Ventricular Function
Ventricular Function - Related Videos
09:22
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
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Cited by 22 •
2015
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) and Right Ventricular (RV) dysfunction were induced in piglets by progressive obstruction of the pulmonary arteries. Consequences were remarkably similar to those observed in CTEPH patients. This animal model would be a very useful tool for pathophysiology and therapeutic experiments on CTEPH and RV failure.
14:39
Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
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Cited by 44 •
2014
Current knowledge on the cellular basis of cardiac diseases mostly relies on studies on animal models. Here we describe and validate a novel method to obtain single viable cardiomyocytes from small surgical samples of human ventricular myocardium. Human ventricular myocytes can be used for electrophysiological studies and drug testing.
07:24
Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
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Cited by 34 •
2013
This article describes procedures for implanting a novel hydrogel in failing hearts and quantifying its effect on left ventricular wall stress and function. These procedures have been successfully applied in dogs and humans.
10:33
Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
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Cited by 34 •
2014
Right ventricle (RV) dysfunction is critical to the pathogenesis of cardiovascular disease, yet limited methodologies are available for its evaluation. Recent advances in ultrasound imaging provide a noninvasive and accurate option for longitudinal RV study. Herein, we detail a step-by-step echocardiographic method using a murine model of RV pressure overload.
09:40
Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
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Cited by 9 •
2019
Here, we provide a useful approach for studying the mechanism of right ventricular failure. A more convenient and efficient approach to pulmonary artery constriction is established using surgical instruments made inhouse. In addition, methods to evaluate the quality of this approach by echocardiography and catheterization are provided.
FAQs
These four factors influence stroke volume through different but connected mechanisms. Preload reflects ventricular filling, afterload represents the pressure the ventricle must overcome, contractility describes myocardial force generation, and compliance indicates how readily the ventricle accommodates blood during filling. Their combined effects help explain why changes in filling, pressure, contraction, or relaxation can alter cardiac output.
Systolic performance concerns the ventricle’s ability to generate pressure through contraction, whereas diastolic performance concerns relaxation and blood entry. Evaluating both phases provides a more complete picture than examining pumping alone. A clinical assessment that considers filling and contraction can better characterize altered ventricular performance and its potential effect on stroke volume and tissue perfusion.
Compliance affects how readily a ventricle receives blood during diastole. When compliance changes, the relationship between filling and ventricular performance may also change, influencing preload and ultimately stroke volume. Considering compliance alongside contractility, afterload, and preload helps clinicians interpret why cardiac output may change even when the primary problem is related to filling rather than myocardial contraction.
Ejection fraction provides a quantitative component of ventricular assessment by relating the amount of blood ejected to ventricular filling. It is interpreted with other findings, including wall motion and broader clinical measurements, rather than in isolation. This combined approach supports evaluation of cardiovascular performance and helps identify patterns associated with heart failure or cardiomyopathy.
Echocardiography contributes structural and functional information to the clinical evaluation. In particular, it can be used within an assessment that considers ejection fraction and regional wall motion, helping clinicians examine how effectively the ventricles perform. These findings support recognition of abnormal cardiovascular performance and can be followed over time when monitoring a patient’s condition.
No single measurement captures every aspect of ventricular performance. Echocardiography contributes information such as ejection fraction and wall motion, while electrocardiography, pressure measurements, and biomarkers add complementary clinical evidence. Combining these assessment methods gives clinicians a broader basis for identifying altered function, evaluating its significance, and monitoring changes in cardiovascular performance.
Clinicians assess ventricular function when investigating or monitoring conditions that can impair cardiovascular performance, including heart failure, cardiomyopathy, and valvular disease. The results help identify abnormal ventricular behavior, guide treatment decisions, and track changes over time. Because assessment can include imaging, electrical evaluation, pressure measurements, and biomarkers, the workup can be adapted to the clinical question.