Icr Mice
Icr Mice - Related Videos
08:17
Chemical Analysis of Water-accommodated Fractions of Crude Oil Spills Using TIMS-FT-ICR MS
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Cited by 10 •
2017
The low-energy water-accommodated fraction (LEWAF) of crude oil is a challenging system to analyze, because over time, this complex mixture undergoes chemical transformations. This protocol illustrates methods for the preparation of the LEWAF sample and for performing photo-irradiation and chemical analysis by trapped ion mobility spectrometry–FT-ICR MS.
08:10
A Mouse Model of Subchronic and Mild Social Defeat Stress for Understanding Stress-induced Behavioral and Physiological Deficits
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Cited by 25 •
2015
Here, methods for developing a mouse model of subchronic and mild social defeat stress are described and used to investigate the pathogenic features of depression including hyperphagia- and polydipsia-like symptoms following increased body weight.
06:17
Measuring the Strength of Mice
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Cited by 287 •
2013
Deficits in muscular strength occur in many clinical conditions such as motor neuron disease. The inverted screen and weight lifting tests described here measure strength in mice almost exclusively, with minimal influence of factors such as coordination.
36:30
Small Bowel Transplantation In Mice
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Cited by 2 •
2007
The mouse small bowel transplantation model has been recognized as an important tool to study mechanismes of immune rejection and screen new immunosuppressive drugs. However, this model is limited to use because the techniques involved is an extremely technically challenge. Now we introduce the modified technique.
07:02
Trace Fear Conditioning in Mice
0 Views •
Cited by 32 •
2014
In the following experiment we describe a protocol for trace fear conditioning in mice. This type of associative memory includes a trace period that separates the neutral stimulus and the unconditioned stimulus.
FAQs
Genetic diversity is maintained through the outbred breeding structure, so individual ICR mice can differ in traits relevant to neural research. Those differences may appear in behavior, physiology, or sensitivity to a drug. As a result, measured responses represent a range across animals rather than a single highly uniform profile, which is useful when biological variation is part of the question.
Compared with inbred lines, ICR mice are better suited to questions that require variation among individuals. Inbred animals tend to provide more uniform genetic backgrounds, whereas ICR mice can show differing behavioral, physiological, or treatment responses. This contrast helps researchers choose a model based on whether they prioritize reduced background variation or representation of biological diversity.
Variation in drug sensitivity can reveal that a neural or behavioral treatment does not affect every individual in the same way. Using ICR mice allows researchers to observe that spread of responses rather than treating one response as universally representative. This is especially relevant to neuropharmacology and treatment-outcome studies in which genetic background may influence the result.
Behavioral assays, neuropharmacology, toxicology, and studies of development or stress are appropriate contexts when researchers want neural outcomes considered alongside biological variation. In these settings, the stock can help examine how differences among animals relate to behavior, physiology, drug sensitivity, or disease-related phenotypes. Its value comes from matching the model to the scientific question.
Variation should be treated as informative rather than automatically as experimental noise, provided it matches the study’s aim. Researchers can consider how individual differences in genetic background may contribute to behavioral, physiological, or drug-related outcomes. This interpretation supports conclusions about response ranges and disease-related phenotypes, rather than conclusions based only on a uniform response.
Development and stress can produce neural or behavioral outcomes that differ among individuals. Because ICR mice retain genetic diversity, they provide a model for examining such outcomes when the researcher wants variation to remain visible. This can complement studies focused on uniformity by asking how genetic background may shape neural function or disease-related phenotypes across animals.