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Methods Collections

Large animal models of cardiovascular disease, from training to translation.

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Methods Collections
Large animal models of cardiovascular disease, from training to translation.

Guest Editors
Verónica Crisóstomo

Fundación Centro de Cirugía de Mínima Invasión Jesús Usón, and CIBERCV, Instituto de Salud Carlos III, Spain

Dr. Verónica Crisóstomo is the Head of Cardiovascular Research at the Jesús Usón Minimally…

Claudia Báez Díaz

Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV)

Dr. Claudia Báez Díaz is a Doctoral Researcher at the Centro de Investigación Biomédica en…

Collection Overview

Cardiovascular diseases (CVDs) are a huge major health concern worldwide, and hence a priority in biomedical research. Large animal models help researchers to evaluate the safety and efficacy of new cardiovascular procedures and devices in systems that resemble the human anatomy; additionally, they can be used to emulate scenarios for training purposes. For device development, preclinical studies in large animal models are an essential step in the translation path. This collection aims to help researchers understand and select those models best suited to achieve the aims of their research, to facilitate the humane care and management of their research animals and to promote the high ethical standards required of animal research. Such models can also be used for training, allowing medical professionals to learn and practice challenging techniques in anatomy that closely simulates human systems.

In the clinical scenario, diagnosis and therapy of cardiovascular diseases relies heavily in image guidance, and therefore in this collection we will showcase how these imaging techniques, when used in the preclinical lab, help bridge the gap from bench to bedside. The focus of this collection includes, but is not limited to, large animal (swine, sheep, etc.) models developed surgically or interventionally, as well as the use of clinical grade imaging techniques (Magnetic Resonance imaging, fluoroscopy, Ultrasonography, electromechanical mapping, etc. ) aimed to advance our understanding of CVDs and the reproducibility of experiments.

Abstracts

Swine models of aneurysmal diseases for training and research.

Virginia Blanco-Blázquez*1, Claudia Báez-Diaz1, Francisco Miguel Sánchez-Margallo2, Javier Vela3, Elena Abellán3, Verónica Crisóstomo1
11.-Cardiovascular Area, Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain; 2.-Centro de Investigación Biomédica En Red de Enfermedades Cardiovasculares CIBERCV, Madrid, Spain (CB16/11/00494)., 22.-Centro de Investigación Biomédica En Red de Enfermedades Cardiovasculares CIBERCV, Madrid, Spain (CB16/11/00494). 3.- Scientific Director, Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain, 34- Microsurgery Unit, Jesús Usón Minimally Invasive Surgery Centre, Cáceres, Spain.

SURGICAL INDUCTION OF MYOCARDIAL INFARCTION IN THE SWINE MODEL

Elena Abellán*1, Francisco Javier Vela1, José Luis Campos1, Virginia Blanco-Blázquez2, Laura C. Pires-Louçã1, María Jesús Jara1, Francisco Miguel Sánchez-Margallo3
1Microsurgery Unit. Jesús Usón Minimally Invasive Surgery Centre, 2Cardiovascular Research. Jesús Usón Minimally Invasive Surgery Centre and CIBER-CV, Instituto Salud Carlos III, 3Jesús Usón Minimally Invasive Surgery Centre and CIBER-CV, Instituto Salud Carlos III

An animal model for Training in Interventional Cardiology of Structural Heart Disease: the ePICIA Course

Felipe Fernandez-Vazquez1, Armando Perez de Prado*1, Jose Manuel Gonzalo Orden2, Marta Regueiro Purriños2, Carlos Cuellas Ramón1, Maria Lopez Benito1, Tomas Benito Gonzalez1, Luis Renier Goncalves1, David Viñuela Baragaño2, Claudia Perez Martinez2, Jose Antonio Rodriguez Altonaga2
1Hospital Universitario de León, 2Universidad de León

Myocardial infarction by percutaneous embolization coil deployment in swine model

Daina Martínez-Falguera1, Edgar Fadeuilhe2, Oriol Rodriguez-Leor3, Albert Teis2, Julia Aranyo2, Raquel Adeliño4, Felipe Bisbal3, Carolina Gálvez-Montón*5
1ICREC Research Program, Health Science Research Institute Germans Trias i Pujol, Can Ruti Campus, Badalona, Spain; University of Barcelona, Barcelona, Spain., 2Heart Institute (iCor), Germans Trias i Pujol University Hospital, Badalona, Spain, 3Heart Institute (iCor), Germans Trias i Pujol University Hospital, Badalona, Spain; CIBERCV, Instituto de Salud Carlos III, Madrid, Spain, 4Department of Cardiology, Bellvitge University Hospital Hospitalet de Llobregat, 08001 Barcelona, Spain; ICREC Research Program, Health Science Research Institute Germans Trias i Pujol, Can Ruti Campus, Badalona, Spain, 5ICREC Research Program, Health Science Research Institute Germans Trias i Pujol, Can Ruti Campus, Badalona, Spain; CIBERCV, Instituto de Salud Carlos III, Madrid, Spain

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