying a target object among an array of objects in a display, and the eye movement is tracked. Simultaneously, single neurons' firing rate is recorded via electrodes implanted in the brain. The data from both recordings are correlated to assess the presence of target-selective neurons.
07:17
Photoselective Vaporesection of the Prostate via an End-firing Lithium Triborate Crystal Laser
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2018
Here we present a protocol to perform Photoselective Vaporesection of the Prostate (PVRP) for benign prostatic hyperplasia (BPH) treatment.
08:04
Neuronal Transfection Methods
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2023
Transfection - the process of transferring genetic material into cells - is a powerful tool for the rapid and efficient manipulation of gene expression in cells. Because this method can be used to silence the expression of specific proteins or to drive the expression of foreign or modified proteins, transfection is an extremely useful tool in the study of the cellular and molecular processes that govern neuron function. However, mature neurons have a number of properties that make them...
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The sequence creates a brief, coordinated change in membrane voltage. Opening voltage-gated sodium channels drives depolarization, while subsequent potassium channel activation supports repolarization. This ordering allows the electrical signal to progress through the neuron rather than remaining a sustained voltage change. Its importance lies in producing a discrete signal that can support reliable neural communication.
Neuronal firing can represent information through both when signals occur and how often they occur. Timing relates activity to events across a neural circuit, whereas frequency reflects the rate of repeated activity. Examining these features helps connect electrical signaling with synaptic communication, sensory processing, movement, and behavior without treating every action potential as identical information.
Restoring ion gradients returns the membrane to a state that can support subsequent activity. Without this recovery, the changing distribution of ions would not be reset for continued signaling. In experimental interpretation, recovery is therefore relevant when considering repeated firing, because observed patterns depend not only on the initial electrical event but also on preparation for later activity.
Researchers can examine the timing and frequency of activity and relate those patterns to synaptic communication within a circuit. Comparing firing behavior with sensory processing, movement, or behavior helps identify how electrical signals participate in coordinated functions. This approach shifts attention from an isolated signal to the organization and activity of interconnected neurons.
Firing patterns are relevant to several nervous-system functions, including synaptic communication, sensory processing, movement, and behavior. Their timing and frequency provide information about how neural activity is organized during these functions. Studying those relationships helps neuroscience connect cellular electrical events with larger processes carried out by neural circuits.
Changes in neuronal excitability can produce altered firing behavior, making electrical activity a useful focus for studying neurological disorders. Researchers can examine whether timing, frequency, or the ability to sustain subsequent activity differs from expected patterns. Relating these changes to neural-circuit function may clarify how disrupted cellular signaling contributes to abnormal nervous-system activity.