Chronic Exposure

Chronic exposure is repeated or continuous contact with a chemical, physical agent, or environmental condition over an extended period, often at low or moderate intensity. Unlike acute exposure, its effects may develop gradually as persistent contact alters biological processes, overwhelms protective responses, or causes damage that accumulates over time. Environmental health studies examine chronic exposure to pollutants, contaminants, radiation, noise, and other stressors by assessing exposure duration, concentration, routes of contact, and individual susceptibility. This framework supports environmental monitoring, risk assessment, disease prevention, and the development of regulations designed to reduce long-term harm to people, wildlife, and ecosystems.

Chronic Exposure - Related Videos

Research

JoVE EoE - Neuropathology

Induction and Evaluation of Depression in Mice Through Chronic Stress Exposure

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2025

Source: Yan, Z., et al. Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice. J. Vis. Exp. (2019).The video demonstrates the process of establishing a mouse model of chronic stress-induced depression and assessing depressive behaviors. The chronic application of various stressors triggers the release of corticosterone, leading to neuronal over-excitation and eventual neuronal death, which results in depression-like symptoms in the mice.

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

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Cited by 7 •

2017

This study describes the successful generation of a new chronic obstructive pulmonary disease (COPD) animal model by repeatedly exposing mice to high concentrations of ozone.

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

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Cited by 1 •

2025

The protocol describes a study of the systemic and local skin effects of Ultraviolet B exposure in mice.

Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation

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Cited by 3 •

2015

A protocol to evaluate changes in DNA damage levels and DNA repair capacity that may be induced by chronic in vivo low dose irradiation in mouse spleen lymphocytes, by measuring phosphorylated histone H2AX, a marker of DNA double-strand breaks, using flow cytometry is presented.

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

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Cited by 6 •

2023

Presented here is a protocol for the 2BC/CIE model of alcohol dependence in mice to study alcohol use disorder.

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