Interleukin-15
Interleukin-15 - Related Videos
03:33
Evaluating the Effects of Fecal Microbiota Transplantation in an Interleukin-10 Deficient Mouse
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2025
This video demonstrates a procedure of fecal microbiota transplantation in an interleukin-10 deficient mouse with colon inflammation. Colonized fecal microbes in the gut release secondary metabolites, eliciting anti-inflammatory cytokine release and reducing colon inflammation.
01:16
Other Nuclides: 31P, 19F, 15N NMR
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2024
Many organic, inorganic, and biological molecules contain spin-half nuclei such as nitrogen-15, fluorine-19, and phosphorus-31. As a result, NMR studies of these nuclei have found extensive applications in chemical and biological research. While fluorine-19 and phosphorous-31 have high natural abundances (100%) and positive gyromagnetic ratios, nitrogen-15 has a low natural abundance and a negative gyromagnetic ratio. However, nitrogen-15 is still preferred over nitrogen-14 (which has a high...
08:43
Microinjection of Interleukin-6 into the Bloodstream of TSC Zebrafish Larvae to Study Neuropsychiatric Disorder-Like Behaviors
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2026
To model how inflammatory signals influence neurodevelopment in genetically susceptible organisms, we present a protocol for microinjecting IL-6 into the duct of Cuvier (common cardinal vein) of zebrafish larvae, enabling controlled induction of inflammation and assessment of its developmental impact in the context of tuberous sclerosis complex (TSC).
05:41
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
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Cited by 6 •
2022
The interaction of genetic susceptibility, mucosal immunity, and intestinal microecological environment is involved in the pathogenesis of inflammatory bowel disease (IBD). In this study, we applied fecal microbiota transplantation to IL-10 deficient mice and investigated its impact on colonic inflammation and heart function.
08:44
Microplot Design and Plant and Soil Sample Preparation for 15Nitrogen Analysis
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Cited by 2 •
2020
A microplot design for 15N tracer research is described to accommodate multiple in-season plant and soil sampling events. Soil and plant sample collection and processing procedures, including grinding and weighing protocols, for 15N analysis are put forth.
FAQs
Trans-presentation makes IL-15 signaling dependent on a cellular interaction: IL-15 remains associated with IL-15 receptor alpha on one cell, while a neighboring NK cell or CD8+ T cell receives the signal through the IL-2/15 receptor complex and shared gamma-chain signaling. This arrangement focuses communication between adjacent immune cells rather than describing IL-15 simply as a freely acting soluble factor.
The receptor context connects IL-15 to several distinct immune outcomes. Engagement of the IL-2/15 receptor complex and shared gamma-chain signaling supports NK-cell maturation and cytotoxicity, while it promotes CD8+ T-cell proliferation. Examining both populations is therefore important because IL-15 influences innate-like cellular activity and adaptive lymphocyte expansion through related receptor machinery.
During infection, IL-15 connects cellular defense with longer-term immune protection. Its effects on NK cells support activation and cytotoxicity, while stimulation of CD8+ T cells contributes to proliferation and immunological memory. This combination explains why IL-15 is studied not only for host defense during infection but also for how immune responses are sustained beyond the initial challenge.
IL-15 research in antiviral and antitumor immunity examines how NK-cell cytotoxicity and CD8+ T-cell proliferation contribute to protection against infection or tumors. The cytokine is therefore relevant to studies of host defense as well as immune-based tumor control. Its trans-presentation mechanism also helps investigators interpret how neighboring immune-cell interactions may shape these responses.
In vaccine research, IL-15 is relevant because it connects immune-cell activation with the development or maintenance of immunological memory. Investigators can consider its relationship to NK-cell maturation, cytotoxicity, and CD8+ T-cell proliferation when examining vaccine-associated immune responses. The cytokine thus provides context for studying how vaccination may engage cellular defense and longer-term immune readiness.
These research areas examine how IL-15-associated NK-cell and CD8+ T-cell activity relates to different immune contexts. In cytokine-based immunotherapy, IL-15 provides a basis for studying deliberate immune activation. In inflammatory-disease research, the same biology helps frame questions about immune responses that may become improperly regulated, making receptor interactions and cellular targets important considerations.