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Anestesia e intubación de cachorros de ratón preadolescentes para cirugía cardiotorácica
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Anestesia e intubación de cachorros de ratón preadolescentes para cirugía cardiotorácica

Article DOI: 10.3791/64004-v • 09:47 min • June 2nd, 2022
June 2nd, 2022 •
*1, 1,2, 3,4, 1,2, 1,2, *1,2
1Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, 2St Vincent’s Clinical School, University of New South Wales Sydney, 3Department of Anaesthesia, The Children’s Hospital at Westmead, 4School of Child and Adolescent Health, University of Sydney
* These authors contributed equally

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Los modelos quirúrgicos cardiotorácicos en ratones de >7 días de edad requieren intubación, pero esto es un desafío para las crías de ratón preadolescentes (8-14 días de edad) y hay poca información sobre los regímenes anestésicos para la intubación. Aquí, presentamos regímenes de dosificación de ketamina / xilazina / atropina en crías de ratón C57BL / 6J de 10 días de edad que permiten la intubación endotraqueal, al tiempo que minimizan la mortalidad animal.

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Biología Número 184
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