Fluid Flow Regulation
Fluid Flow Regulation - Related Videos
01:27
Steady Flow of a Fluid Stream
0 Views •
2024
Consider a control volume, such as a pipe with solid boundaries, through which fluid flows and changes direction due to the impulse exerted by the resulting force from the pipe walls. In steady flow, the mass of fluid entering the control volume at a given time, t, with velocity v1, is equal to the mass leaving after infinitesimal time dt, with velocity v2. During this process, the momentum of the fluid within the control volume remains constant over the time interval dt. By applying the...
12:39
Computational Fluid Dynamics Simulations of Blood Flow in a Cerebral Aneurysm
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2023
Source: Joseph C. Muskat, Vitaliy L. Rayz, and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana The objective of this video is to describe recent advancements of computational fluid dynamic (CFD) simulations based on patient- or animal-specific vasculature. Here, subject-based vessel segmentations were created, and, using a combination of open-source and commercial tools, a high-resolution numerical solution was determined within a flow model.
03:03
Identification and Enumeration of Immune Cells in Bronchoalveolar Lavage Fluid by Flow Cytometry
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2025
This video demonstrates the use of flow cytometry to identify and count various immune cells in bronchoalveolar lavage fluid. Initially, single immune cells are identified using a viability dye, followed by differential staining of surface marker proteins, enabling the precise enumeration of each cell type.
08:11
Analysis of Gene Function and Visualization of Cilia-Generated Fluid Flow in Kupffer's Vesicle
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Cited by 19 •
2013
Cilia-generated fluid flow in Kupffer’s Vesicle (KV) controls left-right patterning of the zebrafish embryo. Here, we describe a technique to modulate gene function specifically in KV cells. In addition, we show how to deliver fluorescent beads into KV to visualize fluid flow.
07:41
Three-dimensional Cell Culture Model for Measuring the Effects of Interstitial Fluid Flow on Tumor Cell Invasion
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Cited by 13 •
2012
Interstitial fluid flow is elevated in solid tumors and can modulate tumor cell invasion. Here we describe a technique to apply interstitial fluid flow to cells embedded in a matrix and then measure its effects on cell invasion. This technique can be easily adapted to study other systems.
FAQs
A change in driving pressure can increase movement through a system, while greater resistance reduces it. Resistance may arise from valves, narrow channels, porous materials, or other geometric features. Adjusting these factors allows engineers to tune flow rate and distribution without necessarily changing the entire system, which is important when a device must maintain controlled operating conditions.
Sensors provide information about changing conditions, allowing a control system to adjust pumps, valves, or other flow-regulating elements. This feedback approach is useful when resistance, pressure, or biological demand changes during operation. Instead of relying only on a fixed setting, the system can respond dynamically and help preserve target flow conditions.
Changes in channel geometry alter resistance and influence how fluid is distributed through a device. They can therefore affect the shear stress experienced by cells or tissues, as well as the time fluid remains in a region. Designing geometry together with pressure and resistance controls helps bioengineers establish conditions that are more reproducible and biologically appropriate.
Residence time depends on how quickly fluid moves through a defined region and how flow is distributed among available pathways. Pumps, valves, channel dimensions, and porous materials provide ways to adjust that behavior. Controlling residence time helps manage exposure to nutrients or other fluid-borne conditions in systems such as microfluidic devices and bioreactors.
A practical design begins by identifying the required flow rate, pressure behavior, distribution, shear stress, or residence time. Engineers then select suitable pumps, valves, channels, porous materials, or geometry changes and incorporate sensors when conditions may vary. The resulting configuration can be adjusted to protect cells or tissues and improve experimental reproducibility.
Applications include microfluidic devices, organ-on-chip platforms, bioreactors, and artificial circulation systems. In these settings, controlled flow supports nutrient delivery, establishes defined shear stress, and manages residence time. The same principle also helps therapeutic devices respond to changing biological demands, linking engineering control with the maintenance of functional cellular or tissue environments.