Large animal models of cardiovascular disease, from training to translation.
Fundación Centro de Cirugía de Mínima Invasión Jesús Usón, and CIBERCV, Instituto de Salud Carlos III, Spain
Dr. Verónica Crisóstomo is the Head of Cardiovascular Research at the Jesús Usón Minimally…
Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)
Dr. Claudia Báez Díaz is a Doctoral Researcher at the Centro de Investigación Biomédica en…
Cardiovascular diseases (CVDs) are a huge major health concern worldwide, and hence a priority in biomedical research. Large animal models help researchers to evaluate the safety and efficacy of new cardiovascular procedures and devices in systems that resemble the human anatomy; additionally, they can be used to emulate scenarios for training purposes. For device development, preclinical studies in large animal models are an essential step in the translation path. This collection aims to help researchers understand and select those models best suited to achieve the aims of their research, to facilitate the humane care and management of their research animals and to promote the high ethical standards required of animal research. Such models can also be used for training, allowing medical professionals to learn and practice challenging techniques in anatomy that closely simulates human systems.
In the clinical scenario, diagnosis and therapy of cardiovascular diseases relies heavily in image guidance, and therefore in this collection we will showcase how these imaging techniques, when used in the preclinical lab, help bridge the gap from bench to bedside. The focus of this collection includes, but is not limited to, large animal (swine, sheep, etc.) models developed surgically or interventionally, as well as the use of clinical grade imaging techniques (Magnetic Resonance imaging, fluoroscopy, Ultrasonography, electromechanical mapping, etc. ) aimed to advance our understanding of CVDs and the reproducibility of experiments.