Orthotopic Glioma Model
Orthotopic Glioma Model - Related Videos
09:43
Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
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Cited by 10 •
2014
Malignant gliomas constitute a heterogeneous group of highly infiltrative glial neoplasms with distinct clinical and molecular features. Primary orthotopic xenografts recapitulate the histopathological and molecular features of malignant glioma subtypes in preclinical animal models.
08:43
Orthotopic Mouse Model of Colorectal Cancer
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Cited by 109 •
2007
Two techniques can be used to establish this model: injection of a cancer cell suspension into the cecal wall or transplantation of a piece of subcutaneous tumor onto the cecum. This model is useful for studying the natural progression of colorectal cancer and testing new therapeutic agents against colorectal cancer.
07:44
Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
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2025
The development of orthotopic pediatric brain tumor models requires meticulous precision, using a stereotaxic device to implant cancer cells precisely. The methodology presented here outlines the steps involved in preparing brain tumor cells, performing intracranial injections, and implementing a post-operative monitoring system to assess brain tumor engraftment.
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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Cited by 10 •
2013
Generation of an orthotopic mouse model of anaplastic thyroid carcinoma is described here. This technique employs surgical placement of human anaplastic thyroid cancer cells into the thyroid of immunodeficient mice, thus creating a more clinically relevant setting to study disease progression as well as screen innovative therapeutic interventions.
09:07
An Orthotopic Model of Murine Bladder Cancer
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Cited by 24 •
2011
Bladder tumors are established in female mice in a minimally invasive fashion through catheterization, local cauterization, and subsequent adhesion of carcinoma cells to the burn sites.
FAQs
Tumor cells develop in contact with neural tissue, blood vessels, extracellular matrix, and immune components. These surrounding elements can influence how the glioma grows, interacts with host tissue, and responds to treatment. Preserving these relationships makes the model useful for studying tumor behavior that depends on the brain’s local biological environment.
Growth within the brain allows implanted glioma cells or tissue to form clinically relevant patterns of invasion. Researchers can therefore examine how tumors extend through surrounding neural tissue rather than evaluating growth in isolation. This is especially relevant when investigating progression, treatment response, and mechanisms that may contribute to therapeutic resistance.
The model supports analysis of interactions among glioma cells, neural tissue, blood vessels, extracellular matrix, and immune components. Studying these relationships helps connect tumor progression with the surrounding brain environment. It also provides a framework for examining how local biological conditions influence therapeutic response and the development of resistance.
Establishment requires implantation of glioma cells or tumor tissue into the corresponding anatomical site in the brain. The choice between cells and tissue represents the biological material introduced into the model, while placement at the relevant site enables subsequent growth within the brain environment. The source material does not specify additional equipment or procedural steps.
Researchers use this model to investigate glioma biology and tumor progression, then to evaluate potential treatments in a brain-based setting. Supported applications include studying surgery, radiotherapy, drug delivery, and emerging targeted or immune-based therapies. Its value lies in testing these approaches while tumor cells remain exposed to relevant neural and vascular surroundings.
An orthotopic glioma model can support evaluation of treatment response and mechanisms of therapeutic resistance. It is also used to examine interventions such as surgery, radiotherapy, drug delivery, and targeted or immune-based therapies. Results can help determine how candidate approaches perform in a tumor environment that includes neural tissue, blood vessels, extracellular matrix, and immune components.