Objective Respiratory Measurements
Objective Respiratory Measurements - Related Videos
08:51
Measuring Respiratory Function in Mice Using Unrestrained Whole-body Plethysmography
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Cited by 70 •
2014
The assessment of respiratory physiology has traditionally relied upon techniques, which require restraint or sedation of the animal. Unrestrained whole-body plethysmography, however, provides precise, non-invasive, quantitative analysis of respiratory physiology in animal models. In addition, the technique allows repeated respiratory assessment of mice allowing for longitudinal studies.
09:24
Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
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Cited by 8 •
2017
This paper introduces a method for repeated measurements of ventilation and respiratory muscle activity in a freely behaving amyotrophic lateral sclerosis (ALS) mouse model throughout disease progression with whole-body plethysmography and electromyography via an implanted telemetry device.
14:38
Creating Objects and Object Categories for Studying Perception and Perceptual Learning
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Cited by 12 •
2012
We describe a novel methodology for creating naturalistic 3-D objects and object categories with precisely defined feature variations. We use simulations of the biological processes of morphogenesis and phylogenesis to create novel, naturalistic virtual 3-D objects and object categories that can then be rendered as visual images or haptic objects.
06:43
The Crossmodal Congruency Task as a Means to Obtain an Objective Behavioral Measure in the Rubber Hand Illusion Paradigm
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Cited by 22 •
2013
We demonstrate how an objective measure can be employed in the widely employed rubber hand illusion paradigm. This measure is obtained by modifying the well-established crossmodal congruency task. This task allows the investigation of multisensory processes which are critical for modulations of body representations as in the rubber hand illusion.
13:10
Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
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Cited by 130 •
2013
The present protocol provides a detailed step-by-step description of the procedures required to execute measurements of respiratory system mechanics as well as the assessment of airway responsiveness to inhaled methacholine in mice using the forced oscillation technique (flexiVent; SCIREQ Inc, Montreal, Qc, Canada).
FAQs
Spirometry provides two complementary types of evidence: airflow measurements and lung-volume measurements. Reduced or altered airflow can support recognition of airway obstruction, whereas abnormal lung volumes can indicate impaired ventilation. Examining these variables together gives clinicians more specific information than relying on symptoms alone and helps characterize the patient’s respiratory abnormality.
Pulse oximetry measures blood oxygen saturation, while capnography records exhaled carbon dioxide. These measurements address different aspects of respiratory status, so they provide complementary clinical information. Using the appropriate instrument helps clinicians assess inadequate oxygenation separately from problems reflected by exhaled carbon dioxide and supports more targeted evaluation of respiratory changes.
Respiratory rate provides a direct quantitative measure of breathing frequency. When considered with airflow, lung volumes, oxygen saturation, or exhaled carbon dioxide, it contributes another indicator of respiratory status. Repeated measurements can reveal changes over time, helping clinicians recognize deterioration or assess whether a treatment is producing a meaningful response.
Standardized measurement conditions and correct equipment use are central to reliable results. Consistency reduces the influence of avoidable differences between assessments, making measurements easier to compare. This is particularly important when clinicians evaluate severity, monitor respiratory status over time, or determine whether observed changes reflect a response to an intervention.
Clinicians select measurements according to the respiratory question being evaluated. Spirometry can provide airflow and lung-volume information, pulse oximetry can assess blood oxygen saturation, and capnography can record exhaled carbon dioxide. The resulting data support diagnosis, severity assessment, treatment decisions, and follow-up rather than replacing clinical evaluation altogether.
Repeated assessments create a quantitative basis for comparing respiratory status before and after an intervention. Changes in respiratory rate, spirometry findings, oxygen saturation, or exhaled carbon dioxide can indicate improvement, persistence, or worsening of a problem. Consistent conditions and equipment use make these comparisons more interpretable during ongoing clinical monitoring.