Folate-modified Nanoparticles
Folate-modified Nanoparticles - Related Videos
02:53
Functionalized Nanoparticle Targeting of Ovarian Cancer: A Technique to Facilitate Folic Acid-conjugated Nanoparticle Contrast Agent Uptake by Ovarian Cancer Cells
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2023
In this video, we demonstrate a technique to facilitate the internalization of folic acid-capped copper sulfide nanoparticles (CuS NPs). Folic acid-functionalized CuS NPs have the ability to target folate-receptors which are overexpressed in many ovarian cancer cells.
08:35
Therapeutic Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-targeted Gelatin Nanoparticles
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Cited by 28 •
2012
Type B gelatin-based engineered nanovectors system (GENS) was developed for systemic gene delivery and transfection in the treatment of pancreatic cancer. By modification with epidermal growth factor receptor (EGFR) specific peptide on the surface of nanparticles, they could target on EGFR receptor and release plasmid under reducing environment, such as high intracellular glutathione concentrations.
08:42
Determination of Zeta Potential via Nanoparticle Translocation Velocities through a Tunable Nanopore: Using DNA-modified Particles as an Example
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Cited by 7 •
2016
Here we use a polyurethane tunable nanopore integrated into a resistive pulse sensing technique to characterize nanoparticles surface chemistry via the measurement of particle translocation velocities, which can be used to determine the zeta potential of individual nanoparticles.
07:34
Gold Nanoparticle Modified Carbon Fiber Microelectrodes for Enhanced Neurochemical Detection
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Cited by 20 •
2019
In this study, we modify carbon-fiber microelectrodes with gold nanoparticles to enhance the sensitivity of neurotransmitter detection.
09:23
Harmonic Nanoparticles for Regenerative Research
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Cited by 1 •
2014
Protocol details are provided for in vitro labeling human embryonic stem cells with second harmonic generating nanoparticles. Methodologies for hESC investigation by multi-photon microscopy and their differentiation into cardiac clusters are also presented.
FAQs
Folate first binds folate receptors on the cell surface, creating a recognition event that can trigger receptor-mediated endocytosis. The cell then internalizes the associated nanoparticle and its payload rather than leaving the material only at the membrane. In cancer research, this mechanism helps investigators examine whether receptor engagement improves intracellular delivery of drugs, nucleic acids, or imaging compounds.
Folate receptor expression provides the cellular feature that the surface folate is intended to recognize. Cells expressing these receptors may interact more readily with the modified nanoparticles, supporting more selective targeting than delivery based only on nonspecific cellular contact. Researchers therefore consider receptor-mediated interaction when studying nanoparticle localization, cellular uptake, and the potential selectivity of cancer-directed delivery.
The payload determines what researchers can investigate after nanoparticle uptake. Chemotherapeutic agents support studies of treatment response, nucleic acids enable investigation of intracellular delivery, and imaging compounds help visualize nanoparticle or payload localization. Using the same targeting strategy with different payload classes allows cancer researchers to examine how folate-mediated uptake relates to therapeutic effects, molecular delivery, or imaging outcomes.
Nanoscale delivery provides a carrier for transporting a selected payload, while folate recognition supplies a receptor-directed interaction with cells. Their combination may improve where the payload is localized and helps researchers connect cellular recognition with delivery behavior. This relationship is important when evaluating whether targeted systems can produce useful treatment responses while informing studies of toxicity and therapeutic development.
Studies commonly examine cellular uptake, treatment response, and toxicity. Uptake measurements address whether receptor engagement is associated with nanoparticle entry, whereas response studies assess the effects of carried chemotherapeutic agents or other payloads. Toxicity analysis adds information about unwanted effects. Together, these outcomes help researchers judge delivery behavior and the suitability of the system for further cancer research.
These systems support several complementary cancer research applications. Researchers can investigate delivery of chemotherapeutic agents, explore transport of nucleic acids, or use imaging compounds to study localization. The approach also supports analysis of receptor-mediated cellular entry and treatment response. By linking targeting behavior with payload function, it contributes to the development and evaluation of more selectively directed cancer therapies.