Myelin Plasticity
Myelin Plasticity - Related Videos
00:58
Plasticity
0 Views •
2023
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
01:31
Plasticizers
0 Views •
2024
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas. Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
10:12
Extraction of Organochlorine Pesticides from Plastic Pellets and Plastic Type Analysis
0 Views •
Cited by 10 •
2017
Microplastics act as vector of potentially toxic organic contaminants with unpredictable effects. This protocol describes an alternative methodology for assessing the levels of organochlorine pesticides adsorbed on plastic pellets and identifying the polymer chemical structure. The focus is on pressurized fluid extraction and attenuated total reflectance Fourier transform infrared spectroscopy.
01:23
A Gold Staining Technique to Visualize Myelin Reduction in Stressed Mice
0 Views •
2025
Stress impairs oligodendrocyte function, disrupting the lipid-rich myelin sheath surrounding neuronal axons in the medial prefrontal cortex, a brain region regulating emotion.
03:59
Isolation and Purification of Recombinant Myelin Oligodendrocyte Glycoproteins
0 Views •
2025
Source: Jain, R. W., et al. Simple and Efficient Production and Purification of Mouse Myelin Oligodendrocyte Glycoprotein for Experimental Autoimmune Encephalomyelitis Studies. J. Vis. Exp. (2016)This video demonstrates the isolation and purification of MOGtag, a recombinant Myelin Oligodendrocyte Glycoprotein (MOG) used in Experimental Autoimmune Encephalomyelitis (EAE) studies. The protocol involves bacterial lysis, sonication, centrifugation, and nickel affinity chromatography to obtain...
FAQs
Oligodendrocytes can alter three features of myelin: formation, thickness, and distribution along axons. These changes modify how electrical signals travel and can influence the timing of communication among neural circuits. This cellular flexibility provides a mechanism through which glial cells contribute to circuit-level adaptation during development or experience.
Neural activity and experience can serve as signals associated with changes in myelin formation, thickness, or placement around axons. By modifying these properties, the nervous system may adjust electrical conduction and communication timing as circuits develop or respond to experience. This relationship offers a cellular explanation for how learning and adaptive behavior can influence network function.
Communication timing matters because changes in myelin can alter the speed at which electrical signals travel along axons. Adjusting when signals reach their targets may influence coordination within neural circuits, not merely whether signals are transmitted. For neuroscience, this connects structural changes around individual axons with broader changes in network function and adaptive behavior.
Remyelination represents an important research context in which myelin restoration is considered after injury or disease. Myelin plasticity provides a broader framework that also includes changes associated with development, neural activity, and experience. Studying both perspectives can connect cellular responses in oligodendrocytes with recovery processes and potential therapeutic strategies for demyelinating disorders.
A useful research approach links changes at the cellular level with effects at the circuit level. Investigators can examine oligodendrocyte-related changes in myelin formation, thickness, or distribution, then relate them to electrical conduction and communication timing. Connecting these scales helps determine how neural activity or experience may contribute to altered network function.
Myelin plasticity is relevant to research on learning, adaptive behavior, neural development, and recovery after injury or disease. It helps explain how changes in glial cells may influence circuit operation and also supports investigation of remyelination. These applications make the topic important both for understanding normal nervous-system adaptation and for exploring strategies related to demyelinating disorders.