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Journal / Bioengineering / Design of a Biocompatible Drug-Eluting Tracheal…
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Bioengineering

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JoVE Journal Bioengineering
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Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis

Article DOI: 10.3791/60483-v • 08:26 min • January 21st, 2020
January 21st, 2020 •
1, 2, 2, 2, 2, 2, 2
1Department of General Surgery, University of California, San Francisco, 2Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine

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Summary
Automatic Translation

Laryngotracheal stenosis results from pathologic scar deposition that critically narrows the tracheal airway and lacks effective medical therapies. Using a PLLA-PCL (70% poly-L-lactide and 30% polycaprolactone) stent as a local drug delivery system, potential therapies aimed at decreasing scar proliferation in the trachea can be studied.

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Drug-eluting Tracheal Stent Mice Laryngotracheal Stenosis Small Animal Model Genetically Modified Animals Transoral Placement Drug Delivery Strategies Local Drug Delivery Translational Investigation Larger Animal Models Clinical Application Transoral Intubation Trachea Injury Airway Stent Placement Rapamycin Containing Polymer Solution 70-30 PLLA-PCL Dichloromethane Glycerol Murine Airway
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