Allergies Anaphylaxis
Allergies Anaphylaxis - Related Videos
04:34
Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
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Cited by 44 •
2018
Here we present a new method to accurately measure body temperature differences in passive systemic anaphylaxis (PSA) and food allergy mouse models using an infrared thermometer. This procedure has been accurately duplicated in previous PSA results.
07:22
Basophil Activation Test for Allergy Diagnosis
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Cited by 9 •
2021
The basophil activation test is a complementary in vitro diagnostic test for the evaluation of IgE-mediated allergic reactions based on the detection of basophil activation in the presence of a specific stimulus through the measure of activation markers by flow cytometry.
01:30
Allergic Reactions: Anaphylaxis
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2026
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
07:49
Measuring Local Anaphylaxis in Mice
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Cited by 29 •
2014
Allergic responses, characterized by the activation of mast cells and basophils, are driven by the cross-linking of IgE and release of proinflammatory mediators. A quantitative assessment of allergic responses can be achieved by using Evans Blue dye to monitor changes in vascular permeability after allergen challenge.
06:34
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Cited by 4 •
2017
This work describes a protocol that uses a component-resolved approach to study sensitization to grass pollen allergens in a cohort of patients from southern China with allergic rhinitis and/or asthma.
FAQs
Cross-linking allergen-bound IgE on mast cells and basophils causes these cells to release histamine and other mediators. Their combined effects increase vascular dilation and tissue swelling, narrow airway smooth muscle, produce hives, and stimulate gastrointestinal symptoms. Because several organ systems can respond at once, the clinical picture may extend beyond isolated skin or respiratory findings.
Epinephrine addresses several dangerous physiological changes simultaneously through adrenergic receptor stimulation. It supports blood pressure by counteracting excessive vasodilation and relaxes airway smooth muscle, helping reduce airway narrowing. This broad pharmacological action makes intramuscular epinephrine central to emergency management, rather than relying on a treatment aimed at only one symptom or organ system.
The key issue is the speed and breadth of mediator release after immune activation. Histamine and related substances can affect blood vessels, airway smooth muscle, skin, and the gastrointestinal tract in a short period. Pharmacology therefore emphasizes rapid recognition of evolving, multisystem effects and prompt intervention before airway or circulatory problems become more severe.
Pharmacology connects the underlying immune mechanism with the pattern and severity of physiological effects. A reaction involving symptoms across systems such as airway narrowing, swelling, hives, gastrointestinal effects, or impaired blood pressure requires greater concern than a limited response. This framework supports treatment decisions and helps organize emergency care around the most dangerous manifestations.
Emergency management centers on recognizing the reaction and administering intramuscular epinephrine to stimulate adrenergic receptors. Clinicians then use additional treatments and monitoring as needed, guided by the patient’s ongoing physiological response. This approach targets immediate airway and circulatory threats while allowing care to adapt if symptoms persist, progress, or involve additional organ systems.
Epinephrine provides the primary adrenergic support, but anaphylaxis may require additional treatments and continued monitoring. These measures help clinicians follow airway, circulatory, skin, and gastrointestinal effects and assess whether the response is improving. The broader pharmacological plan is therefore not limited to one injection; it includes reassessment and supportive decisions based on evolving findings.
Mechanistic and pharmacological understanding identifies points where allergic responses can be recognized, interrupted, or reduced. Knowledge of IgE, mast cells, basophils, released mediators, and adrenergic treatment informs emergency care while also supporting risk-reduction strategies and the development of safer allergy therapies. This links acute treatment with longer-term efforts to improve allergy management.