Guest Editors
Xinrong Tao
Anhui University of Science and Technology
<p>Dr. Xinrong Tao earned her PhD in cell biology from the Second Military Medical University (SMMU) and completed her postdoctoral research in tumor cell biology and viral immunology at the University of Texas Medical Branch (UTMB) in 2016. She is currently a doctoral and postdoctoral supervisor at Anhui University of Science and Technology (AUST). Dr. Tao has directed one project funded by the National Natural Science Foundation of China and three projects supported by the Anhui Provincial Department of Education and the Department of Science and Technology. Her research focuses on the pathophysiology and treatment of coronavirus disease, silicosis, and nicotine-induced developmental and behavioral abnormalities in offspring. She has published over twenty papers on these topics in peer-reviewed scientific journals.</p>
Rui Shang
Anhui University of Science and Technology
<p>Professor Rui Shang earned his MD in comparative literature from Anhui University. He is a master’s supervisor at Anhui University of Science and Technology (AUST) and director of the Department of English for Graduate Students. He has led ten provincial-level research projects on college English teaching and has significantly contributed to the advancement of graduate English education. His work has had a notable impact on the field, and he has published numerous related papers and books.</p>
Deyong Ge
Anhui University of Science and Technology
<p>Dr. Deyong Ge earned his Doctor of Science from the University of Chinese Academy of Sciences. He is currently an associate professor and master’s supervisor in the School of Medicine at Anhui University of Science and Technology. He has led and contributed to four provincial- and ministerial-level research projects and has published extensively in SCI-indexed journals. His research primarily focuses on the molecular mechanisms underlying the onset and progression of dust-induced lung diseases, as well as the functions, catalytic activity, and molecular regulation of metabolic enzymes.</p>
Yanhua Jin
Yanbian University, Yanji Translational Medicine Research Center
<p>Dr. Yanhua Jin earned her PhD in systems biology from the College of Life Science and Biotechnology at Yonsei University, South Korea, in 2011. She is currently an associate professor and director of the Department of Cell Biology and Medical Genetics at the Medical School of Yanbian University. She also serves as GMP Laboratory Director at the Yanji Translational Medicine Research Center, a collaborative initiative of the People’s Government of Yanji Municipality, the Yanji National High-Tech Industrial Development Zone, and Yanbian University. In addition, she is head of the R&D Department at Jilin Xinchao Biotechnology Co., Ltd. Dr. Jin has led one National Natural Science Foundation of China project and three horizontal projects. Her research focuses on regenerative medicine, including stem cells, immune cells, and exosomes, as well as cell storage. She has published several papers indexed in SCI in these fields.</p>
Yingci Zhang
The First Affiliated Hospital of Anhui University of Technology
<p>Dr. Yinci Zhang’s research focuses on tumor mechanisms and prevention, as well as the pathogenic mechanisms and control of occupational hazard factors. She has led one Anhui Provincial Graduate Research Project and one Anhui University of Science and Technology Graduate Innovation Fund project. In addition, she has contributed to two NSFC General Program projects and one Major Natural Science Research Project for Anhui Provincial Universities (under her supervisor’s leadership). Her publication record includes seven SCI papers as first author (five in CAS Q1/Q2 journals and two with impact factors above 7), three SCI papers as second author, and co-authorship on more than 20 SCI publications.</p>
Bing Li
Anhui University of Science and Technology
<p>Dr. Bing Li has long been dedicated to researching respiratory immune impairment caused by mine dust. Using a pneumoconiosis mouse model, he has carried out behavioral experiments, histopathological analyses, cellular assays, and molecular biology studies. He is also skilled in applying single-cell transcriptome sequencing and spatial transcriptome sequencing technologies, and he has published over 10 related papers to date.</p>
Collection Overview
Understanding the efficacy and safety of stem cell-based therapies is critical for advancing regenerative medicine and treating debilitating diseases. Animal models remain indispensable, providing complex in vivo systems to rigorously evaluate stem cell behavior, therapeutic mechanisms, integration, differentiation, biodistribution, and potential adverse effects before human trials. Selecting and validating appropriate models is fundamental to generating reliable, translatable preclinical data.
This collection aims to collate cutting-edge research and critical reviews on the development, application, and validation of animal models specifically for stem cell therapy research. It will offer a dedicated platform to share best practices, tackle challenges (such as immunocompatibility and model relevance), showcase innovative model systems, and present key preclinical findings. By consolidating this knowledge, the collection will accelerate translational progress, enhance the predictive value of preclinical studies, foster methodological standardization, and ultimately help the research community design more effective and safer stem cell-based clinical trials.
Articles
A Silicosis Mouse Model Established by Repeated Inhalation of Crystalline Silica Dust
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Cited by 3
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2023
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Hangbing Cao*1,2,3,4, Bing Li*1,2,3,4, Haoming Chen1,3,4, Yehong Zhao1,4, Yuanjie Zou1,4, Yang Liu1,4, Min Mu1,2,3,4, Xinrong Tao1,2,3,4
1Key Laboratory of Industrial Dust Control and Occupational Health of the Ministry of Education, Anhui University of Science and Technology, 2Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Anhui University of Science and Technology, 3Anhui Province Engineering Laboratory of Occupational Health and Safety, 4School of Medicine, Department of Medical Frontier Experimental Center, Anhui University of Science and Technology
Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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2024
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Lei Xu*1,2, Manman Xu*3, Yinghai Xie4, Wei You2, Jianxin Wang2, Liwu Xu4, Qizhu Feng4, Jie Sun4, Jian Zhang4, Huaichen Yang4, Wang Qi4
1The First Affiliated Hospital of Anhui University of Science & Technology, 2Medical College of Anhui University of Science & Technology, 3Endocrinology Department, The First Affiliated Hospital of Anhui University of Science & Technology, 4Department of Hepatobiliary Surgery, The First Affiliated Hospital of Anhui University of Science & Technology
Using Nicotine in a Silica-Exposed Mouse Model to Promote Lung Epithelial-Mesenchymal Transition
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2023
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Haoming Chen*1,2,3,4, Bing Li*1,2,3,4, Hangbing Cao1,2,3,4, Yehong Zhao1,2,3,4, Yuanjie Zou1,2,3,4, Wenyang Wang1,2,3,4, Min Mu1,2,3,4, Xinrong Tao1,2,3,4
1Key Laboratory of Industrial Dust Control and Occupational Health of the Ministry of Education, Anhui University of Science and Technology, 2Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes, Anhui University of Science and Technology, 3Anhui Province Engineering Laboratory of Occupational Health and Safety, 4School of Medicine, Department of Medical Frontier Experimental Center, Anhui University of Science and Technology
Abstracts
The Molecular Mechanism of DMSO in Anti-Silicosis Fibrosis Mediated by the IL-6/STAT3-MMP12 Axis Based on Transcriptome Sequencing Analysis
Yukang Zhu1
1The First Hospital of Anhui University of Technology