Renal Transplantation
Renal Transplantation - Related Videos
18:48
Murine Renal Transplantation Procedure
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Cited by 20 •
2009
Renal transplantation in mice is a technically challenging procedure that requires careful post-operative care and treatment for success.
08:58
Murine Kidney Transplant Technique
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Cited by 8 •
2015
The goal of this manuscript is to describe the steps required to perform a kidney transplant in a mouse, paying particular attention to the details of the arterial anastomosis.
10:42
Normothermic Machine Perfusion of Rat Kidneys for Transplantation
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2026
This protocol describes the ex vivo normothermic machine perfusion of a rat kidney for subsequent transplantation into a recipient rat.
04:44
Renal Organotypic Culture on Chicken CAM: A Technique for Transplantation of Murine Kidney Explants on Chicken CAM to Induce Formation of Renal Vascular Architecture
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2023
This video describes a method for studying organ development using an improved xenotransplantation setup on chorioallantoic membrane (CAM) from avian embryos. This method allows for the development of fully vascularized cultured embryonic organs and organoids.
06:59
A Rat Orthotopic Renal Transplantation Model for Renal Allograft Rejection
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Cited by 2 •
2022
The rat orthotopic renal transplantation model contributes to investigating the mechanism of renal allograft rejection. The current model increases the recipients' survival without interference with blood supply and venous reflux of the lower body using an end-to-end anastomosis of kidney implantation and an end-to-side "tunnel" method of ureter-bladder anastomosis.
FAQs
Matching helps clinicians evaluate how well a donor kidney corresponds with the intended recipient before transplantation. This assessment is part of the broader effort to limit immune recognition of donor tissue, because the recipient’s immune system can identify the graft as foreign. Careful matching therefore supports the goal of reducing rejection risk and promoting longer-term graft survival.
Immunosuppressive medicines reduce the recipient’s immune recognition of donor tissue after surgery. By limiting this response, they help prevent rejection and support continued graft function. Their use must be accompanied by infection prevention and ongoing clinical assessment, since long-term transplant care depends on balancing protection of the kidney with attention to the patient’s overall health.
Ongoing assessment shows whether the transplanted kidney continues to function effectively and helps clinicians support graft survival over time. Monitoring is not limited to the immediate postoperative period; it remains part of long-term care alongside immunosuppressive treatment and infection prevention. These measures also help relate kidney performance to the patient’s broader health and quality of life.
During the operation, the donor kidney is connected to the recipient’s blood vessels so it can participate in circulation, and its urinary tract is connected to the recipient’s urinary system. These surgical connections allow the graft to carry out its intended role after implantation. Postoperative monitoring then assesses kidney function and supports detection of problems affecting graft survival.
Kidneys for transplantation may come from either living donors or deceased donors. Regardless of donor source, careful donor–recipient matching remains an important part of the process, and the recipient requires immunosuppressive medicines to reduce immune recognition of donor tissue. The donor categories therefore broaden potential access to transplantation while preserving the need for compatibility assessment and long-term follow-up.
Renal transplantation is an established treatment option for end-stage kidney disease. Compared with continued dependence on dialysis, a successful transplant can improve quality of life and reduce the need for dialysis. Its benefits depend on sustained graft function, immunosuppressive treatment, infection prevention, and long-term assessment, so transplantation represents an ongoing care pathway rather than a single procedure.
Current research aims to limit rejection, expand donor options, and improve outcomes after transplantation. These priorities address major challenges across the transplant pathway, including immune responses to donor tissue, the availability of suitable kidneys, and the durability of graft function. Progress in these areas could extend access to treatment and strengthen long-term health for transplant recipients.