Muscle Twitching Fasciculations

Muscle twitching, or fasciculations, consists of involuntary, brief contractions of individual motor units that appear as rippling movements beneath the skin. These contractions occur when motor neurons or muscle fibers fire spontaneously, reflecting altered neuromuscular excitability that may result from fatigue, electrolyte disturbances, nerve irritation, or medication effects. In pharmacology, fasciculations can signal an adverse drug reaction or changes in peripheral nerve and muscle function, making them relevant to medication safety and neuromuscular assessment. Evaluating their timing, distribution, severity, and relationship to drug exposure helps distinguish transient effects from patterns requiring further clinical investigation.

Muscle Twitching Fasciculations - Related Videos

Research

JoVE Journal - Immunology and Infection

Visualization of Twitching Motility and Characterization of the Role of the PilG in Xylella fastidiosa

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Cited by 5 •

2016

In this study, a nano-microfluidic flow chamber was employed to visualize and functionally characterize the twitching motility of Xylella fastidiosa, a bacterium that causes Pierce's disease in grapevine.

Research

JoVE Journal - Biology
Free Sample

Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice

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Cited by 75 •

2013

Changes in limb muscle contractile and passive mechanical properties are important biomarkers for muscle diseases. This manuscript describes physiological assays to measure these properties in the murine extensor digitorum longus and tibialis anterior muscles.

Education

JoVE Core - Biology

Classification of Skeletal Muscle Fibers

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2019

Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions. Slow-Twitch Muscle Fibers Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...

Research

JoVE Journal - Medicine
Free Sample

In Vivo Canine Muscle Function Assay

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Cited by 19 •

2011

We describe a minimally-invasive and painless method to measure canine hindlimb muscle strength and muscle response to repeated eccentric contractions.

Research

JoVE Journal - Medicine
Free Sample

Myo-mechanical Analysis of Isolated Skeletal Muscle

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Cited by 25 •

2011

To assess the in vivo effects of therapeutic interventions for muscle disease, methods are needed to quantitate force generation and fatigability in treated muscle. We detail an approach to evaluating myo-mechanical properties in explanted mouse hindlimb muscle. This analysis provides a robust approach to quantitating the effects of genetic modification on muscle function, as well as comparison of therapies in mouse models of muscle disease.

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