Rodent Tail-cuff
Rodent Tail-cuff - Related Videos
08:54
Measuring Blood Pressure in Mice using Volume Pressure Recording, a Tail-cuff Method
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Cited by 175 •
2009
The CODA 8-Channel High Throughput Non-Invasive Blood Pressure system measures the blood pressure in up to 8 mice or rats simultaneously. This tail-cuff system uses Volume Pressure Recording (VPR) to measure the blood pressure by determining the tail blood volume.
10:17
The Tail Suspension Test
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Cited by 534 •
2012
The tail-suspension test is validated as an experimental procedure to assess antidepressant efficacy of drug treatments in mice. Mice are suspended by their tails for six minutes and escape-related behaviors are assessed. We describe procedures used in conducting the tail suspension test.
07:51
Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
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Cited by 30 •
2012
The constricting cuff presented in this article is designed to induce atherosclerosis in the murine common carotid artery. Due to the conical shape of its inner lumen the implanted cuff generates well-defined regions of low, high and oscillatory shear stress triggering the development of atherosclerotic lesions of different inflammatory phenotypes.
14:12
Rodent Identification II
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2015
Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN Animal records must be accurately maintained to ensure that data collection is correct. Records range from maintaining information on cage cards to having a detailed database with all of the relevant information on each animal. The primary component of recordkeeping is the individual identification of research animals. There are a variety of methods suitable for identifying mice and rats. This...
13:19
Mouse Model for Pancreas Transplantation Using a Modified Cuff Technique
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Cited by 6 •
2017
Among abdominal solid organ transplantation, pancreatic grafts are prone to develop severe ischemia reperfusion injury-associated graft damage, leading eventually to early graft loss. This protocol describes a model of murine pancreas transplantation using a non-suture cuff technique, ideally suited for analyzing these early, deleterious damages.
FAQs
The cuff first applies enough pressure to temporarily occlude blood flow in the tail. As cuff pressure changes, the sensor identifies when pulsatile flow returns, and that transition supports an estimate of arterial blood pressure. This pressure-flow relationship allows the system to obtain cardiovascular measurements without surgically accessing the circulation.
Photoplethysmography and volume-pressure recording provide alternative sensor approaches for detecting changes associated with returning pulsatile tail blood flow. Their measurements supply the signal used to relate cuff pressure to arterial pressure. Selecting and consistently applying the available sensor system matters because reliable detection is necessary for meaningful cardiovascular phenotyping and treatment-response measurements.
These conditions influence whether the tail produces a usable blood-flow signal during measurement. Careful restraint helps maintain a consistent setup, warming supports tail blood flow, and correct cuff placement positions the occlusion and sensor system appropriately. If these factors vary substantially between measurements, signal quality and the reliability of estimated blood-pressure values can decline.
Rodent Tail-cuff measurements reduce the need for surgical intervention because the cuff and sensor system remain outside the animal. This makes the approach useful when researchers need cardiovascular measurements while limiting invasive procedures. Its value in engineering and biomedical studies comes from combining external sensing with repeated assessment of blood-pressure-related responses.
A typical preparation includes carefully restraining the rodent, warming the tail, positioning the cuff and sensor system, and checking calibration before measurement. Researchers then monitor the pressure-related signal as the cuff changes tail blood flow. Repeating calibration and maintaining consistent setup conditions help improve signal quality and measurement reliability across sessions.
The method supports cardiovascular phenotyping, hypertension studies, and evaluation of vascular or drug-related responses in laboratory rodents. It is especially relevant when repeated blood-pressure assessment is needed without surgical access. In engineering research, the cuff, sensor, restraint, warming, and calibration steps also provide practical variables for optimizing a biomedical measurement system.