Microfluidic Prototyping
Microfluidic Prototyping - Related Videos
07:51
High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods
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2013
In this article we describe different techniques for microfluidic rapid prototyping platforms. The proposed techniques are based on ultraviolet (UV) sensitive and temperature curing epoxies, polydimethylsiloxane (PDMS) based tubing, wire-bonding, and anisotropic adhesive films. The assembling procedures presented are developed for both one-time use devices as well as reusable microfluidic systems.
13:59
Reduced-gravity Environment Hardware Demonstrations of a Prototype Miniaturized Flow Cytometer and Companion Microfluidic Mixing Technology
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Cited by 9 •
2014
Spaceflight blood diagnostics need innovation. Few demonstrations have been published illustrating in-flight, reduced-gravity health diagnostic technology. Here we present a method for construction and operation of a parabolic flight test rig for a prototype point-of-care flow-cytometry design, with components and preparation strategies adaptable to other setups.
10:35
Studies of Bacterial Chemotaxis Using Microfluidics - Interview
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Cited by 1 •
2007
01:24
Concepts and Prototypes
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2025
The human nervous system handles vast amounts of information by translating sensory stimuli into neural impulses, which the brain processes, creating thoughts expressed through language or stored as memories. The brain also synthesizes information from emotions and memories, which significantly influence thoughts and behaviors. This intricate process creates a comprehensive mental picture. The brain organizes this information using concepts, which are mental categories grouping linguistic data,...
07:50
Detection and Removal of Nuclease Contamination During Purification of Recombinant Prototype Foamy Virus Integrase
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Cited by 10 •
2017
Recombinant prototype foamy virus integrase protein is often contaminated with a bacterial nuclease during purification. This method identifies nuclease contamination and removes it from the final preparation of the enzyme.
FAQs
Computer-aided design allows researchers to plan channel networks before fabrication, while soft lithography, laser cutting, and 3D printing provide different routes for producing the device structure. Using these approaches in a prototyping workflow supports rapid design changes, helping teams refine channel layouts and device configurations without committing immediately to lengthy or material-intensive production.
Fluid movement depends on pumps, pressure differences, and surface tension. These forces regulate how liquids travel through the channel network and interact with one another, making it possible to manage transport and mixing at small scales. Their control is important when experiments require consistent fluid handling while using only limited sample volumes.
Bonding joins the channel layers to form sealed pathways. Without this step, the fabricated structures would not provide an enclosed route for controlled fluid movement. Sealed channels allow pumps, pressure differences, and surface tension to act within the intended network, supporting reliable flow and mixing during bioengineering experiments.
A typical workflow begins with computer-aided design of the channel network, followed by fabrication using soft lithography, laser cutting, or 3D printing. The resulting layers are then bonded to seal the pathways. Researchers can subsequently integrate fluid-control conditions, such as pumping or pressure differences, to evaluate flow and mixing in the prototype.
This approach is useful when researchers need to develop or refine devices for cell culture, biomolecule analysis, point-of-care diagnostics, or organ-on-chip models. Prototyping supports rapid iteration, so designs can be adjusted as experiments progress. Its small-scale format also reduces material use, which is valuable when samples or reagents are limited.
Microfluidic prototypes can provide platforms for conducting controlled cell-culture studies, analyzing biomolecules, developing point-of-care diagnostic systems, and constructing organ-on-chip models. Their channel networks enable precise fluid handling with minimal sample volumes. The combination of rapid fabrication and reduced material use helps researchers explore device designs efficiently across these applications.