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JoVE Journal
Medicine

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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
 

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Article DOI: 10.3791/50097
April 17th, 2013

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Summary April 17th, 2013

Generation of an orthotopic mouse model of anaplastic thyroid carcinoma is described here. This technique employs surgical placement of human anaplastic thyroid cancer cells into the thyroid of immunodeficient mice, thus creating a more clinically relevant setting to study disease progression as well as screen innovative therapeutic interventions.

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