Drug-eluting Beads Tace
Drug-eluting Beads Tace - Related Videos
09:49
Dual-phase Cone-beam Computed Tomography to See, Reach, and Treat Hepatocellular Carcinoma during Drug-eluting Beads Transarterial Chemo-embolization
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Cited by 22 •
2013
Dual-phase cone-beam computed tomography (DP-CBCT) is a useful intraprocedural imaging technique for transarterial chemo-embolization treatment with drug-eluting beads of hepatocellular carcinoma. DP-CBCT has been used to perform three major steps in oncologic interventional radiology: tumor localization (see), navigation and intraprocedural catheter guidance (reach), and intraprocedural evaluation of treatment success (treat).
06:18
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
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Cited by 5 •
2023
Here, we present a protocol to evaluate the antibacterial efficacy of an antibiotic-eluting polymer to simulate prophylactic clinical application by using a commercially available real-time ATP-based luminescent microbial viability assay. This method enables the monitoring of the longitudinal activity of drug-eluting materials and can be widely adapted to test anti-microbial drug delivery platforms.
08:26
Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis
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Cited by 13 •
2020
Laryngotracheal stenosis results from pathologic scar deposition that critically narrows the tracheal airway and lacks effective medical therapies. Using a PLLA-PCL (70% poly-L-lactide and 30% polycaprolactone) stent as a local drug delivery system, potential therapies aimed at decreasing scar proliferation in the trachea can be studied.
06:48
Antibody Labeling with Fluorescent Dyes Using Magnetic Protein A and Protein G Beads
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Cited by 3 •
2016
The on-bead method for labeling antibodies with small molecules enables labeling of a small amount of antibodies directly from cell media. This method is compatible with amine and thiol chemistry, and can handle multiple samples in parallel, manually or using automated platforms.
01:05
High-Performance Liquid Chromatography: Elution Process
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2024
In High-Performance Liquid Chromatography (HPLC), the elution process is critical to the separation of analytes and the quality of chromatographic results. Elution describes how compounds move through the column and separate based on their interactions with the mobile and stationary phases. This process determines the resolution, peak shape, and retention times in the chromatogram, which are essential for identifying and quantifying components in complex mixtures. Understanding the elution...
FAQs
The treatment combines sustained chemotherapy delivery with arterial embolization. After the microspheres lodge in tumor-feeding vessels, they gradually release the drug within the target region while reducing arterial flow. This coordinated action concentrates treatment where it is needed and creates a localized vascular effect rather than relying only on drug distribution throughout the body.
Gradual release keeps chemotherapy associated with the treated tumor region after catheter placement, rather than delivering the entire drug dose at once. This controlled-delivery feature is central to the method’s rationale: it supports localized exposure while the beads remain positioned in tumor-feeding arteries. The approach therefore links drug delivery with vascular targeting.
Systemic chemotherapy distributes medication through the body, whereas this technique places drug-loaded microspheres directly into arteries supplying the tumor. The localized route is intended to concentrate chemotherapy in the treated area and limit systemic exposure. Its distinctive feature is the combination of targeted arterial delivery, gradual release, and reduced blood flow.
Tumor-feeding arteries provide the access route and the target vascular bed for the procedure. A catheter is guided into these vessels so the microspheres can reach and lodge within the tumor’s arterial supply. Their final location determines where chemotherapy is released and where embolization reduces arterial flow, making vascular targeting essential to the treatment strategy.
The procedure begins with image-guided catheter navigation toward arteries supplying the tumor. Drug-loaded microspheres are then delivered through the catheter into those vessels, where they lodge and release chemotherapy gradually. Their placement restricts arterial flow while maintaining localized drug delivery. This workflow integrates catheter-based intervention, image guidance, controlled release, and embolization.
The primary clinical use is unresectable hepatocellular carcinoma, particularly when the tumor cannot be removed surgically. Selected liver metastases may also be treated. In these settings, the technique provides an image-guided interventional oncology option that targets tumor-feeding arteries and supports localized therapy when direct surgical removal is not feasible.