Stroke Imaging

Stroke imaging comprises diagnostic techniques that visualize brain tissue and blood vessels to identify stroke, determine its cause, and guide urgent treatment. Computed tomography rapidly detects hemorrhage and early structural changes, while magnetic resonance imaging uses diffusion-sensitive sequences to reveal restricted water movement in ischemic tissue; angiography and perfusion methods can further show vessel occlusion and impaired blood flow. In neuroscience and clinical care, these modalities distinguish ischemic from hemorrhagic stroke, estimate the extent of injury, and help determine eligibility for reperfusion therapies. Imaging also supports outcome prediction, treatment monitoring, and research into cerebrovascular mechanisms and brain recovery.

Stroke Imaging - Related Videos

Research

JoVE Journal - Neuroscience
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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

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Cited by 17 •

2017

A protocol for stroke onset time estimation in a rat model of stroke exploiting quantitative magnetic resonance imaging (qMRI) parameters is described. The procedure exploits diffusion MRI for delineation of the acute stroke lesion and quantitative T1 and T2 (qT1 and qT2) relaxation times for timing of stroke.

Research

JoVE Journal - Medicine

Rose Bengal Photothrombosis by Confocal Optical Imaging In Vivo: A Model of Single Vessel Stroke

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Cited by 31 •

2015

Here, we describe a semi-invasive optical microscopy approach for the induction of a Rose Bengal photothrombotic clot in the somatosensory cortex of a mouse in vivo. The technical aspects of the imaging procedure are described from induction of a photothrombotic event to application and data collection.

Magnetic Resonance Imaging of Perivascular Spaces in the Human Brain During a Small Vessel Stroke

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2025

Perivascular spaces (PVS) are fluid-filled spaces around the brain blood vessels involved in fluid drainage.To examine alterations in PVS during a small vessel stroke, perform magnetic resonance imaging (MRI) of the basal ganglia region in the patient’s brain.The imaging protocol includes the T2-weighted fast spin echo and fluid-attenuated inversion recovery (FLAIR) sequences.T2-weighted imaging enhances the contrast between cerebrospinal fluid (CSF)-filled PVS and surrounding tissue.FLAIR...

Research

JoVE Journal - Medicine
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Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

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Cited by 104 •

2014

Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.

Research

JoVE Journal - Neuroscience
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The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

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2025

To simulate thromboembolic stroke, emboli prepared from heterologous rat blood were injected into the middle cerebral artery, followed by administration of systemic thrombolysis for recanalization. This version of the model is optimized for use in a multi-laboratory network and supports testing multiple candidate therapeutics.

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